ID J9HUS1_9SPIT Unreviewed; 1300 AA.
AC J9HUS1;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Antiviral helicase SKI2 {ECO:0000313|EMBL:EJY70097.1};
GN ORFNames=OXYTRI_09160 {ECO:0000313|EMBL:EJY70097.1};
OS Oxytricha trifallax.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC Stichotrichia; Sporadotrichida; Oxytrichidae; Oxytrichinae; Oxytricha.
OX NCBI_TaxID=1172189 {ECO:0000313|EMBL:EJY70097.1};
RN [1] {ECO:0000313|EMBL:EJY70097.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JRB310 {ECO:0000313|EMBL:EJY70097.1};
RX PubMed=23382650; DOI=10.1371/journal.pbio.1001473;
RA Swart E.C., Bracht J.R., Magrini V., Minx P., Chen X., Zhou Y.,
RA Khurana J.S., Goldman A.D., Nowacki M., Schotanus K., Jung S., Fulton R.S.,
RA Ly A., McGrath S., Haub K., Wiggins J.L., Storton D., Matese J.C.,
RA Parsons L., Chang W.J., Bowen M.S., Stover N.A., Jones T.A., Eddy S.R.,
RA Herrick G.A., Doak T.G., Wilson R.K., Mardis E.R., Landweber L.F.;
RT "The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic Genome
RT with 16,000 Tiny Chromosomes.";
RL PLoS Biol. 11:E1001473-E1001473(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJY70097.1}.
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DR EMBL; AMCR01017305; EJY70097.1; -; Genomic_DNA.
DR EnsemblProtists; EJY70097; EJY70097; OXYTRI_09160.
DR OrthoDB; 1352at2759; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF8; HELICASE SKI2W; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EJY70097.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 394..550
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 701..880
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 599..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 642..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1300 AA; 150372 MW; BB4C36223323EF4B CRC64;
MLKGNQNLQF DDIITSMEEV VTTVMQNEKP TNLLINETTK QLQVPLIYKV DSDGDRTIKA
HFLPPYQNND LFIADVLATY EQQIRPYEEP LEELNEVFAI NTEEMSVKYI QHILEESIDP
KEKSQFYKEE LEKIFKDIVT KDVEQASLRL SSDQLIGVGQ FNYITGEIDG FKVDVSQQVL
DTVYFDCQKI SDEEFEKLLN EVILPDDTKI DENPQIAASS LYDEHKMIHG FLESSKKYVT
NPRTDQEEEI NDLRNLDIDQ IMQRKKDQAK QLKDRQEKVQ DLNKISHQPI QDNLDLSLNQ
LIDGQQVEDE IDFIVQDSSQ LREALEKNQM QQQLPELNLV ASMSTNSNVI SQDAPLRKQW
YVIDEIDMKR FKEMIPNPAI EYDFELDDFQ KRALYRLEQN KCVFVAAHTS AGKTVVAEYA
IALAFKHMTK TIYTSPIKAL SNQKFRDFKE KFTDVGIKTG DVTLNGSASC VVMTTEILQM
MLYNESDFLK DVEWVIFDEV HYINDFERGT VWEEIIMKLP DHISFVMLSA TVPNYKEFAD
WVGRTKKKEI YVQMTEKRPV PLQHTLLYKD KFSVIKDELN NMNRDSLKKI LQEEKKDSFK
MRDEKNKGIK PKEEKQEEAK FEKKKEIDFK EKALKAKENQ IKKTAMKAQK SGGNGGGGQG
PNSQNKSNKK YEKFHKYLIS ISRDKLLPCV VFCFSRAACV EIPNQLQESL EFTTGQEKGE
IKKFLKSKLQ RLNESDRNLP QIQNIKSLLI RGIGYHHAGM LPIVKEIVEI LFADGYLKVI
FATTTFAIGL NMPARSVMFT QLFKFNGTES LILEASEYLQ MAGRAGRRGK DTTGTCILTL
DRAFGKVPDA EEFEEILTSK GTHLESKLKL SYQMALNVVK SEDVMINDLL KLSFFENEAE
KERQKATVKA QWLQVRIQRA EHLECVQVLS PKYFFEKVVV LQQLEKNQED FLCLLIRNNQ
YKPEIYNDEE EAKDQKKSSG VFGNFYYEYV RISPANVFRI YENFAEIGYK LTLHQERLPE
RPLKDIISVV SKFQVFKDWK LSPACNSYIK DKQNHMETLR TLPCFQCNLV IKHLGQIEAL
KKYESEMRQC KDLMGAGGQE KLDDFKAKVQ VLIHYKYIDY ELNMLFKGKV SELITNNKFL
LTELIFSGLL KELNNEEIIA LLSILDTQVG NSKADESDAF ISETFQKAVS FLNEEALKLI
EVEGRFGVQD AVSEISKYLN FQFYELLFEW ASQKPFVEIV KIAAVSEGDV VKVVQNVERL
LRQVKNASRV IGDAQLAERM DQCTLLIKRD IIFTPSLYLE
//
