ID J9HWP6_9SPIT Unreviewed; 497 AA.
AC J9HWP6;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=U4/U6.U5 tri-snRNP-associated protein 2 {ECO:0000313|EMBL:EJY70942.1};
GN ORFNames=OXYTRI_08190 {ECO:0000313|EMBL:EJY70942.1};
OS Oxytricha trifallax.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC Stichotrichia; Sporadotrichida; Oxytrichidae; Oxytrichinae; Oxytricha.
OX NCBI_TaxID=1172189 {ECO:0000313|EMBL:EJY70942.1};
RN [1] {ECO:0000313|EMBL:EJY70942.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JRB310 {ECO:0000313|EMBL:EJY70942.1};
RX PubMed=23382650; DOI=10.1371/journal.pbio.1001473;
RA Swart E.C., Bracht J.R., Magrini V., Minx P., Chen X., Zhou Y.,
RA Khurana J.S., Goldman A.D., Nowacki M., Schotanus K., Jung S., Fulton R.S.,
RA Ly A., McGrath S., Haub K., Wiggins J.L., Storton D., Matese J.C.,
RA Parsons L., Chang W.J., Bowen M.S., Stover N.A., Jones T.A., Eddy S.R.,
RA Herrick G.A., Doak T.G., Wilson R.K., Mardis E.R., Landweber L.F.;
RT "The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic Genome
RT with 16,000 Tiny Chromosomes.";
RL PLoS Biol. 11:E1001473-E1001473(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJY70942.1}.
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DR EMBL; AMCR01016491; EJY70942.1; -; Genomic_DNA.
DR AlphaFoldDB; J9HWP6; -.
DR EnsemblProtists; EJY70942; EJY70942; OXYTRI_08190.
DR OrthoDB; 719409at2759; -.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0000245; P:spliceosomal complex assembly; IEA:InterPro.
DR CDD; cd02669; Peptidase_C19M; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR033809; USP39.
DR InterPro; IPR028889; USP_dom.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001607; Znf_UBP.
DR PANTHER; PTHR21646:SF16; U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2; 1.
DR PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF02148; zf-UBP; 1.
DR SMART; SM00290; ZnF_UBP; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50235; USP_3; 1.
DR PROSITE; PS50271; ZF_UBP; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00502}.
FT DOMAIN 1..86
FT /note="UBP-type"
FT /evidence="ECO:0000259|PROSITE:PS50271"
FT DOMAIN 111..463
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
SQ SEQUENCE 497 AA; 57599 MW; 9FCBD81A79223C5B CRC64;
MLDFDLEKQC SVTLSNLNIY SCLTCGKYYQ GKGKTTQAYI HSLEQQHNVF INLQDSKVWC
LPDNYEVDDA ALNDIKYNLI PLYNQQLVDK LDSEPMIARA LDGTQFYPGS LGLNNLKQTD
FVNVIIQSLC RVKPLRDYCL FYNIHSENLS MADQKHLLVV KFAELIKKIW NPKNFKGHVS
PHELLQAISL ASQKRFKIGE QKDPIQLLSW LLNTFNEDLH SQQKQKKLKG LNMIEKTFQG
ELEISSLIPK GKQDANFLNK LAVSKTNMDT DVQYEMKNQK TKFFFLALDL PTIPLFKEQN
QLAAIPQIAL MQLLKKYDGK SFIEEPVTAI KKKFRILSLP KYLIIHVKRF NKNDYFTEKN
PTIVNFPIKN LDLSEYLWSP IAQQHQNDGS NTLNDAQPTK ETYKYDLIAN IIHEGKHDNG
QYRVQIHHKP TDEWYDIQDL HVNQIMPQQV VVSECYILVF ERQSTKPHEE EEVQNLIKEV
VNGLNSNNVQ SDTNGKM
//
