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Database: UniProt
Entry: J9HY10_9SPIT
LinkDB: J9HY10_9SPIT
Original site: J9HY10_9SPIT 
ID   J9HY10_9SPIT            Unreviewed;       878 AA.
AC   J9HY10;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   30-AUG-2017, entry version 16.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=OXYTRI_14463 {ECO:0000313|EMBL:EJY65383.1};
OS   Oxytricha trifallax.
OC   Eukaryota; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC   Stichotrichia; Sporadotrichida; Oxytrichidae; Oxytrichinae; Oxytricha.
OX   NCBI_TaxID=1172189 {ECO:0000313|EMBL:EJY65383.1, ECO:0000313|Proteomes:UP000006077};
RN   [1] {ECO:0000313|EMBL:EJY65383.1, ECO:0000313|Proteomes:UP000006077}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB310 {ECO:0000313|Proteomes:UP000006077};
RX   PubMed=23382650; DOI=10.1371/journal.pbio.1001473;
RA   Swart E.C., Bracht J.R., Magrini V., Minx P., Chen X., Zhou Y.,
RA   Khurana J.S., Goldman A.D., Nowacki M., Schotanus K., Jung S.,
RA   Fulton R.S., Ly A., McGrath S., Haub K., Wiggins J.L., Storton D.,
RA   Matese J.C., Parsons L., Chang W.J., Bowen M.S., Stover N.A.,
RA   Jones T.A., Eddy S.R., Herrick G.A., Doak T.G., Wilson R.K.,
RA   Mardis E.R., Landweber L.F.;
RT   "The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic
RT   Genome with 16,000 Tiny Chromosomes.";
RL   PLoS Biol. 11:E1001473-E1001473(2013).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EJY65383.1}.
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DR   EMBL; AMCR01021478; EJY65383.1; -; Genomic_DNA.
DR   EnsemblProtists; EJY65383; EJY65383; OXYTRI_14463.
DR   Proteomes; UP000006077; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006077};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006077};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    492    508       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    520    539       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    612    630       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    645    665       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    708    729       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      318    359       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   878 AA;  99632 MW;  2093171EB8568186 CRC64;
     MGIFRSDDMD LYQVTIPNDD AWYIMNEMGS MGSLHFVDLN KSEQTFHLPF AGQIKRAEDS
     LRRLAVLEQE CKKFRVKLVK PKSVESFLNS LKILQAERRK AENVLLDEVE TDVEQKEKFI
     SEQIKTLSEM QSNMNTLIEH KNVVAAASKI IMSAYAVGPD VRVDEESKQE IHIQMQEMEP
     SQDQPLTAGQ DGFEESKQPL IQKRETVTSK RETLSQAPQL LMPSSGSVAI SYLAGTINKD
     EIMRFKKMVY RATRGKALTY FQDMAASGLL DYAGKLDNRQ RSVYVVIFQE GQHIRDKLIK
     ICDSFLGKNF DIPPGCEQNE INRLIQHLED RIDDATKLIN QTRQRLRDYL REIQKVSQSQ
     IDANSASLIE IYRLFLQKEK VLYSSLNKLK KEDKLFLGFV WIPRADVGQV QKDIEDIKKK
     DENIELPTFT MVQEHGIRPP SLFRLNEFTW IFQEIVNTYG IPTYKEVNPS VFACVTFPFL
     FGIMFGDIGH GAFLFLIGAF LTLFAGPLRA KAPGLEPLLS LRYILLLMGF FAFYCGVIYN
     DFMAIPLWTF DSCYELKYYA LEEGSAHASD SVHHERMEAV PKEDCTYPIG VDPAWYMGKN
     ELAFLNSLKM KISVILGVMQ MSLGICMKAF NASYFKNKLD FFFEFVPQII LMIVLFGYMD
     LMIICKWMTD FKGRESMAPS VITTMIDMAL SGGAIAPGTQ GVVGSDGFQQ ALSIICLLIA
     LVCVPTMLFP KPLYIDKMNK LHAQQHHDAH NIPMQEQKAE TQGLLDGNQE QREQVLQQVE
     YNHPSKLDDW RSKKGKAITN YKLSDLQESE PAADAGHGEA FADIFIHQLI ETIEFVLGTI
     SNTASYLRLW ALSLAHGQLA AVSGLDTFCG LHSLSVCS
//
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