ID J9HYQ8_9SPIT Unreviewed; 1698 AA.
AC J9HYQ8;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=DNA polymerase theta subunit {ECO:0000313|EMBL:EJY70124.1};
GN ORFNames=OXYTRI_09133 {ECO:0000313|EMBL:EJY70124.1};
OS Oxytricha trifallax.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC Stichotrichia; Sporadotrichida; Oxytrichidae; Oxytrichinae; Oxytricha.
OX NCBI_TaxID=1172189 {ECO:0000313|EMBL:EJY70124.1};
RN [1] {ECO:0000313|EMBL:EJY70124.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JRB310 {ECO:0000313|EMBL:EJY70124.1};
RX PubMed=23382650; DOI=10.1371/journal.pbio.1001473;
RA Swart E.C., Bracht J.R., Magrini V., Minx P., Chen X., Zhou Y.,
RA Khurana J.S., Goldman A.D., Nowacki M., Schotanus K., Jung S., Fulton R.S.,
RA Ly A., McGrath S., Haub K., Wiggins J.L., Storton D., Matese J.C.,
RA Parsons L., Chang W.J., Bowen M.S., Stover N.A., Jones T.A., Eddy S.R.,
RA Herrick G.A., Doak T.G., Wilson R.K., Mardis E.R., Landweber L.F.;
RT "The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic Genome
RT with 16,000 Tiny Chromosomes.";
RL PLoS Biol. 11:E1001473-E1001473(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJY70124.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMCR01017285; EJY70124.1; -; Genomic_DNA.
DR EnsemblProtists; EJY70124; EJY70124; OXYTRI_09133.
DR OrthoDB; 208079at2759; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd18026; DEXHc_POLQ-like; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR046931; HTH_61.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR048960; POLQ-like_helical.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF6; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF20470; HTH_61; 1.
DR Pfam; PF21099; POLQ_helical; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 434..608
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 665..824
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 199..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1339..1397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1453..1488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1531..1567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1614..1683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1345..1378
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1379..1395
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1628..1652
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1653..1675
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1698 AA; 194501 MW; 53B28D5269D04B19 CRC64;
MNNKQSANQK SSTGPDKFPK VFVNDLDSDI DEELDNLILQ TFLNDDKNQQ SAKKANSNKT
DQKVAQNIDQ QSKLIGSSQY NSCKLVPQND SNQSHSFQQQ QQLQQTSQSN ANQQNLVESE
GQNSRLLHPE IYNTQLLRVN NGNIQNKNQH QQTHSSVQHQ QVFDENSNLP FYHNSIQKRK
LNNDLQQNNQ INSVIQVQNH NQQPSQSRDQ IELQQQKKSS VHQKQSKVVS GFQFKSTERK
NKTGVQRVFI NEPDEEEKQQ NYVPGLYSNY QQLYQTQKPG FSAIANNAVQ SDLSNHNLID
NKKSRVNKAL KLLREMKTKP RYKDKYGNNV KQHFGIYKYF INTQTQEKEK FYISHECQKI
PASQAMKTQQ KEMDILAQHK YHYYESIQKT GRVVKDKNRL EYWGLPSGIC DQFYKHTKIQ
KLFDWQSECL SQSKEVLDGK KNLIYFAPTS GGKSVVAELL MLRQILGYKK RAVYVLPFVS
IVTEKQQYLT KLLENVNVKI IGLHSQSENV WSPGVDIAIC TIEKANSLLN RIIEERAYFD
VGFFIIDEFH LILDEGRGYQ LESLIAKLRT VETIMNREKS FQIVGMSATL SGLDYLKQWF
GGNCELYECQ FRPVPLSEYL QIGSKLFNKE MKMIMDLSHL PKFQMIDSNG RSQTLAADND
YLPLVLSSYL RKKKAVLIFC PSKVQCEQVA KKLAAIMPTQ YPEYESKQSL HYEDIETEIK
EIGYRTGALL VLAATSTLST GINLPAKAVF FKGPYIAQMP MDAAKYKQMS GRAGRTGFDS
KGDSIMMCTN NDREYVLDLM KPFYCELKSA LTGQRLMRSL LEIIASNVVT SFKHIRIFIQ
STLKYTLCQK MRCNSCTQTY FQNEILFGVI QISDEAQLQK VQNQYNLYLE TFRLEQFKDE
IQDDDCKNCM LEFSKQVVAY LSKFKFLTFN PAEGTILPTQ LGKAAFASSI PPEHGQKIFE
DLAQARGNLV LETDLHLLYL ITPHFKQIRE PNWDAFIRKF SKLSKGEKNV AEFYGLDMEY
LYKATVYPPK LPVCLQDPSN SNGSSSMAQS KGLNALSLKS KMEKQATLTQ STMNTSSVHS
KDSSALDISS IQTPSMTQMD QLIQLQQLTA EEQKLVRYCK FYMAMIMNEI LKETPQNEIC
NIFNIKRGDI QTIQALAVNY SGMLSAFCER LFWSDYSVLL MRINEKINWC VKEELLDLMQ
CSSLRPERAR ALFTAGYETI EDIAKNGEIE SMVKIFDKND GFMSHRKSNE GDLKMRYDYY
YTLAHKVFCE AKMIMVKRKV DPDRTMMSYM QEQQQFVDVD QRYVLDSDYS SSEGSVLEGD
DEQEIEELAK LLEENGEDLA DLDSDSDDNT NKQQEKDVIN NNNSKKKKSI QMNKIDSDSD
DIDLDDFADD SDDDNNEQDI RLRGLQANQS NRNQHDMIND VHIQNTVNQQ LQLSQQSNND
IYDEDSSSFD LIITHSSDTS PNKKEQQPKN HSQNPNTNDI HSKNNNSKND IDLLLNQSIS
ISSDNSASVN HQQVSINAQA QQNNNSLKQI FDYNCNSSNN NSNDRNSNNN SKLVSINSIS
DKNNNPPQLQ IQSKIQVKSD PAVVRYSDVS SGNLHLSDID LFSALPDLDA DNNIKQQDTG
NIQHAENELD DDDLDDYELD QLCRDDEDDS GCDDVIQGKS SRKGSKKKQS SGDQFHDEED
DDDQLLDEMC QLLEDNSQ
//
