ID J9I5B4_9SPIT Unreviewed; 777 AA.
AC J9I5B4;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Villin {ECO:0000313|EMBL:EJY65755.1};
GN ORFNames=OXYTRI_14087 {ECO:0000313|EMBL:EJY65755.1};
OS Oxytricha trifallax.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC Stichotrichia; Sporadotrichida; Oxytrichidae; Oxytrichinae; Oxytricha.
OX NCBI_TaxID=1172189 {ECO:0000313|EMBL:EJY65755.1};
RN [1] {ECO:0000313|EMBL:EJY65755.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JRB310 {ECO:0000313|EMBL:EJY65755.1};
RX PubMed=23382650; DOI=10.1371/journal.pbio.1001473;
RA Swart E.C., Bracht J.R., Magrini V., Minx P., Chen X., Zhou Y.,
RA Khurana J.S., Goldman A.D., Nowacki M., Schotanus K., Jung S., Fulton R.S.,
RA Ly A., McGrath S., Haub K., Wiggins J.L., Storton D., Matese J.C.,
RA Parsons L., Chang W.J., Bowen M.S., Stover N.A., Jones T.A., Eddy S.R.,
RA Herrick G.A., Doak T.G., Wilson R.K., Mardis E.R., Landweber L.F.;
RT "The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic Genome
RT with 16,000 Tiny Chromosomes.";
RL PLoS Biol. 11:E1001473-E1001473(2013).
CC -!- SIMILARITY: Belongs to the villin/gelsolin family.
CC {ECO:0000256|ARBA:ARBA00008418}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJY65755.1}.
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DR EMBL; AMCR01021209; EJY65755.1; -; Genomic_DNA.
DR AlphaFoldDB; J9I5B4; -.
DR EnsemblProtists; EJY65755; EJY65755; OXYTRI_14087.
DR OrthoDB; 25995at2759; -.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR CDD; cd11292; gelsolin_S3_like; 1.
DR CDD; cd11291; gelsolin_S6_like; 1.
DR Gene3D; 3.40.20.10; Severin; 6.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR007122; Villin/Gelsolin.
DR PANTHER; PTHR11977:SF85; HP DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR11977; VILLIN; 1.
DR Pfam; PF00626; Gelsolin; 4.
DR PRINTS; PR00597; GELSOLIN.
DR SMART; SM00262; GEL; 6.
DR SUPFAM; SSF55753; Actin depolymerizing proteins; 6.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 45..120
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT DOMAIN 166..218
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT DOMAIN 280..350
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT DOMAIN 641..714
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
SQ SEQUENCE 777 AA; 88935 MW; 799C1F6903F89A74 CRC64;
MESHGFLERE ELDIQIKELQ AKAEAFFAVA GKEDIEVYRI EKFEPVRQDP EFLGKFYDGD
SYVILKRTEK DYDIHYWHGK HASGDEQATA AAFTVQLSEN LQLPSRHHLE LMMEESPLFL
SYFKSGIFYL EGGVESGFKH VEPKTYEKKL YIVKGKRYPR VWTLGASASN LNEGDVFILD
LGMKLFVWPG RECNVNEKMK GIEISFNIKK ERGAHPVVFY PRDDSSCEDE FWAELGGKPD
QINPAIPDEG VEGGSAGGEQ SYSFFKISNE SGKLELTEIT ERPLRKDHLD TNDTFLLELP
DTIYVWIGRK SNLEEKKNGM LTAKNFIEQK GKPKNTRISR IPEHAEDTHF KSFFNGFYPC
LKQDFGVAKG FDATTANLDI EKMANQQKQA AKQLFDMLQD YQMQVYVVEN DKPVALSESE
WGHFFADDIY IIDLKGKGHR YVLMWMGPKL EAEQHTATST YMDIVTNYEN SNLITRTRVR
RGHEEESLLS LFPNGFITHT GKRVPIQEKF AKIRNNGTML RVQAPYGDAA RAIEQIENKC
ANLNSGDAYI IIAAGGQQAY LWLGEGANDH EKSLGQKILD SYFSDIGEQK VYQEGQEADD
FWTAVGGQTE YSRSKDTGMA AGFEPRLFHC SNAHGYFYVQ EIYNFSQDDM LNDDIMLLDA
YNTIYVWIGN KSNEFEKRGA FKSAQKYIES VRDERDKDQV QIVEIQAGKE APSFTVLFPE
WRQDKAQKWL DADPVKQMQG KLLKGLTVKV EEQKVEASKF NDPKTHKIPY EQLKGII
//
