ID   J9ID48_9SPIT            Unreviewed;       737 AA.
AC   J9ID48;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=TKL family protein kinase {ECO:0000313|EMBL:EJY72113.1};
GN   ORFNames=OXYTRI_06890 {ECO:0000313|EMBL:EJY72113.1};
OS   Oxytricha trifallax.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC   Stichotrichia; Sporadotrichida; Oxytrichidae; Oxytrichinae; Oxytricha.
OX   NCBI_TaxID=1172189 {ECO:0000313|EMBL:EJY72113.1};
RN   [1] {ECO:0000313|EMBL:EJY72113.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JRB310 {ECO:0000313|EMBL:EJY72113.1};
RX   PubMed=23382650; DOI=10.1371/journal.pbio.1001473;
RA   Swart E.C., Bracht J.R., Magrini V., Minx P., Chen X., Zhou Y.,
RA   Khurana J.S., Goldman A.D., Nowacki M., Schotanus K., Jung S., Fulton R.S.,
RA   Ly A., McGrath S., Haub K., Wiggins J.L., Storton D., Matese J.C.,
RA   Parsons L., Chang W.J., Bowen M.S., Stover N.A., Jones T.A., Eddy S.R.,
RA   Herrick G.A., Doak T.G., Wilson R.K., Mardis E.R., Landweber L.F.;
RT   "The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic Genome
RT   with 16,000 Tiny Chromosomes.";
RL   PLoS Biol. 11:E1001473-E1001473(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJY72113.1}.
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DR   EMBL; AMCR01015412; EJY72113.1; -; Genomic_DNA.
DR   AlphaFoldDB; J9ID48; -.
DR   EnsemblProtists; EJY72113; EJY72113; OXYTRI_06890.
DR   OrthoDB; 181075at2759; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   PANTHER; PTHR23257; SERINE-THREONINE PROTEIN KINASE; 1.
DR   PANTHER; PTHR23257:SF779; SERINE_THREONINE-PROTEIN KINASE WNK4; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:EJY72113.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Transferase {ECO:0000313|EMBL:EJY72113.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        34..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        78..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        107..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        191..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          421..731
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          284..305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   737 AA;  85331 MW;  058D7B1DB9B2DED5 CRC64;
     MYRLGIDEQK FVGIRGAAAA SSQVDQIDLI PKPLFLFIIM PDFLFIIAFL LLFWQLLYLY
     NQGHANLFKV MCQGRGKILI LITITILSTL QSTMLLLYLF GAVSAKAFSI ECTILNFVAA
     TFVWIILLIY ALMFSGSPFR SNAYKLKMRK LTLAIVIWCA CRYFRGITGA FETRCYRFVM
     KSMTSEKNDS LALPILSILV FVIQEIAPLL YILDWSFMEI FVICGEQNAI RKFMGANYVY
     DGMNGYEYQE QMSLNFNHNH NALQESYRNS PALKNQLLSR NHYSISSNDQ GSGTGGIGSK
     NDSLSSLTNT NSRIKQLSGF KRYQLQLDGM VSRVKRQINL DINNQNPSNI EDFSAENRDC
     EINNHGSINL IQNDNMSSAG IEMMNQPSMN YNQQFINADS QDLIDLQQIF SIIIERKDFQ
     IEKLFDQKNR GLGKLYEARL YNKEVLCREI QFKRIKEYVV EDFIKEMICQ QNTGLREVLP
     ILGVNFDPKQ MALYVLMPRE QPLYKFIHQQ ENNRKIQPDL KKHIAIKIAY AMMKIQQKQK
     DPRIDIDQNY YSHKHLSSFN IMLNGKEESF LQSLNVLISD MDSELLKKYA KLFMNYQNLN
     AWSPPELFLQ DPYFKSTNTS MQSAQDQIQL TPQQTPSTGQ NQQLQLSPIL IQNDPRSIDV
     YSFGVILWEL ETQLVPFEGM EISEVKNLVV DQSLRPQILQ TTDQNLAYLI RCCWQKKADK
     RPTFEFIHNF LDKVQFS
//