ID   J9J8W1_9SPIT            Unreviewed;       875 AA.
AC   J9J8W1;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   08-NOV-2023, entry version 33.
DE   RecName: Full=rRNA methyltransferase 1, mitochondrial {ECO:0000256|ARBA:ARBA00034881};
GN   ORFNames=OXYTRI_18340 {ECO:0000313|EMBL:EJY83925.1};
OS   Oxytricha trifallax.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC   Stichotrichia; Sporadotrichida; Oxytrichidae; Oxytrichinae; Oxytricha.
OX   NCBI_TaxID=1172189 {ECO:0000313|EMBL:EJY83925.1};
RN   [1] {ECO:0000313|EMBL:EJY83925.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JRB310 {ECO:0000313|EMBL:EJY83925.1};
RX   PubMed=23382650; DOI=10.1371/journal.pbio.1001473;
RA   Swart E.C., Bracht J.R., Magrini V., Minx P., Chen X., Zhou Y.,
RA   Khurana J.S., Goldman A.D., Nowacki M., Schotanus K., Jung S., Fulton R.S.,
RA   Ly A., McGrath S., Haub K., Wiggins J.L., Storton D., Matese J.C.,
RA   Parsons L., Chang W.J., Bowen M.S., Stover N.A., Jones T.A., Eddy S.R.,
RA   Herrick G.A., Doak T.G., Wilson R.K., Mardis E.R., Landweber L.F.;
RT   "The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic Genome
RT   with 16,000 Tiny Chromosomes.";
RL   PLoS Biol. 11:E1001473-E1001473(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJY83925.1}.
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DR   EMBL; AMCR01004522; EJY83925.1; -; Genomic_DNA.
DR   AlphaFoldDB; J9J8W1; -.
DR   EnsemblProtists; EJY83925; EJY83925; OXYTRI_18340.
DR   OrthoDB; 5404245at2759; -.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR   GO; GO:0031167; P:rRNA methylation; IEA:InterPro.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.40.1280.10; -; 1.
DR   InterPro; IPR029028; Alpha/beta_knot_MTases.
DR   InterPro; IPR047182; MRM1.
DR   InterPro; IPR029064; Ribosomal_eL30-like_sf.
DR   InterPro; IPR001537; SpoU_MeTrfase.
DR   InterPro; IPR013123; SpoU_subst-bd.
DR   InterPro; IPR029026; tRNA_m1G_MTases_N.
DR   PANTHER; PTHR46103; RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR46103:SF1; RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL; 1.
DR   Pfam; PF00588; SpoU_methylase; 1.
DR   Pfam; PF08032; SpoU_sub_bind; 1.
DR   SMART; SM00967; SpoU_sub_bind; 1.
DR   SUPFAM; SSF75217; alpha/beta knot; 2.
DR   SUPFAM; SSF55315; L30e-like; 1.
PE   4: Predicted;
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT   DOMAIN          530..613
FT                   /note="RNA 2-O ribose methyltransferase substrate binding"
FT                   /evidence="ECO:0000259|SMART:SM00967"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          462..527
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          721..774
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        462..523
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        721..756
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   875 AA;  99565 MW;  B7C68371351F3181 CRC64;
     MSKSQAKLGS KKLPSSTEAA NHSFWQQRVS QEDQVPLQDC QTWSKPDDIK SSPRDGQLMI
     NKQKALQNLE DRINHSPRSR NNIMKEYYSN QDMVNSMRRL KGVESTYQSS MNLTSLQEKA
     PSPTYQLTTD NPPYGQYPKM FTSYQMQNQS PQPPNTLPIS NRSYANILKL TKKCYMGEDQ
     MPWIKTKIDL SFPEIKQVHL DGTKANPKMD QIMTLAYMRR DSDLKINKSN IKIQNKTINN
     NEEAQQYFQN VQSAVYRKQE HDSSQISLFG DKTQRENMSM RFQGIAQGLM NNKSQNQSRS
     QSVMNGGRKL QNHTQSLLMN QYQNNQNKLV DLPKVDLFNQ SAIEIKIDDQ DLLNGSSNRV
     NQDSAKNLNQ LQNAYQDNSQ LSNAQSQTKT PTMSNFLLKK RNSEAITSNI KLKPSKNRQY
     MVPDLSDQFN MMESLRKAKE LIQTRKDKNM NIQRKILANN SNITINGNNG YGNNRGSQGQ
     NQGQKQQYNN QSNYQQQRQQ QSPNSSSTSS SNFSASQSSG NPLKKPKPEY IYGINPVMAC
     LSAQRRQIQK LYLSITEKGG ENRKSHPKIE QIAKMASSQG IKLKYLHKVK LSGFTMSKPH
     QNVVIKASKL EYIKIRKDSD IEALKEPKKG QFYLFLDQIT DPQNFGSILR TAMFIGVDGI
     IVNQNNACGL TPTVSKVSSG ALEFIPLYST KFVKNFMQDA QKGLQNFKII STDIESLDSL
     DEKNQEKEVE VSVNSDSDDE NDGASSKGKG QKKDKSKLSF QQPSQAHNED GDNHYHEKYV
     EEDVDENMPF KTNKVLSIEE LRLNKDENII LVLGSEGEGV SKTINKLADY RVMIPPQLSP
     EMIGKYPFNM VDSLNVGVSA GLLIYHIRYL MRMKI
//