ID J9JHM5_CANLF Unreviewed; 370 AA.
AC J9JHM5;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=TNF superfamily member 13b {ECO:0000313|Ensembl:ENSCAFP00845039160.1};
DE SubName: Full=Tumor necrosis factor ligand 7A {ECO:0000313|EMBL:CTQ86242.1};
GN Name=TNFSF13B {ECO:0000313|Ensembl:ENSCAFP00845039160.1};
GN Synonyms=TNLG7A {ECO:0000313|EMBL:CTQ86242.1};
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00845039160.1, ECO:0000313|Proteomes:UP000805418};
RN [1] {ECO:0000313|EMBL:CTQ86242.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26646413; DOI=10.1007/s00251-015-0887-5;
RA Premzl M.;
RT "Comparative genomic analysis of eutherian tumor necrosis factor ligand
RT genes.";
RL Immunogenetics 68:125-132(2016).
RN [2] {ECO:0000313|EMBL:CTQ86242.1}
RP NUCLEOTIDE SEQUENCE.
RX DOI=10.1016/j.genrep.2019.100414;
RA Premzl M.;
RT "Eutherian third-party data gene collections.";
RL Gene Rep 16:100414-100414(2019).
RN [3] {ECO:0000313|Ensembl:ENSCAFP00845039160.1}
RP IDENTIFICATION.
RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00845039160.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LN874477; CTQ86242.1; -; mRNA.
DR STRING; 9615.ENSCAFP00000035956; -.
DR PaxDb; 9615-ENSCAFP00000035956; -.
DR Ensembl; ENSCAFT00845049936.1; ENSCAFP00845039160.1; ENSCAFG00845028286.1.
DR VEuPathDB; HostDB:ENSCAFG00845028286; -.
DR eggNOG; ENOG502RX35; Eukaryota.
DR GeneTree; ENSGT00940000157536; -.
DR HOGENOM; CLU_063693_0_0_1; -.
DR OMA; HGGQTEN; -.
DR Reactome; R-CFA-5668541; TNFR2 non-canonical NF-kB pathway.
DR Reactome; R-CFA-5669034; TNFs bind their physiological receptors.
DR Reactome; R-CFA-5676594; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.
DR Proteomes; UP000805418; Chromosome 22.
DR Bgee; ENSCAFG00000031735; Expressed in cartilage tissue and 45 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0048018; F:receptor ligand activity; IBA:GO_Central.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0030890; P:positive regulation of B cell proliferation; IBA:GO_Central.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15151; PROTEIN EIGER; 1.
DR PANTHER; PTHR15151:SF2; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13B; 1.
DR Pfam; PF00229; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000805418}.
FT DOMAIN 233..369
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 370 AA; 39971 MW; B7C438772432342F CRC64;
MIGQSNRRAS ARKTYHTGGA PRCGQADGGK LRRALLRATT GPGHVVRVGH EQAQLTGNDP
VPALTYSKGP NLQSCGSAMD GCTEGQQSRL SPCLERGEEM KLKECVSILP LKESPSVPCS
KDGTLLAVTL LLALTACCLS VVSFHRAAAL QAELGSLRAE LREQHAEPER LPGPPQARAR
APRAAMRETP AVTSALNGIL APSAAGEGNS SQSSRNKRAI QGPEETVTQD CLQLIADSDT
PTIRKGAYTF VPWLLSFKRG RALEEKENKI LVKEAGYFFI YSQVLYTDNT FAMGHLIQRK
KVHVFGDELS LVTLFRCIQN MPETLPNNSC YSAGIAKLEE GDELQLAIPR EDAKISRDGD
GTFFGALKLL
//
