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Database: UniProt
Entry: J9NWW6_CANLF
LinkDB: J9NWW6_CANLF
Original site: J9NWW6_CANLF 
ID   J9NWW6_CANLF            Unreviewed;       908 AA.
AC   J9NWW6;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   30-AUG-2017, entry version 26.
DE   SubName: Full=Transient receptor potential cation channel subfamily M member 5 {ECO:0000313|Ensembl:ENSCAFP00000037777};
GN   Name=TRPM5 {ECO:0000313|Ensembl:ENSCAFP00000037777};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000037777, ECO:0000313|Proteomes:UP000002254};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00000037777, ECO:0000313|Proteomes:UP000002254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000037777,
RC   ECO:0000313|Proteomes:UP000002254};
RX   PubMed=16341006; DOI=10.1038/nature04338;
RG   Broad Sequencing Platform;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA   Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA   Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA   Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA   Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA   Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA   Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA   Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA   Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA   Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA   Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA   Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA   Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA   Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA   Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA   Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA   Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA   Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA   Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA   Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA   Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA   Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA   Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA   Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA   Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA   Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA   Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA   Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA   Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA   Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA   Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA   Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA   Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA   Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA   Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2] {ECO:0000313|Ensembl:ENSCAFP00000037777}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000037777};
RG   Ensembl;
RL   Submitted (SEP-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00788929}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCAFP00000037777}.
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DR   EMBL; AAEX03011554; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PaxDb; J9NWW6; -.
DR   Ensembl; ENSCAFT00000048371; ENSCAFP00000037777; ENSCAFG00000010197.
DR   eggNOG; KOG3614; Eukaryota.
DR   eggNOG; ENOG410XR5B; LUCA.
DR   GeneTree; ENSGT00760000119127; -.
DR   Reactome; R-CFA-3295583; TRP channels.
DR   Proteomes; UP000002254; Chromosome 18.
DR   Bgee; ENSCAFG00000010197; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005227; F:calcium activated cation channel activity; IEA:InterPro.
DR   GO; GO:0050909; P:sensory perception of taste; IEA:InterPro.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR029577; TRPM5.
DR   PANTHER; PTHR13800:SF18; PTHR13800:SF18; 1.
DR   Pfam; PF00520; Ion_trans; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002254};
KW   Ion channel {ECO:0000256|SAAS:SAAS00816195};
KW   Ion transport {ECO:0000256|SAAS:SAAS00816776};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002254};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00816535}.
FT   TRANSMEM    473    498       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    557    578       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    621    642       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    697    717       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      489    733       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   908 AA;  104178 MW;  7FC8948A66B703E2 CRC64;
     MNQPHLLVPQ VAEKQFKEKF PGEHFCWEDI VHWTELLQNI TAHPHLLTVH DFEQEGSEEL
     DTVILKALVK ACKSHSQEAQ DYLDELKLAV AWDRVDIAKS EIFNGDVEWK SCDLEEVMMD
     ALVSNKPEFV RLFVDNGADV GDFLTYGRLQ QLYRAAPPKS LLFDLLQRKH EEGRLTLAGL
     GTPQAREPPV GLPAFSLHEV SRLLKDFLHD ACRGLYQEVS VHWRGGPQLG HQETDGPVLQ
     ERGPARRPEG RKWPLDLSRR SENPWRDLFL WAVLQNRHEM ATYFWAMGQE GVAAALAACK
     ILREMSHLET GAEVTRTVSE AKYEQLALGL FSECYSNSED RAFALLVRRN RCWSRTTCLH
     LATEADTKAF FAHDGVQAFL TRIWWGDMAS GTPILRLLCA FLCPALIYTN LITFSEETPP
     RTGPRDLQEL DSLDSEKSLL YGPGSRPEDL AEAPGAKSDQ GPRAAFLLTR WRMFWGAPVT
     VFLGNVVMYF AFLFLFTYVL LVDFRPPPQG PSGPEVTLYF WVFTLVLEEI RQGFFTNEDT
     HLVKKFTLYV EDNWNKCDMV AIFLFIVGVT CRMVPSVFEA GRTVLAVDFM VFTLRLIHIF
     AIHKQLGPKI IIVERMMKDV FFFLFFLSVW LVAYGVTTQA LLHPHDGRLE WVFRRVLYRP
     YLQIFGQIPL DEIDESRVNC SLHPRLHEGS PSCPNLYANW LVILLLVTFL LVTNVLLMNL
     LIAMFSYTFQ VVQGNADMFW KFQRYHLIVE YHERPALAPP FILLSHLSLV IKRVFQKGAE
     QKRVHLERDL PEPLDQKMVT WEAVQKENYL SKLEKQRKDS KEEVLRKTAH RVDSVAQYLG
     GLREQEKRIK RLESQINYCT VLLSSMAPSS TSWNSQNFKG GHQQASADHR GGADSRKHPE
     AGRPLSDT
//
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