GenomeNet

Database: UniProt
Entry: J9NX93_CANLF
LinkDB: J9NX93_CANLF
Original site: J9NX93_CANLF 
ID   J9NX93_CANLF            Unreviewed;      1879 AA.
AC   J9NX93;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   30-AUG-2017, entry version 37.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN5A {ECO:0000313|Ensembl:ENSCAFP00000037905};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000037905, ECO:0000313|Proteomes:UP000002254};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00000037905, ECO:0000313|Proteomes:UP000002254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000037905,
RC   ECO:0000313|Proteomes:UP000002254};
RX   PubMed=16341006; DOI=10.1038/nature04338;
RG   Broad Sequencing Platform;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA   Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA   Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA   Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA   Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA   Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA   Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA   Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA   Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA   Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA   Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA   Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA   Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA   Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA   Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA   Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA   Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA   Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA   Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA   Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA   Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA   Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA   Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA   Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA   Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA   Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA   Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA   Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA   Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA   Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA   Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA   Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA   Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA   Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA   Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2] {ECO:0000313|Ensembl:ENSCAFP00000037905}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000037905};
RG   Ensembl;
RL   Submitted (SEP-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCAFP00000037905}.
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DR   EMBL; AAEX03013493; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PaxDb; J9NX93; -.
DR   Ensembl; ENSCAFT00000048602; ENSCAFP00000037905; ENSCAFG00000005051.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   Reactome; R-CFA-5576892; Phase 0 - rapid depolarisation.
DR   Proteomes; UP000002254; Chromosome 23.
DR   Bgee; ENSCAFG00000005051; -.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008053; Na_channel_a5su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01666; NACHANNEL5.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002254};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002254};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18   1879       Sodium channel protein. {ECO:0000256|SAM:
FT                                SignalP}.
FT                                /FTId=PRO_5003825397.
FT   TRANSMEM     92    113       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    119    139       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    254    282       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    582    600       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    612    633       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    645    662       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    702    725       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    745    762       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    782    805       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1068   1087       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1108   1124       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1136   1157       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1185   1211       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1307   1333       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1392   1410       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1422   1440       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1452   1472       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1509   1537       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1612   1635       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN        1    288       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      344    531       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      582    809       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      819   1063       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1067   1342       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1391   1645       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      279    317       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1879 AA;  211685 MW;  99809F9426F04948 CRC64;
     MLIMCTILTN CVFMAQHDPP PWTKYVEYTF TAIYTFESLV KILARGFCLH AFTFLRDPWN
     WLDFSVIVMA YTTEFVDLGN VSALRTFRVL RALKTISVIS GLKTIVGALI QSVKKLADVM
     VLTVFCLSVF ALIGLQLFMG NLRHKCVRNF TALNDTNGSV EADGLVWESL DHYLSDSGNY
     LLKNGTSDVL LCGNSSDAGT CPEGYRCLKA GENPDHGYTS FDSFAWAFLA LFRLMTQDCW
     ERLYQQTLRS AGKIYMIFFM LVIFLGSFYL VNLILAVVAM AYEEQNQATI AETEEKEKRF
     QEAMEMLKKE HEALTIRGVD TVSRSSLEMS PLAPVTTHER RSKRRKRMSS GTEECGDDRF
     PKSDSEDGPR AMNRLSSTHG LSRTSVKPRS SRGSIFTFRR RDLGSETDFA DDENSTAGDS
     ESHRTSLLVP WPLRQPSAQG QLSPGTSAPA LNGKRNSTVD CNGVVSLLGA GDLEATSPGS
     HLLRPVILDR PPDTTTPSEE PGRPQMLTPQ APCVDGFEEP GERQRALSAV SVLTSALEEL
     EESHRKCPPC WNRFAQRYLI WECCPLWMSI KQRVKFMVMD PFADLTITMC IVLNTLFMAL
     EHYNMTAEFE EMLQVGNLVF TGIFTAEMTF KIIALDPYYY FQQGWNIFDS IIVILSLMEL
     GLSRMGNLSV LRSFRLLRVF KLAKSWPTLN TLIKIIGNSV GALGNLTLVL AIIVFIFAVV
     GMQLFGKNYS EQRHRISDSG LLPRWHMMDF FHAFLIIFRI LCGEWIETMW DCMEVSGQSL
     CLLVFLLVMV IGNLVVLNLF LALLLSSFSA DNLTAPDDDG EMNNLQLALA RIQRGLRFLK
     RTTWDFCCGL LQRPPKPTAL AAHGQLPGCM ATSSSPPPPE SQKVPPARKE TRFEEDKQPG
     QGTPGDTEPV CVPIAMAESD TDDQEEDEEN SLGTEEESSK QQESQPVSGS PEAVPERGAW
     SQVSETASSE ASVAQADWRQ QRKVEPPAPG CSEAPEDSYS EGSTADMTNT ADLLEQIPDL
     GEDVKDPEDC FTEGCVRRCP CCAVDTTQAP GKVWWRLRKT CYRIVEHSWF ETFIIFMILL
     SSGALAFEDI YLEERKTIKV LLEYADKMFT YIFVLEMLLK WVAYGFKKYF TNAWCWLDFL
     IVDVSLISLV ANTLGFAEMG PIKSLRTLRA LRPLRALSRF EGMRVVVNAL VGAIPSIMNV
     LLVCLIFWLI FSIMGVNMFA GKFGRCINQT EGDLPLNYTV VNNKSDCESF NVTGELYWTK
     VKVNFDNVGA GYLALLQVAT FKGWMDIMYA AVDSRGFEEQ PQWEYNLYMY IYFVIFIIFG
     SFFTLNLFIG VIIDNFNQQK KKLGGQDIFM TEEQKKYYNA MKKLGSKKPQ KPIPRPLNKY
     QGFLFDIVTK QAFDVTIMFL ICLNMVTMMV ETDDQSPEKV NILAKINLLF VAIFTGECII
     KMAALRHYYF TNSWNIFDFV VVILSIVGTV LSDIIQKYFF SPTLFRVIRL ARIGRILRLI
     RGAKGIRTLL FALMMSLPAL FNIGLLLFLV MFIYSIFGMA NFAYVKWEAG IDDMFNFQTF
     ANSMLCLFQI TTSAGWDGLL SPILNTGPPY CDPNLPNSNG SRGNCGSPAV GILFFTTYII
     ISFLIVVNMY IAIILENFSV ATEESTEPLS EDDFDMFYEI WEKFDPEATQ FIEYSALSDF
     ADALSEPLRI AKPNQISLIN MDLPMVSGDR IHCMDILFAF TKRVLGESGE MDALKIQMEE
     KFMAANPSKI SYEPITTTLR RKHEEVSATV IQRAFRRHLL QRSVKHASFL YRQQAGGARS
     GERAPEREGL IAYTMAENFS RRLGPPSSSS ISSTSSPPSY DSVTRATSDN PQVRASDYSR
     SEDLADLPPS PDRDRESIV
//
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