GenomeNet

Database: UniProt
Entry: J9P3Y7_CANLF
LinkDB: J9P3Y7_CANLF
Original site: J9P3Y7_CANLF 
ID   J9P3Y7_CANLF            Unreviewed;      4957 AA.
AC   J9P3Y7;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   30-AUG-2017, entry version 34.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSCAFP00000040266};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSCAFP00000040266};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000040266, ECO:0000313|Proteomes:UP000002254};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00000040266, ECO:0000313|Proteomes:UP000002254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000040266,
RC   ECO:0000313|Proteomes:UP000002254};
RX   PubMed=16341006; DOI=10.1038/nature04338;
RG   Broad Sequencing Platform;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA   Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA   Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA   Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA   Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA   Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA   Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA   Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA   Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA   Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA   Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA   Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA   Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA   Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA   Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA   Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA   Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA   Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA   Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA   Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA   Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA   Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA   Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA   Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA   Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA   Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA   Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA   Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA   Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA   Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA   Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA   Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA   Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA   Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA   Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2] {ECO:0000313|Ensembl:ENSCAFP00000040266}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000040266};
RG   Ensembl;
RL   Submitted (SEP-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCAFP00000040266}.
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DR   EMBL; AAEX03002669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03002670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03002671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03002672; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   DIP; DIP-60905N; -.
DR   PaxDb; J9P3Y7; -.
DR   Ensembl; ENSCAFT00000044598; ENSCAFP00000040266; ENSCAFG00000010034.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Reactome; R-CFA-2672351; Stimuli-sensing channels.
DR   Reactome; R-CFA-5578775; Ion homeostasis.
DR   Proteomes; UP000002254; Chromosome 4.
DR   Bgee; ENSCAFG00000010034; -.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002254};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002254};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4270   4289       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4490   4510       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4564   4583       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4700   4721       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4758   4779       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4834   4857       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      104    159       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      166    211       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      219    274       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      280    337       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      345    402       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      593    803       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1019   1216       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1331   1556       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4013   4048       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     4402   4426       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4957 AA;  562940 MW;  5E4D617F391B3951 CRC64;
     MTSARRGTRR PDAAGCSDDE VVLQCTATIH KEQQKLCLAA EGFGNRLCFL ESTSNSKNVP
     PDLSICTFVL EQSLSVRALQ EMLANTVEKS EGKFMMKTAQ GGGHRTLLYG HAILLRHSYS
     GMYLCCLSTS RSSTDKLAFD VGLQEDTTGE ACWWTIHPAS KQRSEGEKVR VGDDLILVSV
     SSERYLHLSY GNGSLHVDAA FQQTLWSVAP ISSGSEAAQG YLIGGDVLRL LHGHMDECLT
     VPSGEHGEEQ RRTVHYEGGA VSVHARSLWR LETLRVAWSG SHIRWGQPFR LRHVTTGKYL
     SLMEDKSLLL MDKENADVKS TAFTFRSSKE KLDVGVRKEV DGMGTSEIKY GDSVCYIQHI
     NTGLWLTYQS VDVKSVRMGS IQRKAIMHHE GHMDDGLNLS RSQHEESRTA RVIRSTVFLF
     NRFIRGLDAL SKKVRASTVD LPIESVSLSL QDLIGYFHPP DEHLEHEDKQ NRLRALKNRQ
     NLFQEEGMIN LVLECIDRLH VYSSAAHFAD VAGREAGESW KSILNSLYEL LAALIRGNRK
     NCAQFSGSLD WLISRLERLE ASSGILEVLH CVLVESPEAL NIIKEGHIKS IISLLDKHGR
     NHKVLDVLCS LCVCHGVAVR SNQHLICDNL LPGRDLLLQT RLVNHVSSMR PNIFLGVSEG
     SAQYKKWYYE LMVDHTEPFV TAEATHLRVG WASTEGYSPY PGGGEEWGGN GVGDDLFSYG
     FDGLHLWSGC IARTVSSPNQ HLLKTDDVIS CCLDLSAPSI SFRINGQPVQ GMFENFNIDG
     LFFPVVSFSA GIKVRFLLGG RHGEFKFLPP PGYAPCYEAV LPKEKLKVEH SREYKQERTY
     TRDLLGPTVS LTQAAFTPIP VDTSQIVLPP HLERIREKLA ENIHELWVMN KIELGWQYGP
     VRDDNKRQHP CLVEFSKLPE QERNYNLQMS LETLKTLLAL GCHVGISDEH AEEKVKKMKL
     PKNYQLTSGY KPAPMDLSFI KLTPSQEAMV DKLAENAHNV WARDRIRQGW TYGIQQDVKN
     RRNPRLVPYT LLDDRTKKSN KDSLREAVRT LLGYGYNLEA PDQDHAARAE VCSGTGERFR
     IFRAEKTYAV KAGRWYFEFE AVTAGDMRVG WSRPGCQPDQ ELGSDEHAFA FDGFKAQRWH
     QGNEHYGRSW QAGDVVGCMV DMTERTMMFT LNGEVLLDDS GSELAFKDFD VGDGFIPVCS
     LGVAQVGRMN FGKDVSTLKY FTICGLQEGY EPFAVNTNRD ITMWLSKRLP QFLQVPSNHE
     HIEVTRIDGT IDSSPCLKVT QKSFGSQNSS TDIMFYRLSM PIECAEVFSK TVAGGLPGTG
     LFGPKNDLED YDADSDFEVL MKTAHGHLVP DRVDKDKEAT KPEFNNHKDY AQEKPSRLKQ
     RFLLRRTKPD YSTSHSARLT EDVLADDRDD YDYLMQTSTY YYSVRIFPGQ EPANVWVGWI
     TSDFHQYDTG FDLDRVRTVT VTLGDEKGKV HESIKRSNCY MVCAGESMSP GQGRNNNGLE
     IGCVVDAASG LLTFTANGKE LSTYYQVEPS TKLFPAVFAQ ATSPNVFQFE LGRIKNVMPL
     SAGLFKSEHK NPVPQCPPRL HVQFLSHVLW SRMPNQFLKV DVSRISERQG WLVQCLDPLQ
     FMSLHIPEEN RSVDILELTE QEELLKFHYH TLRLYSAVCA LGNHRVAHAL CSHVDEPQLL
     YAIENKYMPG LLRAGYYDLL IDIHLSSYAT ARLMMNSEFI VPMTEETKSI TLFPDENKKH
     GLPGIGLSTS LRPRIQFSSP SFVSINNECY QYSPEFPLDI LKAKTIQMLT EAVKEGSLHA
     RDPVGGTTEF LFVPLIKLFY TLLIMGIFHN EDLKHILQLI EPSVFKEAAT PDEETEALEK
     EPCPEDSKSE GAGEEEAKGV KRPKEGLLQM KLPEPVKLQM CLLLQYLCDC QVRHRIEAIV
     AFSDDFVAKL QDNQRFRYNE VMQALNMSAA LTARKTKEFR SPPQEQINML LNFKDDKSEC
     PCPEEIRDQL LDFHEDLMTH CGIELDEDGS LDGNSDLTIR GRLLSLVEKV TYLKKKQAEK
     PIESDSKKSS TLQQLISETM VRWAQESVIE DPDLVRAMFV LLHRQYDGIG GLVRALPKTY
     TINGVSVEDT INLLASLGQI RSLLSVRMGK EEEKLMIRGL GDIMNNKVFY QHPNLMRALG
     MHETVMEVMV NVLGGGESKE ITFPKMVANC CRFLCYFCRI SRQNQKAMFD HLSYLLENSS
     VGLASPAMRG STPLDVAAAS VMDNNELALA LREPDLEKVV RYLAGCGLQS CQMLVSKGYP
     DIGWNPVEGE RYLDFLRFAV FCNGESVEEN ANVVVRLLIR RPECFGPALR GEGGNGLLAA
     MEEAIKIAED PSRDGPSPTS GSSKTLDTEE EEDDTIHMGN AIMTFYSALI DLLGRCAPEM
     HLIHAGKGEA IRIRSILRSL IPLGDLVGVI SIAFQMPTIA KDGNVVEPDM SAGFCPDHKA
     AMVLFLDRVY GIEVQDFLLH LLEVGFLPDL RAAASLDTAA LSATDMALAL NRYLCTAVLP
     LLTRCAPLFA GTEHHASLID SLLHTVYRLS KGCSLTKAQR DSIEVCLLSI CGQLRPSMMQ
     HLLRRLVFDV PLLNEHAKMP LKLLTNHYER CWKYYCLPGG WGNFGAASEE ELHLSRKLFW
     GIFDALSQKK YEQELFKLAL PCLSAVAGAL PPDYMESNYV SMMEKQSSMD SEGNFNPQPV
     DTSNITIPEK LEYFINKYAE HSHDKWSMDK LANGWIYGEI YSDSSKVQPL MKPYKLLSEK
     EKEIYRWPIK ESLKTMLAWG WRIERTREGD SMALYNRTRR ISQTSQVSVD AAHGYSPRAI
     DMSNVTLSRD LHAMAEMMAE NYHNIWAKKK KMELESKGGG NHPLLVPYDT LTAKEKAKDR
     EKAQDILKFL QINGYAVSRG FKDLELDTPS IEKRFAYSFL QQLIRYVDEA HQYILEFDGG
     GRSKGEHFPY EQEIKFFAKV VLPLIDQYFK NHRLYFLSAA SRPLCSGGHA SNKEKEMVTS
     LFCKLGVLVR HRISLFGNDA TSIVNCLHIL GQTLDARTVM KTGLESVKSA LRAFLDNAAE
     DLEKTMENLK QGQFTHTRNQ PKGVTQIINY TTVALLPMLS SLFEHIGQHQ FGEDLILEDV
     QVSCYRILTS LYALGTSKSI YVERQRSALG ECLAAFAGAF PIAFLETHLD KHNIYSIYNT
     KSSRERAALN LPTNVEDVCP NIPSLEKLME EIVELAESGI RYTQMPHVME VILPMLCSYM
     SRWWEHGPEN NPERAEMCCT ALNSEHMNTL LGNILKIIYN NLGIDEGAWM KRLAVFSQPI
     INKVKPQLLK THFLPLMEKL KKKAAMVVSE EDHLKAEARG DMSEAELLIL DEFTTLARDL
     YAFYPLLIRF VDYNRAKWLK EPNPEAEDLF RMVAEVFIYW SKSHNFKREE QNFVVQNEIN
     NMSFLITDTK SKMSKAAVSD QERKKMKRKG DRYSMQTSLI VAALKRLLPI GLNICAPGDQ
     ELIALAKNRF SMKDTEDEVR DIIRSNIHLQ GKLEDPAIRW QMALYKDLPN RTEDTSDPEK
     TVERVLDIAN VLFHLEQVEH PQRSKKAVWH KLLSKQRKRA VVACFRMAPL YNLPRHRAVN
     LFLQGYEKSW IETEEHYFED KLIEDLAKPG ADPPEEEEST KRVDPLHQLI LLFSRTALTE
     KCKLEEDFLY MAYADIMAKS CHDEEDDDGE EEVKSFEVTG SQRSKEKEME KQKLLYQQAR
     LHDRGAAEMV LQTISASKGD TGPMVAATLK LGIAILNGGN STVQQKMLDY LKEKKDVGFF
     QSLAGLMQSC SVLDLNAFER QNKAEGLGMV TEEGSGEKVL QDDEFTCDLF RFLQLLCEGH
     NSDFQNYLRT QTGNNTTVNI IISTVDYLLR VQESISDFYW YYSGKDVIDE QGQRNFSKAI
     QVAKQVFNTL TEYIQGPCTG NQQSLAHSRL WDAVVGFLHV FAHMQMKLSQ DSSQIELLKE
     LMDLQKDMVV MLLSMLEGNV VNGTIGKQMV DMLVESSNNV EMILKFFDMF LKLKDLTSSD
     TFKEYDPDGK GVISKRDFHK AMESHKHYTQ SETEFLLSCA ETDENETLDY EEFVKRFHEP
     AKDIGFNVAV LLTNLSEHMP NDTRLQTFLE LAESVLNYFQ PFLGRIEIMG SAKRIERVYF
     EISESSRTQW EKPQVKESKR QFIFDVVNEG GEKEKMELFV NFCEDTIFEM QLAAQISESD
     LNERSVSKEE SEKEKPEEQG PRMGFFSILT VKSALLALRY NVLTLMRMLS LKSLKKQMKR
     VKKMTVKDMV MAAFSSYWNI FMSLLHFVAS VSRGFFRIIC SLLLGGSLVE GAKKIRVAEL
     LANMPDPTQD EVRGDSEEGD RKPMEAALPS EDLTDLKELT EESDLLSDIF GLDLKREGGQ
     YKLIPHNPNA GLSDLMSNPV PIPDVQEKFQ EQKAKEEEKE EKEENKSEPE KAEGEDGEKE
     EKAKEDKGKQ KLRQLHTHRY GEPEVPESAF WKKIIAYQQK LLNYFARNFY NMRMLALFVA
     FAINFILLFY KVSTSSVVEG KELSTRSSSE NAKVSSLDSG SPRIITVHYV LEESSGYMEP
     TLRILAILHT VISFFCIIGY YCLKVPLVIF KREKEVARKL EFDGLYITEQ PSEDDIKGQW
     DRLVINTQSF PNNYWDKFVK RKVMDKYGEF YGRDRISELL GMDKAALDFS DAREKKKPKK
     DSSLSAVLNS IDVKYQMWKL GVVFTDNSFL YLAWYMTMSI LGHYNNFFFA AHLLDIAMGF
     KTLRTILSSV THNGKQLVLT VGLLAVVVYL YTVVAFNFFR KFYNKSEDGD TPDMKCDDML
     TCYMFHMYVG VRAGGGIGDE IEDPAGDEYE IYRIIFDITF FFFVIVILLA IIQGLIIDAF
     GELRDQQEQV KEDMETKCFI CGIGNDYFDT VPHGFETHTL QEHNLANYLF FLMYLINKDE
     TEHTGQESYV WKMYQERCWE FFPAGDCFRK QYEDQLN
//
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