GenomeNet

Database: UniProt
Entry: J9PAI1_CANLF
LinkDB: J9PAI1_CANLF
Original site: J9PAI1_CANLF 
ID   J9PAI1_CANLF            Unreviewed;      1777 AA.
AC   J9PAI1;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   30-AUG-2017, entry version 39.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN11A {ECO:0000313|Ensembl:ENSCAFP00000042808};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000042808, ECO:0000313|Proteomes:UP000002254};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00000042808, ECO:0000313|Proteomes:UP000002254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000042808,
RC   ECO:0000313|Proteomes:UP000002254};
RX   PubMed=16341006; DOI=10.1038/nature04338;
RG   Broad Sequencing Platform;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA   Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA   Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA   Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA   Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA   Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA   Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA   Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA   Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA   Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA   Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA   Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA   Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA   Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA   Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA   Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA   Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA   Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA   Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA   Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA   Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA   Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA   Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA   Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA   Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA   Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA   Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA   Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA   Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA   Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA   Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA   Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA   Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA   Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA   Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2] {ECO:0000313|Ensembl:ENSCAFP00000042808}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000042808};
RG   Ensembl;
RL   Submitted (SEP-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCAFP00000042808}.
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DR   EMBL; AAEX03013493; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03013494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9615.ENSCAFP00000042808; -.
DR   PaxDb; J9PAI1; -.
DR   Ensembl; ENSCAFT00000047954; ENSCAFP00000042808; ENSCAFG00000029139.
DR   eggNOG; ENOG410INF8; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; J9PAI1; -.
DR   OMA; CYQIVKH; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000002254; Chromosome 23.
DR   Bgee; ENSCAFG00000029139; -.
DR   GO; GO:0044299; C:C-fiber; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0051930; P:regulation of sensory perception of pain; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028821; Na_channel_a11su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF229; PTHR10037:SF229; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002254};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002254};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    133    152       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    164    186       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    198    215       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    236    257       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    263    282       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    380    399       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    585    603       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    615    638       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    650    669       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    708    731       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    789    815       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1047   1065       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1086   1105       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1111   1130       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1156   1182       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1277   1300       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1350   1373       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1393   1411       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1423   1441       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1478   1506       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1526   1549       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1570   1596       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      133    416       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      585    824       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      832   1041       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1045   1309       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1357   1606       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      410    441       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1777 AA;  203393 MW;  E54B30957E97BDAD CRC64;
     MDDRCYPVIF PDERNFRPFT SDTLATIEKR IAIQKEKKRC KDKTTAEPQP RPQLDLKVSR
     KLPKLYGDIP HELIARPLED LDPFYRNHKT FMVLNKKRTI YRFSAKRALF ILGPFNPIRS
     LAIKISVHSS ITLFSMFIIC TVIINCVFMA TAHGKDKNNT DTDNAEYVFT GIYIFEALIK
     ILARGFILDE FSFLRDPWNW LDSIVIVTAF VSYSPNTILN NSISMSSLRT FRVFRALKAI
     SVVSGLKVIV GALLRSVKKL VDVMILTLFC LSIFALVGQQ LFMGSLNQRC IKASCTDINK
     LSGFSYSCFE KKNSSEFRMC GIWMGESACS EGFQCNHTKR NPDYNYTNFD NFGWSFLAMF
     RLMTQDSWEK LYQQTLRASG LFSVFFFVVV IFLGSFYLIN LTLAVVTMAY EEQNRNVAAE
     TEAKEKMFQE AQRLLKEEKE ALVAMGIDRS SLNSLEASSF SSKKRKLFGN RKRKSFFLRD
     SGKDQTPGSD SDEDSTKKPH ILEQTKRLSQ NLSVDYCDDH GDPFQRQRAL SAVSILTITM
     QEQEKSQEPC LPCGENLASR YLVWNCSPRW LCIKKALRTV MTDPFTELAI TVCIIINTVF
     LAMEHYKMDQ SFESILYTGN LVFTGIFMAE MCLKIIALDP YNYFRRGWNI FDSIVALLSF
     VDVMINIIVG KQCPRVFHSL RVLRVFKLAK SWPTLNTLIK IIGHSVGALG NLTVVLAIVV
     FIFSVVGMQL FGSQFNSVKS NRRSCNPTVP CLRRWHMGDF YHSFLVVFRI LCGEWIENMW
     ECMQETNQTL CIVVFLLIMV IGKLVVLNLF IALLLNSFSN EERDGNLDGE SKKTKVQLAL
     DRFHRVFCIV IYTLEHFCHK WCRTQNSPKR TKVTGGPAAQ SKDIIPLVTE MKRGPETREE
     HDQTWLAPLA EEEDGFESSG ENNAQHITQP EAGKQAFEFH RETKKSTSPG AQSVEIDVFS
     EDDICLSKQD PQKKSDTASV FSECSTIDPQ DPFGRVTEMV LKKEPERCFP KGLGHCFPCC
     SMNKRKSPWI IWWNLRKTCY QIVKHSWFES FIIFVILLSS GALVFEDIYL EERPNIRDLL
     NCTDHIFTYI FILEMGLKWV AFGFGKYFTS VWCWLDFIIV IVSVTSLIDL KSLKSFRTLR
     ALRPLRALSQ FQGMKVVVNA LIGAIPAILN VLLVCLIFWL IFCILGVNFF SGKFGRCINR
     TDINSVINYS TIANQSQCEG GNLSWVNLPV NFDNVGMAYL ALLQVATFKG WMDIMYAAVD
     SRGKEQQPGF EESPYNYLFF VAFIIFGSFF TLNLFIGVII DNFNQQQKKL GGEDIFMTEE
     QKKYYNAMKK LGSKKPQKPI PRPLNKCQGL MYDLVTNQVF DVIIIILIFL NMLSMMAESE
     NQLDTTKFIL DRLNLAFVVI FTIECLIKIF ALRQYYFTIG WNLFDCVIVV LSIVSTMVSA
     LENQEHIPFP PTLFRIVRLA RIGRILRLVR AARGIRTLLF ALMMSLPSLF NIGLLLFLVM
     FIYAIFGMNC FCKVNEEFGI DDIFNFKTFV GSILCLFQIT TSAGWDALLR PMLQSKDSCN
     PNLDSRHLPA IAITYFVSYI IISFLIVVNM YIAVILENFN TATEESEDPL GEDDFEIFYE
     VWEKFDPEAT QFIKYSALSD FADALPEPLR VAKPNKFQFL MMDLPMVSGD RLHCLDILFA
     FTTRVLGDSS GLDNMKVMME EKFMEANPSK KLYEPIVTTT KRKEEERCAA IIQKAFRKYK
     VKMSTYALED RPGSPLHTLC NGDLSGSGVA EGKVHYD
//
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