ID   J9Q4I5_OSTED            Unreviewed;       129 AA.
AC   J9Q4I5;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=proton-translocating NAD(P)(+) transhydrogenase {ECO:0000256|ARBA:ARBA00012943};
DE            EC=7.1.1.1 {ECO:0000256|ARBA:ARBA00012943};
DE   Flags: Fragment;
OS   Ostrea edulis (Native oyster) (European flat oyster).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Ostrea.
OX   NCBI_TaxID=37623 {ECO:0000313|EMBL:AFJ91740.1};
RN   [1] {ECO:0000313|EMBL:AFJ91740.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=D6-07S67_5793 {ECO:0000313|EMBL:AFJ91740.1};
RX   PubMed=22833317; DOI=10.1007/s10126-012-9472-1;
RA   Martin-Gomez L., Villalba A., Carballal M.J., Abollo E.;
RT   "Identification of relevant cancer related-genes in the flat oyster Ostrea
RT   edulis affected by disseminated neoplasia.";
RL   Mar. Biotechnol. 15:159-174(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+);
CC         Xref=Rhea:RHEA:47992, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:57945, ChEBI:CHEBI:58349; EC=7.1.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000006};
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DR   EMBL; JN091798; AFJ91740.1; -; mRNA.
DR   AlphaFoldDB; J9Q4I5; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR034300; PNTB-like.
DR   PANTHER; PTHR10160; NAD(P) TRANSHYDROGENASE; 1.
DR   PANTHER; PTHR10160:SF19; PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE; 1.
DR   Pfam; PF02233; PNTB; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
PE   2: Evidence at transcript level;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   NAD {ECO:0000256|ARBA:ARBA00023027}; NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Translocase {ECO:0000256|ARBA:ARBA00022967};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          3..120
FT                   /note="NADP transhydrogenase beta-like"
FT                   /evidence="ECO:0000259|Pfam:PF02233"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AFJ91740.1"
SQ   SEQUENCE   129 AA;  13934 MW;  B5171473C6F489E0 CRC64;
     TRGIHPVAGR MPGQLNVLLA EAGVPYDIVL EMDEINDDFP ETDLVLVIGA NDTVNSAAEE
     DPNSIIAGMP VLRVWGSKHV IVMKRTLGVG YAAVDNPIFF KNNTSMLLGD AKKTCDALLT
     KIKEHYGEA
//