ID J9RUI5_9ACTN Unreviewed; 1010 AA.
AC J9RUI5;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Putative drug exporters, RND superfamily {ECO:0000313|EMBL:AFR51602.1};
GN ORFNames=KTR9_5389 {ECO:0000313|EMBL:AFR51602.1};
OS Gordonia sp. KTR9.
OG Plasmid pGKT3 {ECO:0000313|EMBL:AFR51602.1,
OG ECO:0000313|Proteomes:UP000003281}.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC Gordonia.
OX NCBI_TaxID=337191 {ECO:0000313|EMBL:AFR51602.1, ECO:0000313|Proteomes:UP000003281};
RN [1] {ECO:0000313|EMBL:AFR51602.1, ECO:0000313|Proteomes:UP000003281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KTR9 {ECO:0000313|EMBL:AFR51602.1,
RC ECO:0000313|Proteomes:UP000003281};
RC PLASMID=pGKT3 {ECO:0000313|EMBL:AFR51602.1,
RC ECO:0000313|Proteomes:UP000003281};
RX PubMed=22923396; DOI=10.1128/AEM.02120-12;
RA Chen H.P., Zhu S.H., Casabon I., Hallam S.J., Crocker F.H., Mohn W.W.,
RA Indest K.J., Eltis L.D.;
RT "Genomic and transcriptomic studies of an RDX (hexahydro-1,3,5-
RT trinitro-1,3,5-triazine)-degrading actinobacterium.";
RL Appl. Environ. Microbiol. 78:7798-7800(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; CP002909; AFR51602.1; -; Genomic_DNA.
DR RefSeq; WP_014928953.1; NC_018583.1.
DR AlphaFoldDB; J9RUI5; -.
DR KEGG; gor:KTR9_5389; -.
DR PATRIC; fig|337191.3.peg.5384; -.
DR HOGENOM; CLU_005108_3_2_11; -.
DR Proteomes; UP000003281; Plasmid pGKT3.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR023908; xxxLxxG_rpt.
DR NCBIfam; TIGR03057; xxxLxxG_by_4; 1.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Plasmid {ECO:0000313|EMBL:AFR51602.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 208..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 836..855
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 862..887
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 893..913
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 934..960
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 966..999
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 233..363
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1010 AA; 107199 MW; A2D43C23913082DA CRC64;
MVSSSPIRTR PSRGGEKLGE YSPTLERVAW FTLRRKGIVT LVWLGAAIGL GLLFPQLESV
IREQSVDPIP AGVPSFQTLD RMGASFDERG AKTTVFVVME NSAGLSDNTR DRYHVLVDTL
RADDRHVIAV RDLLSDPLTA SQALSKDKQA WYLPVGVAGT LGGPDTAEAV AAVREIAESI
FRDSGTTVRV TGPPATFSDQ LAVGESDLVL ITVATVLLIA VILLIVYRSV FTALMPLLVV
GMSLAVGRGV LSGLGELGMP VSQFTSMFMT VIIFGAGVDY SVFLISRYHE GIRAGYSPDV
AIAHANATIG RVVLASAGTV ALAFLAMAFA KLSVFNTLGP ACAIAIAFAF LATVTLLPLV
LSFAAKKGAG LPRRDLTRDY WRRVGVMVIR RPVPLLAISV VVLIGLAMVA ATIQITYDDR
EGQPPDTGSN EGYALLNRHF PKDIIISEFL VVESENDMRT AQGLADLDQL ASRVAQIPGV
TRVIGVTRPT GEKLEQAQLS WQNDQIGTKI TEETGDGQAR KGDLAVLKTG SEQLAGGLAL
LEDQISSNLA PLSGLLDEVS SFGPQLDEYR PLVNQLANAA PRLRQFSKQA PELSQLARRA
QSAADAVAPA LSALDNPWCQ QIAQCSALRA QMADIRALAD DQSLGRVADF AAQLGRVSAP
GSTNIAQLQR SLQTLDSALQ AIGGQDLGNR LSQLESGVGA LADGARQLSN GVGALVDSNL
QLLSGLAQVA AQLRAPAREV GDSDSATGFY LPADAFKDQQ FSQVARQFIS SDGKTVRYAV
QTAYDPYSAD AMTLANELSS VAENAMPNTT LEGGRASVAG FPAINADVQR LLSYDFKLLG
IATLLIVGLI LMLLLRAVVA PVYLLATVVL NYMAALGIGV LVLQHILGAG IAWPVPLVSF
IVLVAVGADY NMLLVSRLRE ETRWSVRVGV MRTVAYTGSV ITSAGLIFAA SMFGLMVGSI
DVMVQIGFII GVGLLLDTFL VRTLVVPALA VLLGTASWWP GDIDRFRLAP
//
