ID J9VKV6_CRYNH Unreviewed; 543 AA.
AC J9VKV6;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 22-FEB-2023, entry version 42.
DE RecName: Full=Carboxypeptidase {ECO:0000256|RuleBase:RU361156};
DE EC=3.4.16.- {ECO:0000256|RuleBase:RU361156};
GN ORFNames=CNAG_01040 {ECO:0000313|EMBL:AFR95107.1};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR95107.1, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR95107.1, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
CC -!- SIMILARITY: Belongs to the peptidase S10 family.
CC {ECO:0000256|ARBA:ARBA00009431, ECO:0000256|RuleBase:RU361156}.
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DR EMBL; CP003824; AFR95107.1; -; Genomic_DNA.
DR RefSeq; XP_012049277.1; XM_012193887.1.
DR AlphaFoldDB; J9VKV6; -.
DR MEROPS; S10.006; -.
DR GeneID; 23884786; -.
DR KEGG; cng:CNAG_01040; -.
DR VEuPathDB; FungiDB:CNAG_01040; -.
DR HOGENOM; CLU_008523_12_3_1; -.
DR OrthoDB; 1647009at2759; -.
DR Proteomes; UP000010091; Chromosome 5.
DR GO; GO:0004185; F:serine-type carboxypeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001563; Peptidase_S10.
DR InterPro; IPR033124; Ser_caboxypep_his_AS.
DR InterPro; IPR018202; Ser_caboxypep_ser_AS.
DR PANTHER; PTHR11802:SF479; CARBOXYPEPTIDASE; 1.
DR PANTHER; PTHR11802; SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE; 1.
DR Pfam; PF00450; Peptidase_S10; 1.
DR PRINTS; PR00724; CRBOXYPTASEC.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS00560; CARBOXYPEPT_SER_HIS; 1.
DR PROSITE; PS00131; CARBOXYPEPT_SER_SER; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645,
KW ECO:0000256|RuleBase:RU361156};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361156};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU361156};
KW Signal {ECO:0000256|RuleBase:RU361156}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|RuleBase:RU361156"
FT CHAIN 22..543
FT /note="Carboxypeptidase"
FT /evidence="ECO:0000256|RuleBase:RU361156"
FT /id="PRO_5005137164"
SQ SEQUENCE 543 AA; 61218 MW; 44F2BCB68101328A CRC64;
MWSKILTTAL LVFALGSVVG AARDPLGLRG RRPAVLAAKK EAKREALAGE MLRMEESRAL
VEKHREKKFY NNKTSEFFVY SLPDVPCELG ETYSGLIPID HRNQSEALFF VFQPKLGKAS
NDLTIWLNGG PGCSSLEGWF QENGLWTWKP GTYAPVVNPY SWVNLTNMLW VEQPIGTGFS
IGTPKAKTEE EIALDFIKWF KNFQNLFGIK NYKIYVTGES YAGRYVPYIS AAMLDAKDKT
YYNLCGALMY DPTIGETITV QEMIPTYPFV EANSNLFSFN KTIMAELKDI HESCGYKEYI
DRYLKFPPTE NQPPLFFNYS DPKNITCAIL DMVNELAFHV NPCFNIYGVN LMCPFLWDVL
GMPTQLNYAP GGVYFNRSDV KAAMHAPQHI DWAGCAAIPV FVGGEDGPQG NGDLSRDPIQ
EVLPKVIEAT NRVLVSNGDL DMVIITNGTL LAIQNMTWNG KLGFQSAPSE YIFIDIDDTE
WPPVFDSNGF DGYPGTQGVM GIQHYERGLM WAETFQSGHM QPQYQPRSTY RHLQWLLGHI
DKL
//
