ID J9VLA9_CRYNH Unreviewed; 746 AA.
AC J9VLA9;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Anaphase-promoting complex subunit 3 {ECO:0000313|EMBL:AFR92455.2};
GN ORFNames=CNAG_00320 {ECO:0000313|EMBL:AFR92455.2};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR92455.2, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR92455.2, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
CC -!- SIMILARITY: Belongs to the APC3/CDC27 family.
CC {ECO:0000256|ARBA:ARBA00038210}.
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DR EMBL; CP003820; AFR92455.2; -; Genomic_DNA.
DR RefSeq; XP_012046258.1; XM_012190868.1.
DR AlphaFoldDB; J9VLA9; -.
DR GeneID; 23884139; -.
DR KEGG; cng:CNAG_00320; -.
DR VEuPathDB; FungiDB:CNAG_00320; -.
DR HOGENOM; CLU_008850_4_0_1; -.
DR OrthoDB; 152021at2759; -.
DR Proteomes; UP000010091; Chromosome 1.
DR GO; GO:0005680; C:anaphase-promoting complex; IEA:UniProt.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12558; CELL DIVISION CYCLE 16,23,27; 1.
DR PANTHER; PTHR12558:SF13; CELL DIVISION CYCLE PROTEIN 27 HOMOLOG; 1.
DR Pfam; PF12895; ANAPC3; 1.
DR Pfam; PF00515; TPR_1; 1.
DR Pfam; PF14559; TPR_19; 1.
DR Pfam; PF13181; TPR_8; 3.
DR SMART; SM00028; TPR; 7.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 5.
PE 3: Inferred from homology;
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 132..165
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 524..557
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 558..591
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 592..625
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 694..727
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 192..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..365
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..409
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 746 AA; 82306 MW; C845D66F300D6564 CRC64;
MNTHLAARLQ HLVSAYPPHT ALFYARIWHT LAPTTDSNHD SLHALALAFL QAAEPYSAIH
LVRDHTGLDN LDLDLEIRFE RSDKVCGGCA VIVARCCEKL GRYSEGQAVL ARALKRGANI
NLALPASSSN AAAAYLLLAN LSHKGKSPET AIENYRKALD EDPWMWEAFT NLCDVGAPPP
IESLFPSGAG LSLSRHASRS SRPPLSPNIH RQKSPIEPAP GVLRLHQAQA GAGNNGGLFT
PDVEGIGGKT TLGMMGNPSS WDTSSIMGDA TFALPEQPTK RPFPSFMSTA TSFLPSSLRG
GTSTPAGNDS PPKLPTMKRP RGKDPVKRPV ETPQSQMSSG LPLAKELRPN GAKYEDSDAP
RRSSRLKTTT SKPAPKVPRD PHATRSRSVT SSNSNNEVPS PPSLTSQDTI LQKEADEYLK
DIVKKCARIY KSLSGYQCQQ AIKEVDALPG ELKTSPWAME ILGRAFYEIA NYAMARRAFT
FLQQQEPYRI QSMEQLSTLL WHLADLPALS HLSQSLISIS RSSPQAWIAV GNCFSLQKDH
DEAMRCFRRA TQVDEGCAYA WTLCGYEAVE MEEYERAMAF YRTAIRTDAR HYNAWYGMGL
VYLKTDRPRY AEHHFRRAVE INPTNPVLLC CVGMALEKSD DVVQALHFYE RASKYAPTSA
MVQFKRIRAL VALQRYDEAI SALVPLTHSA PDEANVFFLL GKCLLKKERR QEATMAFTNA
RELEPKLEGA INAVLAANGE EGEDQE
//
