ID J9VLD1_CRYNH Unreviewed; 1313 AA.
AC J9VLD1;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Cyclin-dependent protein kinase inhibitor {ECO:0000313|EMBL:AFR95292.2};
GN ORFNames=CNAG_02541 {ECO:0000313|EMBL:AFR95292.2};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR95292.2, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR95292.2, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
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DR EMBL; CP003825; AFR95292.2; -; Genomic_DNA.
DR RefSeq; XP_012049680.1; XM_012194290.1.
DR GeneID; 23886155; -.
DR KEGG; cng:CNAG_02541; -.
DR VEuPathDB; FungiDB:CNAG_02541; -.
DR HOGENOM; CLU_002842_0_1_1; -.
DR OrthoDB; 4907at2759; -.
DR PHI-base; PHI:11022; -.
DR Proteomes; UP000010091; Chromosome 6.
DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd14483; SPX_PHO81_NUC-2_like; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR030395; GP_PDE_dom.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR InterPro; IPR004331; SPX_dom.
DR PANTHER; PTHR24161; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR24161:SF85; LD20463P-RELATED; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF03009; GDPD; 1.
DR Pfam; PF03105; SPX; 2.
DR SMART; SM00248; ANK; 7.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS51704; GP_PDE; 1.
DR PROSITE; PS51382; SPX; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00023315}.
FT DOMAIN 1..240
FT /note="SPX"
FT /evidence="ECO:0000259|PROSITE:PS51382"
FT REPEAT 436..468
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 522..554
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 554..580
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 981..1313
FT /note="GP-PDE"
FT /evidence="ECO:0000259|PROSITE:PS51704"
FT REGION 59..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 973..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..85
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..989
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1313 AA; 141577 MW; 0846F77EF94DB02E CRC64;
MKFGKTIQSQ QVPGWGEYYL NYKALKKIIN SYAAGRPASD ASLLSLGLRP ARLPVAITDT
NTTSSLPNSS HPPSSSDTST DAEHVNIQDL EPLPPQTAPP GNTSSGLMGR NPMEGAGRSE
SFKAHRDVFF FTLQRELEKI NAFYLIKERD LRLRLLSLLS NRKRLLQNSS STTPDTSDGL
SPTGVRRDAE WASLEEGWRL FERDLGKLQG FIEINATGFR KILKKWDKRS KSNTKELYLE
RQVEVQPCFN REFIAKLSDI VAANLIDVEN GSEHISTAFL ERDPSSLGGA NFASTEVMAG
GVGVGSNRSV DFDIDSTRAL ALDALADLEA NLTKAISAGQ DALIDWVKVA HARQQRQRFS
QSTTDPSLMR ILWQCALHAP PTLLPFVLSS LELDYNCIDN INGRSILHKA CIVGSLPLVE
HCVENSPGLV EKNDVYERRP LHYAAMHGFA EIVSFLLQTS SNPSATGHRE AAEPSPTDMD
GYTPLMHAIQ RGHLAVVQIF VSDEITGGAR ERITLEPTAM SNDLIPLSLA CEHGHVEVAR
LLLQRGARVI PNSEGLYPQH FAAKAGHSAI CQLLVEEGGE EGGGKDRKDK YNLWTPLHHA
AIGGEERHLE CVKVLVEKGG CDVNVPDEYG KSAGWYAAWF GHVECLNYLR DHGARLGGSR
GGDVSSTGIG GAGAQAGGRR EDGGEMEDKM KVDEMGGLGL AADPQMGALS PGSDLELDPP
AEEFELIPSL SLPPPIIPLR VYGHEFLAQR CLIQLSLGHR ITSSFPPCNS NTPTHTHPHA
PAIKLYSRSG SGQDSLHLWS SLKLVMTSKS DISAVPHSVI LPLADEREVF SFHAQDLDRF
TLELSLYPTF GSKVIGRAIL LPGTWKDIKY HKQLQAPLLD HNLKAIGEVA LEVSCITPFE
GAQLEIGGRV ETYWKSKVVK GDSAQDHAHL APHKPLSVFS SSGAVAGDIG AAAAGAVGHG
VSLEGGKMND MGVSSGADTG MSTVPATGAA SSGGGGESAL VTASSLSGEY VHVVVQVTKD
GVPVVYPHGR LPVKEFDLGV SDATYDQFMA LATRLGLALQ PPSSLDYQPT TSDWYNLLSS
TLSSLTDVLT LLPHEIGINL RLRYTREVDS SSVGKKVGRE SGEVNKWVDS VLDSVYEVGK
KVGGEGGKAR KIIFSSFDPV VCTALNWKQP NYAVFFASYC GVSRQSSLPA STSIRTSDED
TTHSPSPYIT GEHGYGGRRT RRLIPAPREE ESDVRCLSVR EAVNFAKSRN LLGVILEAST
LSAVPSLVAS VKDAGLLLAA FGEPADIGVL RQGADDGRTI DAFVLEGIMT LTI
//
