ID   J9VLT6_CRYNH            Unreviewed;       699 AA.
AC   J9VLT6;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 2.
DT   22-FEB-2023, entry version 38.
DE   SubName: Full=Cell division control protein 45 {ECO:0000313|EMBL:AFR95427.2};
GN   ORFNames=CNAG_02406 {ECO:0000313|EMBL:AFR95427.2};
OS   Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS   CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR95427.2, ECO:0000313|Proteomes:UP000010091};
RN   [1] {ECO:0000313|EMBL:AFR95427.2, ECO:0000313|Proteomes:UP000010091}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC   {ECO:0000313|Proteomes:UP000010091};
RX   PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA   Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA   Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA   Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA   Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA   Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA   Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA   Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA   Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA   Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA   Cuomo C.A., Dietrich F.S.;
RT   "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT   grubii reveals complex RNA expression and microevolution leading to
RT   virulence attenuation.";
RL   PLoS Genet. 10:E1004261-E1004261(2014).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the CDC45 family.
CC       {ECO:0000256|ARBA:ARBA00010727}.
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DR   EMBL; CP003825; AFR95427.2; -; Genomic_DNA.
DR   RefSeq; XP_012049730.1; XM_012194340.1.
DR   AlphaFoldDB; J9VLT6; -.
DR   GeneID; 23886030; -.
DR   KEGG; cng:CNAG_02406; -.
DR   VEuPathDB; FungiDB:CNAG_02406; -.
DR   HOGENOM; CLU_005871_3_0_1; -.
DR   OrthoDB; 1407079at2759; -.
DR   Proteomes; UP000010091; Chromosome 6.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   InterPro; IPR003874; CDC45.
DR   PANTHER; PTHR10507; CDC45-RELATED PROTEIN; 1.
DR   PANTHER; PTHR10507:SF0; CELL DIVISION CONTROL PROTEIN 45 HOMOLOG; 1.
DR   Pfam; PF02724; CDC45; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000313|EMBL:AFR95427.2};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT   REGION          173..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        181..209
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        210..244
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   699 AA;  78761 MW;  E2B839BF160B0087 CRC64;
     MPVVQPPADG LRPSDLTYTH AYNSIVSRVR RTAGAASGGV VILAGVDVDG LLGARILCSL
     FKNDDIPYRL IPVGGLTELE EKSDEALASE EIHTLILVSL GSLLTLTDFF NLPKKVHLHV
     LDSHRPWNLG NLFDIDLDDE DDEDAHGKIW IWGDGDEFSE NMDQLRKSFE ALQFLPQKDS
     DEDSDSDEES EAEEEEPEEE DEEGGDDVED EEGGSRKRRR EDSIPARRKR LRDNDRPRKL
     PKAIKEAHQE RIAKYYNHGT YYGQSVALTI YLLATVLERA DNDILWYSIL GVTHQYITSH
     IDRERYEEYH TIFLDEVVRL NHEPDLGALQ TPNPDNRNIS KSEELRFMLF RHWDLYNAML
     HSGYVAGRLG IWKEKGRSKL RGLLAKMGYS IQQCNQAWSH MDMELKRQLP EVLERVGPEY
     GLVELSYPSF TRAYGFQLSS LSAADAVEVI SSLLDIAVGV RLEVDREGGK GGGEWFGGTT
     RWSVGTREAE MGIIASEPGE RAEGTEGEES EEKKDQDWHV TNFWIAYDAC DDVPLLRRSL
     PLAMALHRAI IRAGSDLLDK SIIRTLRNFR LTILSEGPDL RLFCHPSPLS RLALWLVDAT
     RDRWVEKLAR QNAHSGGKVK SLPFVVACLN EEKGTFSVVG VTGAPEFGDV RKNKFGLAFQ
     QAASFSNATA SLDMFDTSVV EVGREDLQSF IEHLHLHSV
//