ID J9VND8_CRYNH Unreviewed; 727 AA.
AC J9VND8;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=U2-associated protein SR140 {ECO:0000313|EMBL:AFR95972.2};
GN ORFNames=CNAG_06685 {ECO:0000313|EMBL:AFR95972.2};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR95972.2, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR95972.2, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
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DR EMBL; CP003826; AFR95972.2; -; Genomic_DNA.
DR RefSeq; XP_012050322.1; XM_012194932.1.
DR AlphaFoldDB; J9VND8; -.
DR GeneID; 23889863; -.
DR KEGG; cng:CNAG_06685; -.
DR VEuPathDB; FungiDB:CNAG_06685; -.
DR HOGENOM; CLU_010743_3_0_1; -.
DR OrthoDB; 9814at2759; -.
DR Proteomes; UP000010091; Chromosome 7.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 1.10.10.790; Surp module; 1.
DR InterPro; IPR006569; CID_dom.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR000061; Surp.
DR InterPro; IPR035967; SWAP/Surp_sf.
DR PANTHER; PTHR23140; RNA PROCESSING PROTEIN LD23810P; 1.
DR PANTHER; PTHR23140:SF0; U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN; 1.
DR Pfam; PF04818; CID; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF01805; Surp; 1.
DR SMART; SM00582; RPR; 1.
DR SMART; SM00360; RRM; 1.
DR SMART; SM00648; SWAP; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR SUPFAM; SSF109905; Surp module (SWAP domain); 1.
DR PROSITE; PS51391; CID; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS50128; SURP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 203..288
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 362..405
FT /note="SURP motif"
FT /evidence="ECO:0000259|PROSITE:PS50128"
FT DOMAIN 450..598
FT /note="CID"
FT /evidence="ECO:0000259|PROSITE:PS51391"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 114..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 684..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 612..639
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..57
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..150
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..327
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..727
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 727 AA; 81006 MW; EB45F48ADAC1F34B CRC64;
MSRRLDLSKF AGSDSEGEED VPKHQLELTA LKSKTFSQGI TKKTKRDLEK EAEERKRIEE
EKAAALVMAE IEREFEGSAE GSSSGHAGMR GFRGRPIGPG GGFVRAGGAP MGAPMSFAPP
RGPAAMGYGR PKPMPVRAPS PPPPPSGPKP RGKRAMDSFL EEIKHNQNAR EQKFSQIAKK
EGSSVTALAA WETGGSGFDH ESTNLFISNL PQEITEEILG LHFAKQGPVA TVKIMWPRGD
EAFSQASTRR GLTGFVSYME RKDAERAVKE LDGSEWMGNS IRVGWSKPVA KPLKALFDIT
SDNHKRRRSR SRSRDRSPPR KKSHRSRSYS YSSSSSYSRS PSPRRTSKEK WLDSIPEEHR
RFIKTVANRV KEHGKGFEGV LMEKERENPK FAFLYDDKLP DYHLYQSTLS SHHRIPSPPP
ETFNDDGYAS LYSSDLAEDS EKERTSKGKL GRLARRRFEA MLRVMTGKRA EIARGMEFAL
KRAEAADEIA DIICQSVQVD STPVPRKIAR LHLISDILHN SASPLPNVWR YRHAFEHRLP
PVLAHLNTVE KSLMAYSGKI SADVFRGQVG NVLDIWERWI VFNTDTAELF RAVLVGDKPL
SALVKTPQGV WVDKAKLEAA EEAQRKMEET QKVEEEEDKF ERSGFKSSFK RINPQAAPVA
VAVAASASAP VAAGESVPLA VRSLFEDEDL DGEAMEDLDG EQMEDLDGEQ MEDLDGEQME
DLDGEAM
//
