UniProt: J9VV68

Database: UniProt
Entry: J9VV68_CRYNH

LinkDB:  J9VV68_CRYNH 
Original site:  J9VV68_CRYNH

All links

Ontology (7)   
   GO (7)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (13)   
   InterPro (7)   
   Pfam (4)   
   PROSITE (1)   
   SMART (1)   
Literature (1)   
   PubMed (1)   
All databases (25)   

Download RDF

ID   J9VV68_CRYNH            Unreviewed;      1684 AA.
AC   J9VV68;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
GN   ORFNames=CNAG_04904 {ECO:0000313|EMBL:AFR97311.1};
OS   Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS   CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR97311.1, ECO:0000313|Proteomes:UP000010091};
RN   [1] {ECO:0000313|EMBL:AFR97311.1, ECO:0000313|Proteomes:UP000010091}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC   {ECO:0000313|Proteomes:UP000010091};
RX   PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA   Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA   Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA   Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA   Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA   Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA   Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA   Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA   Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA   Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA   Cuomo C.A., Dietrich F.S.;
RT   "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT   grubii reveals complex RNA expression and microevolution leading to
RT   virulence attenuation.";
RL   PLoS Genet. 10:E1004261-E1004261(2014).
CC   -!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
CC       coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC       {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC       {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC       {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
CC       {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC       {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC       {ECO:0000256|PIRNR:PIRNR002290}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004287}.
CC   -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC       {ECO:0000256|ARBA:ARBA00009535, ECO:0000256|PIRNR:PIRNR002290}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP003829; AFR97311.1; -; Genomic_DNA.
DR   RefSeq; XP_012052289.1; XM_012196899.1.
DR   SwissPalm; J9VV68; -.
DR   GeneID; 23888279; -.
DR   KEGG; cng:CNAG_04904; -.
DR   VEuPathDB; FungiDB:CNAG_04904; -.
DR   HOGENOM; CLU_002136_0_0_1; -.
DR   OrthoDB; 5474327at2759; -.
DR   Proteomes; UP000010091; Chromosome 10.
DR   GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR   GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR   GO; GO:0071439; C:clathrin complex; IEA:InterPro.
DR   GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   Gene3D; 1.25.40.730; -; 1.
DR   Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR   InterPro; IPR015348; Clathrin_H-chain_linker_core.
DR   InterPro; IPR016025; Clathrin_H-chain_N.
DR   InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
DR   InterPro; IPR016341; Clathrin_heavy_chain.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR10292:SF1; CLATHRIN HEAVY CHAIN; 1.
DR   PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR   Pfam; PF00637; Clathrin; 7.
DR   Pfam; PF09268; Clathrin-link; 1.
DR   Pfam; PF13838; Clathrin_H_link; 1.
DR   Pfam; PF01394; Clathrin_propel; 2.
DR   PIRSF; PIRSF002290; Clathrin_H_chain; 1.
DR   SMART; SM00299; CLH; 7.
DR   SUPFAM; SSF48371; ARM repeat; 6.
DR   SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR   PROSITE; PS50236; CHCR; 7.
PE   3: Inferred from homology;
KW   Coated pit {ECO:0000256|ARBA:ARBA00023176, ECO:0000256|PIRNR:PIRNR002290};
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW   ECO:0000256|PIRNR:PIRNR002290};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002290};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          342..365
FT                   /note="Clathrin heavy chain linker core motif"
FT                   /evidence="ECO:0000259|Pfam:PF09268"
SQ   SEQUENCE   1684 AA;  190067 MW;  0562ACB14278DD08 CRC64;
     MAAPEKPIVF TEHLQLTALG IQPTSISFQT LTLESDAWIC VRETGDTPQV VIVNLNDAGD
     VVRRPITADS AIMNPRANEK ILALKAGRQL QVFNLGAKAK LGTHLMNDDV TFWTWINDTT
     LGIVTEREVY HWKVMDGQAA PTKVFDRHAN LTANQIINYR ISHDEKWLVL VGISSNPNAG
     QPGENGFKIK GAMQLYSIER GVSQPIEGHA ATFASIKLDG APNPTKLFAF AVRTAAGAKL
     HIVEIGHQAP NPPFQKKAVD VFFPAEALND FPVSLQISQK HGILYLVTKF GFIHLYEIET
     GQCIYMNRIS GETIFTTAEY ETLSGIIGVN RKGQVLSVSV DEQTVVPYIQ QTLNNPELAI
     KLATRAGLPG ADGMIQQQYQ VYIQNGQYGE AAKVAANSPR GLLRTPQTIE TLKNLPAVPG
     TLTPILQYFG ILLEKGELNK YESLELARPV VQQGKKQLLE KWLKENKLES SEELGDLCRM
     ADMNLALSVY LRANVPNKVV ACFAELGQFD KIVLYSKKVG YTPDYAQLLQ HLVRINPDKG
     AEFATQLVND ENGPLVDLDR IVDIFMSQNM LQQATSILLD ALKDNKPEQG PLQTRLLEMN
     LMSAPQVADA ILGNEMFTHY DRPRIANLAE KAGLVQRALE HYEDINDIKR VVVHTNLFKP
     EWLVDYFGRL TVEQSFACLQ EMLRTNLRQN LPIVVQIATK YSDLLGSVKL IELFEQFKSS
     DGLYYYLGSI VNLSEDPEVH FKYIQAATRT GQIREVERIC RESNFYNPEK VKNFLKEARL
     DDQLPLIIVC DRFDFVHDLV LYLYQNGLTN FIEIYVQRVN SARTPQVIGG LLDVDCDETT
     VKNLLMSVTG TFPIDDLVDE VEKRNRLKLI LPWLNNKVEQ GSTDHAVYNA IAKISIDSNN
     NPEKFLKENN LYDPAIVGKY CEKRDPYLAY IAYAKGFCDD ELINITNENQ MYKHQARYLV
     KRRDVDLWTQ VLNPESIHRR ALIDQIIATA IPESVDPDDV SVTVKAFMHM ELHGPLLELL
     EKIIIEPSPF SDNRSLQSLM FLTAIKNDKG KVMGYINRLS GYDVETIAKV ATEAGLYEEA
     FTIYQKHDMH AEAMSVLVEH MASIDRGFAY ANKINEPAVW SRLGKAQLDG LRVKEAIDSY
     IKADDPSNFE EVIEIANRAG KHDDLVRYLQ MARKTAREPK IDTELAYAYA KTDRLHDMEE
     FLGMTNVADV LQVGEKCFDD ELYQAAKLLF SSISNWARLA TTLIYLGENQ VAVDAARKAG
     NTQVWKQVNA ACVDKKEFRL AQICGLNLVV HAEELPALLS LYERNGYFDE IISLMEAGLG
     LERAHMGMFT ELSVLYAKYR PEKLMEHLKL FWQRVNIPKV IKAAEQAHLW PELVFLYIVY
     DEPDNASLAM MERLADWDHD QFKKVIVKVA NMEIAYRAVS FYLARQPTLL PDLLAALTPR
     LDHSRVIKIL QTEDHLPLAK PYLIATQKLN LAVINEAYND LLIEEEDHIT LRSSLETYDE
     YDAIKLAKRL EKHELLEFRR IAALLYRLNS LWEESISLSK ADRLWRDALE TAAASKDIAV
     CEELAGYFVS IGNKDAFAAI LYVCFEFVRA DFVEEMSWRF GLSDYSMPYK LQQQRDQATK
     IAALEKEVKE LRTKTAEKEP DNEPSSLMGS GLGGRLMIGG PSGGPPFMGS MPNGGMMAQP
     TGFY
//

DBGET integrated database retrieval system