ID J9VW93_CRYNH Unreviewed; 435 AA.
AC J9VW93;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 22-FEB-2023, entry version 46.
DE SubName: Full=HIV Tat-specific factor 1 {ECO:0000313|EMBL:AFR95955.2};
GN ORFNames=CNAG_06670 {ECO:0000313|EMBL:AFR95955.2};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR95955.2, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR95955.2, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
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DR EMBL; CP003826; AFR95955.2; -; Genomic_DNA.
DR RefSeq; XP_012050312.1; XM_012194922.1.
DR AlphaFoldDB; J9VW93; -.
DR GeneID; 23889849; -.
DR KEGG; cng:CNAG_06670; -.
DR VEuPathDB; FungiDB:CNAG_06670; -.
DR HOGENOM; CLU_026945_0_2_1; -.
DR OrthoDB; 10213at2759; -.
DR Proteomes; UP000010091; Chromosome 7.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd12285; RRM3_RBM39_like; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR InterPro; IPR034393; TatSF1-like.
DR PANTHER; PTHR15608:SF0; HIV TAT-SPECIFIC FACTOR 1; 1.
DR PANTHER; PTHR15608; SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2; 1.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00360; RRM; 2.
DR SMART; SM00361; RRM_1; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50102; RRM; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 150..238
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 92..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..124
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..290
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 435 AA; 48920 MW; D2E0E57FAB61C0D0 CRC64;
MALTPSRNRI NRTIVCSLQI LSGLYIYAPL FGRMPSNAPI PGQFEQDTRV SFDKVSGKWQ
YEDDEGTEHE WNGTAWIPII DDELVRAQQA AYSVPGVDES TPSNAAIARE ERRNKKRKKG
EKDYTSNTSN APATADTSRP APAPSAPKKT GVWVTNLPPN TTVQKLADVF SKAGVLHIDD
EGNPRIKMYY DDEGNFKGEA WVVYFKEGSV DLAITLLDDT ELELGAGYPP MRVKVAEYFK
DQDKGKDKEK KEKIEGEKKR LTAEEKQKMS KRMKTLQSKI TWRSDDESDD PAAPLGGAPA
PTNNRFARVV VLKGMFVLEE LEKDPALLLE LKEEVREEAA TLGQVTSVIL YDKEEDGVMT
IKFKEPVSAQ ACVAKMNNRY FDGRVIYAGL YNGKERFKKS GGRTFDEDND EEEKERLDNF
AHWLVEGEDE EAAKK
//
