ID J9VYB0_CRYNH Unreviewed; 214 AA.
AC J9VYB0;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Protein YAE1 {ECO:0000256|ARBA:ARBA00018400};
DE AltName: Full=Protein yae1 {ECO:0000256|ARBA:ARBA00017286};
GN ORFNames=CNAG_04581 {ECO:0000313|EMBL:AFR97634.1};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR97634.1, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR97634.1, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the YAE1 family.
CC {ECO:0000256|ARBA:ARBA00007096}.
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DR EMBL; CP003829; AFR97634.1; -; Genomic_DNA.
DR RefSeq; XP_012052073.1; XM_012196683.1.
DR AlphaFoldDB; J9VYB0; -.
DR GeneID; 23887974; -.
DR KEGG; cng:CNAG_04581; -.
DR VEuPathDB; FungiDB:CNAG_04581; -.
DR HOGENOM; CLU_091047_0_0_1; -.
DR OrthoDB; 2018411at2759; -.
DR Proteomes; UP000010091; Chromosome 10.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR019191; Essential_protein_Yae1_N.
DR InterPro; IPR038881; Yae1-like.
DR PANTHER; PTHR18829; PROTEIN YAE1 HOMOLOG; 1.
DR PANTHER; PTHR18829:SF0; PROTEIN YAE1 HOMOLOG; 1.
DR Pfam; PF09811; Yae1_N; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 36..74
FT /note="Essential protein Yae1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF09811"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 137..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 214 AA; 23669 MW; B3463A108C75EE89 CRC64;
MFEDDDWLNA PQQGGSRDPL VEQEYTRIAS KYSDAGYREG ITDGKLSTLQ QGFDEAFAQS
VSLSRRMGAL RGRAAALLAF AKASSSSSSP TSVPILNSIS HSQQALLDDL HDYIKRLSSI
RRSEVLPEDL ERIAHEREDH AAASASTSNG VFELDTTDER EMESLEKSLE MFGSASGTEA
NQDDEKEGEE KKYGEEGIQR LEAKLKELEG RFRG
//
