ID J9YZT2_9PROT Unreviewed; 590 AA.
AC J9YZT2;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Peptidoglycan glycosyltransferase {ECO:0000313|EMBL:AFS49068.1};
DE EC=2.4.1.129 {ECO:0000313|EMBL:AFS49068.1};
GN ORFNames=HIMB59_00008740 {ECO:0000313|EMBL:AFS49068.1};
OS alpha proteobacterium HIMB59.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Candidatus Pelagibacterales;
OC Candidatus Pelagibacteraceae.
OX NCBI_TaxID=744985 {ECO:0000313|EMBL:AFS49068.1, ECO:0000313|Proteomes:UP000006097};
RN [1] {ECO:0000313|EMBL:AFS49068.1, ECO:0000313|Proteomes:UP000006097}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HIMB59 {ECO:0000313|EMBL:AFS49068.1,
RC ECO:0000313|Proteomes:UP000006097};
RA Grote J., Thrash C., Huggett M.J., Landry Z., Carini P., Giovannoni S.J.,
RA Rappe M.S., Brinkac L., Kim M., Beeson K., Ferriera S., Sutton G.,
RA Friedman R., Venter J.C.;
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP003801; AFS49068.1; -; Genomic_DNA.
DR AlphaFoldDB; J9YZT2; -.
DR STRING; 744985.HIMB59_00008740; -.
DR KEGG; apc:HIMB59_00008740; -.
DR PATRIC; fig|744985.3.peg.872; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_1_2_5; -.
DR OrthoDB; 9766847at2; -.
DR Proteomes; UP000006097; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000313|EMBL:AFS49068.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006097};
KW Transferase {ECO:0000313|EMBL:AFS49068.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 61..219
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 252..582
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 590 AA; 66465 MW; BF6F93DA0F258111 CRC64;
MEKNKASQDS IKILNRRSFI ITTIGLILSL IVSIRLFSLQ ILNFNFYQKK SVENKVAVKA
TPPLRGDIFD NEKNLVAANA SLYEFVIYKN LNKNYMDEVS NLNKLINLDL KISNISEKLK
SFNAYTPFIL SRANWQQIVE FEKNKFLFTS IKIIESKKRY YPHKNLSQII GYMGQSSDDK
YLYPKGVFHL EKTYDELLKG KPGKIFNEVN SRGKVIREIS IEEPIKGNSL ELTINLKLQN
YAQSVLPLSN KGSIVVINRF DGSILSMNSN PTYDAQVFED RDNETINSLL NDPEKPLLNR
AFTGFYPPGS VFKPIPALLG LKKNMINEKT EVFCSGSTSL ADRNYYCWKK GGHGKVNLKK
AIKESCDCYF YELAKKINID DLSELATNLG LNNTYKIGLS NAQKGLIPNK KWKKSNLEQG
WYQGETLITS IGQGYNLTSP LQLATLYSAL LNGGRFPSPK LIKNEPSKYL GEELNSNHQK
AILNALKAAV QEPSGTAYKL NLDNPNFVKI GGKTGTSQVV RIKEEDREDD LYKTKEIEDK
FKDHSVFVGY APIDEPKYIA SVIIENGGSG SAVAAPIAHN VLNFAYQENV
//
