GenomeNet

Database: UniProt
Entry: J9YZZ3_9PROT
LinkDB: J9YZZ3_9PROT
Original site: J9YZZ3_9PROT 
ID   J9YZZ3_9PROT            Unreviewed;       455 AA.
AC   J9YZZ3;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-SEP-2017, entry version 36.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=HIMB59_00004920 {ECO:0000313|EMBL:AFS48692.1};
OS   alpha proteobacterium HIMB59.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Pelagibacterales;
OC   Pelagibacteraceae.
OX   NCBI_TaxID=744985 {ECO:0000313|EMBL:AFS48692.1, ECO:0000313|Proteomes:UP000006097};
RN   [1] {ECO:0000313|EMBL:AFS48692.1, ECO:0000313|Proteomes:UP000006097}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HIMB59 {ECO:0000313|EMBL:AFS48692.1,
RC   ECO:0000313|Proteomes:UP000006097};
RA   Grote J., Thrash C., Huggett M.J., Landry Z., Carini P.,
RA   Giovannoni S.J., Rappe M.S., Brinkac L., Kim M., Beeson K.,
RA   Ferriera S., Sutton G., Friedman R., Venter J.C.;
RL   Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP003801; AFS48692.1; -; Genomic_DNA.
DR   EnsemblBacteria; AFS48692; AFS48692; HIMB59_00004920.
DR   KEGG; apc:HIMB59_00004920; -.
DR   PATRIC; fig|744985.3.peg.490; -.
DR   KO; K02313; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000006097; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006097};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006097}.
FT   DOMAIN      151    279       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      362    431       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     159    166       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   455 AA;  52263 MW;  0F8C6CCADF57F47F CRC64;
     MTDDIDQEVN VSWSSITSEL KKSLDKDTFQ NWIKPIQFES LLDTSLTLSV PTRFLRDWII
     KNYASVIKRA YLDQDITIHK LSILVKENNN RVIPGTEVVH QEKEEDGDDH YYDDISAPLD
     PQFTFDNFIV GKPNELAYAA AQRVAQSEVV SFNPLFLYGG VGLGKTHLMH AVAWNIKKRN
     PKKNVVYLTA EKFMYQFIKA LRFKNIMSFK EQFRSVDVLM IDDVQFIIGK DNTQEEFFHT
     FNTLVDKKRQ IIISADKSPA DLEGLEDRLK SRLGWGLVAD IHPLTYELRY GIIEAKAEQK
     NIKLTSDVLE FLANKITNNV REMEGALNRL AVHASLQESE ITVDLVKDVL KDLLRTNSRK
     ITIDEIQKKV VEHYNIKLSD MHSPRRSRSV ARPRQVAMYL AKSITTRSLP EIGRKFGGRD
     HTTVIHAIKT IEEIMVNDPS LAEDIELLTR ILQTS
//
DBGET integrated database retrieval system