ID J9Z358_9TYRA Unreviewed; 222 AA.
AC J9Z358;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Nerve growth factor {ECO:0000313|EMBL:AFS49782.1};
DE Flags: Fragment;
GN Name=NGF {ECO:0000313|EMBL:AFS49782.1};
OS Anairetes reguloides reguloides.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Tyrannidae; Anairetes.
OX NCBI_TaxID=1193129 {ECO:0000313|EMBL:AFS49782.1};
RN [1] {ECO:0000313|EMBL:AFS49782.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22525942; DOI=10.1016/j.ympev.2012.04.002;
RA Dubay S.G., Witt C.C.;
RT "An improved phylogeny of the Andean tit-tyrants (Aves, Tyrannidae): More
RT characters trump sophisticated analyses.";
RL Mol. Phylogenet. Evol. 64:285-296(2012).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783}.
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DR EMBL; JX283691; AFS49782.1; -; Genomic_DNA.
DR AlphaFoldDB; J9Z358; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR020425; Nerve_growth_factor_bsu.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF10; BETA-NERVE GROWTH FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR00268; NGF.
DR PRINTS; PR01913; NGFBETA.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR001789-1}; Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 110..214
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 118..183
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 161..211
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 171..213
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFS49782.1"
FT NON_TER 222
FT /evidence="ECO:0000313|EMBL:AFS49782.1"
SQ SEQUENCE 222 AA; 24634 MW; E4545EEEFC72254C CRC64;
QAAPKSEDNA PLEYPAEHSL LNTHRSNRHH LPEAAPPTPR GQDAAWSRRE AINITVDPKI
FKKRRFRSPR VLFSTEPPPV AGQGQSLGLL GGAGSLNRTA RTKRSTHPVL HRGEFSVCDS
VSMWVGDKTT ATDIKGKEVT VLGEVNINNN VFKQYFFETK CRDPKPVSGG CRGIDAKHWN
SYCTTTHTFV KALTMEGKQA AWRFIRIDTA CVCVLSRKSG RP
//
