ID K0D8Z4_LEUCJ Unreviewed; 323 AA.
AC K0D8Z4;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Lactate dehydrogenase-like 2-hydroxyacid dehydrogenase {ECO:0000313|EMBL:AFT82444.1};
GN OrderedLocusNames=C270_07675 {ECO:0000313|EMBL:AFT82444.1};
OS Leuconostoc carnosum (strain JB16).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Leuconostoc.
OX NCBI_TaxID=1229758 {ECO:0000313|EMBL:AFT82444.1, ECO:0000313|Proteomes:UP000006299};
RN [1] {ECO:0000313|EMBL:AFT82444.1, ECO:0000313|Proteomes:UP000006299}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JB16 {ECO:0000313|EMBL:AFT82444.1,
RC ECO:0000313|Proteomes:UP000006299};
RX PubMed=23144413; DOI=10.1128/JB.01805-12;
RA Jung J.Y., Lee S.H., Jeon C.O.;
RT "Complete genome sequence of Leuconostoc carnosum strain JB16, isolated
RT from Kimchi.";
RL J. Bacteriol. 194:6672-6673(2012).
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC ECO:0000256|RuleBase:RU003719}.
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DR EMBL; CP003851; AFT82444.1; -; Genomic_DNA.
DR RefSeq; WP_014975054.1; NC_018673.1.
DR AlphaFoldDB; K0D8Z4; -.
DR STRING; 1229758.C270_07675; -.
DR GeneID; 61187111; -.
DR KEGG; lcn:C270_07675; -.
DR PATRIC; fig|1229758.3.peg.1540; -.
DR eggNOG; COG1052; Bacteria.
DR HOGENOM; CLU_019796_1_1_9; -.
DR Proteomes; UP000006299; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43026; 2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED; 1.
DR PANTHER; PTHR43026:SF1; 2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000006299}.
FT DOMAIN 5..321
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 113..290
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 323 AA; 36397 MW; C8260A29CC7E7A97 CRC64;
MKILFYNVAD IEKSFINDWA KNNNITVKTL SVAIDSNNIE LTRDYDAVVF YPGEAFLTDE
KLYAQLAQNG MRQISVKSTG YDNINFTFAE KYQLSITNVP NYSPESVAHF TVMSIIMLLR
HMPIYLHKQA TTHRKDFIGQ ELTDLTIGIY GAGRLGSLVA KTLKYMGARV LINSRTSKPE
LEQLGIESVD FKTLLTVSDV ISIHVPLNEQ THHLFDFDNL DLMKQEAMLV NTARGSIIDT
KALIKHLQQG KFKGVALDAL EDEEFFEVTD NPYYQALMAF DNVLVTPHIA YFTQAAVRDI
AITALDNARD IVTNGESENI VLN
//
