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Database: UniProt
Entry: K0ELM9_9NOCA
LinkDB: K0ELM9_9NOCA
Original site: K0ELM9_9NOCA 
ID   K0ELM9_9NOCA            Unreviewed;       664 AA.
AC   K0ELM9;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   05-JUL-2017, entry version 38.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=O3I_000005 {ECO:0000313|EMBL:AFT97963.1};
OS   Nocardia brasiliensis ATCC 700358.
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Nocardia.
OX   NCBI_TaxID=1133849 {ECO:0000313|EMBL:AFT97963.1, ECO:0000313|Proteomes:UP000006304};
RN   [1] {ECO:0000313|EMBL:AFT97963.1, ECO:0000313|Proteomes:UP000006304}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HUJEG-1 {ECO:0000313|EMBL:AFT97963.1};
RX   PubMed=22535940; DOI=10.1128/JB.00210-12;
RA   Vera-Cabrera L., Ortiz-Lopez R., Elizondo-Gonzalez R.,
RA   Perez-Maya A.A., Ocampo-Candiani J.;
RT   "Complete genome sequence of Nocardia brasiliensis HUJEG-1.";
RL   J. Bacteriol. 194:2761-2762(2012).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP003876; AFT97963.1; -; Genomic_DNA.
DR   RefSeq; WP_014980828.1; NC_018681.1.
DR   EnsemblBacteria; AFT97963; AFT97963; O3I_000005.
DR   KEGG; nbr:O3I_000005; -.
DR   KO; K02313; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000006304; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006304};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006304}.
FT   DOMAIN      358    486       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      570    638       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     366    373       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   664 AA;  74071 MW;  DE070ED4E95671DB CRC64;
     MDDEQNVLAT VWPEVVAELT TGSPDGAIPP VTRAQQAWLK LVKPLTVAQG FALLSVPSSL
     AQEAIERDLR EPILRSLARR LGPQVEGLGV RIAAPTAPAA DRAGSNPRHA RMTSRPERAR
     DNGPRDNGPL DNGRRDNGPR ENGHSQPGYP GTDYQGRDEY PAPRYAQPND YAPEYAGGAE
     YTDTEYAPEY PPAAEYDRPD YPRDNYQGQD DYPAHTELPP RREPAPAARR EPGLPPRRES
     IPPGQESLFT PDPGPATMRG PVRAPVREAA PAEDPGLAAA HESVRESDNP RAEHDDEPVV
     NVRNSWPTYF TKSQETSAPA TSSASLNAKY TFETFVIGAS NRFAHAAAVA IAEAPARAYN
     PLFVWGASGL GKTHLLHAAG HYAQRLFPGM RVKYVSTEEF TNDFINSLRD DRKVAFKRRY
     RETDILLVDD IQFIEGKEGI QEEFFHTFNT LHNANKQIVV SSDRPPKQLA TLEERLRTRF
     EWGLITDVQP PELETRIAIL RKKARMDRLD VPHDVLELIA SRVERNIREL EGALIRVTAF
     ASLNGQPLDL PLAEVVLRDL MPDTAALEIN AATIMAVTAE YFNTTLEELT GPGKARPLAQ
     ARQIAMYLCR ELTDLSLPKI GQAFGRDHTT VMYAEKKVRK EMTERRRVYD QVQELTARIK
     QRSR
//
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