ID K0K298_SACES Unreviewed; 1249 AA.
AC K0K298;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Chromosome partition protein Smc {ECO:0000256|HAMAP-Rule:MF_01894};
GN Name=smc {ECO:0000256|HAMAP-Rule:MF_01894,
GN ECO:0000313|EMBL:CCH34375.1};
GN OrderedLocusNames=BN6_71400 {ECO:0000313|EMBL:CCH34375.1};
OS Saccharothrix espanaensis (strain ATCC 51144 / DSM 44229 / JCM 9112 / NBRC
OS 15066 / NRRL 15764).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharothrix.
OX NCBI_TaxID=1179773 {ECO:0000313|EMBL:CCH34375.1, ECO:0000313|Proteomes:UP000006281};
RN [1] {ECO:0000313|EMBL:CCH34375.1, ECO:0000313|Proteomes:UP000006281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51144 / DSM 44229 / JCM 9112 / NBRC 15066 / NRRL 15764
RC {ECO:0000313|Proteomes:UP000006281};
RX PubMed=22958348; DOI=10.1186/1471-2164-13-465;
RA Strobel T., Al-Dilaimi A., Blom J., Gessner A., Kalinowski J.,
RA Luzhetska M., Puhler A., Szczepanowski R., Bechthold A., Ruckert C.;
RT "Complete genome sequence of Saccharothrix espanaensis DSM 44229T and
RT comparison to the other completely sequenced Pseudonocardiaceae.";
RL BMC Genomics 13:465-465(2012).
CC -!- FUNCTION: Required for chromosome condensation and partitioning.
CC {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- DOMAIN: Contains large globular domains required for ATP hydrolysis at
CC each terminus and a third globular domain forming a flexible hinge near
CC the middle of the molecule. These domains are separated by coiled-coil
CC structures. {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC3 subfamily.
CC {ECO:0000256|ARBA:ARBA00005917}.
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DR EMBL; HE804045; CCH34375.1; -; Genomic_DNA.
DR AlphaFoldDB; K0K298; -.
DR STRING; 1179773.BN6_71400; -.
DR KEGG; sesp:BN6_71400; -.
DR PATRIC; fig|1179773.3.peg.7214; -.
DR eggNOG; COG1196; Bacteria.
DR HOGENOM; CLU_001042_2_2_11; -.
DR Proteomes; UP000006281; Chromosome.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030261; P:chromosome condensation; IEA:InterPro.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:InterPro.
DR CDD; cd03278; ABC_SMC_barmotin; 1.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01894; Smc_prok; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR InterPro; IPR011890; SMC_prok.
DR NCBIfam; TIGR02168; SMC_prok_B; 1.
DR PANTHER; PTHR43977; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR PANTHER; PTHR43977:SF1; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_01894};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|HAMAP-
KW Rule:MF_01894};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01894};
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_01894}; Reference proteome {ECO:0000313|Proteomes:UP000006281}.
FT DOMAIN 518..631
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT REGION 1193..1249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 175..209
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 247..283
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 338..383
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 426..495
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 690..773
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 805..839
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT BINDING 40..47
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
SQ SEQUENCE 1249 AA; 136348 MW; 3C4E2DB12459A55B CRC64;
MVLGYAAPVH LKSLTLKGFK SFASATTLRF EPGITCVVGP NGSGKSNVLD ALRWVMGTQG
AKDLRGGKME DVIFAGTSGR APLGRAEVTL TIDNSDGVLP IEYTEVSITR RMFREGATEY
EINGSSCRLM DIQELLSDSG IGREMHVIVG QGQLAAILES KPEERRAFVE EAAGVLKHRK
RKEKALRKLE AMQANLARLT DLTAELRRQL KPLGKQAEIA RRAQAVQSEL RDARMRLLAD
DLVTRRAALA REEQDEATAR ARRTEVEQSL QQAQFQQNEL EDQVSADAPK LQQAQDTWYR
LSALEERLRG TVRLAVERER HLSASVEAPR GGRDPDELDA EAEQTAELEQ ELQDAVTEAR
IGLAEAVETR AELERVVQAA EKAHVAAVRA IADRREGLAR LSGQVEALRS KTSATAEEIE
RMSVALAEAA ERAEVVAQEL AEAREVTGTE DEDDVGLDER HQRAVEANDA ARSRVEELVK
AERTAERDIA SWQARVDALS LGLTRKDGAG ALLASRLPGL LGSVAALLTV EPGFEVALAA
ALGPVADAVA VASGADALAA LELLKEQDAG RAGVLVGGSV PVDLPSWPVL PQGARWAVEL
VRSPEALRPA LHRALDRLAV VDGLAGARDL VEAYPDVRAV TREGDVFGAD WAVGGSGRSQ
SVIEVQAAVD EASEKLALTE RSLERSAAAL EGARAEQRAR RTEVDALKEQ LNEAKVRRAR
SSERLNRLAA AVRSAQAEVE RVRVQREKVE AAREENLLKL GELEERLLVA EEQPLDDEPD
TAQRDEAAAE LASARQGEVD ARLHLRTAEE RARAVQGRAE GLRRAARAER EARERAQRAH
AARARGAVVA KAVVRGGEVA LARIGESLAR AARDRDVAQE RKAQRETFLT QVRSLVREMS
VELEKLTDAV HRDEVLRAEQ RMRIEQLETK VAEDFGIGLD DLVAEYGPDV FIPPSQQEVA
EYEAAKERGE AVTAPQPIPF DRDTQARRAK RAERDLSLLG KVNPLALEEF AALEERYKFL
SNQLEDIKAT RRDLLTVVKE VDDKILEVFT SAYDDVAREF EVVFKVLFPG GEGRLVLTEP
DDMLTTGIEL EARPPGKKVK RLSLLSGGEK SLAAVAMLVA IFRARPSPFY VMDEVEAALD
DTNLHRLISL FEQLRERSQL LIITHQKPTM EIADALYGVS MRGDGISQVI SQRLRGRDDV
RPAKSAPAAV PPPAEAPAVE TPVAAPAEVP AQEVPAEVVA EPAAGEPED
//
