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Database: UniProt
Entry: K0KC71_WICCF
LinkDB: K0KC71_WICCF
Original site: K0KC71_WICCF 
ID   K0KC71_WICCF            Unreviewed;       821 AA.
AC   K0KC71;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   10-MAY-2017, entry version 20.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=VPH1A {ECO:0000313|EMBL:CCH40496.1};
GN   ORFNames=BN7_29 {ECO:0000313|EMBL:CCH40496.1};
OS   Wickerhamomyces ciferrii (strain F-60-10 / ATCC 14091 / CBS 111 / JCM
OS   3599 / NBRC 0793 / NRRL Y-1031) (Yeast) (Pichia ciferrii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Phaffomycetaceae; Wickerhamomyces.
OX   NCBI_TaxID=1206466 {ECO:0000313|Proteomes:UP000009328};
RN   [1] {ECO:0000313|EMBL:CCH40496.1, ECO:0000313|Proteomes:UP000009328}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F-60-10 / ATCC 14091 / CBS 111 / JCM 3599 / NBRC 0793 / NRRL
RC   Y-1031 {ECO:0000313|Proteomes:UP000009328};
RX   PubMed=23193139; DOI=10.1128/EC.00258-12;
RA   Schneider J., Andrea H., Blom J., Jaenicke S., Rueckert C.,
RA   Schorsch C., Szczepanowski R., Farwick M., Goesmann A., Puehler A.,
RA   Schaffer S., Tauch A., Koehler T., Brinkrolf K.;
RT   "Draft genome sequence of Wickerhamomyces ciferrii NRRL Y-1031 F-60-
RT   10.";
RL   Eukaryot. Cell 11:1582-1583(2012).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CCH40496.1}.
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DR   EMBL; CAIF01000001; CCH40496.1; -; Genomic_DNA.
DR   EnsemblFungi; CCH40496; CCH40496; BN7_29.
DR   InParanoid; K0KC71; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000009328; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009328};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Hydrolase {ECO:0000313|EMBL:CCH40496.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009328};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    410    433       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    454    472       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    531    552       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    564    586       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    625    643       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    724    743       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    755    776       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      101    135       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   821 AA;  93819 MW;  B3338D18C43E5628 CRC64;
     MSEEAIFRSA DVSLVQLYIP SEISREAVYA LGEADTIQFR DLNSKVNTFQ RSFVNEIRRL
     TNVERQYNYF KEQLNHRGVP LKPAPYIEDQ EFTPAAKPSD IDEKVESAQL LEERLSQLVD
     ASENLETRKK DLLQSRHVLK AANQFFNKEA EHVQRQSFDL IDTDDHDIEQ QQQNQNAAIS
     ENYVTGVIPT EKANILEKIL WRVLRGNLIL ETVQIEDPIY DPKSKQYINK SVFIVFSHGH
     DIISRIKKIS ESLDADLYEV DTEENKRSES LLEVNGSLED LNTVLETTNR TLNTELIAIA
     QELSSWAAVI LKEKSVYQTL NLFDYDPNRK VLIAEGWVPT NEIPSLKETL DSTSTDVSSV
     VNILQTTKTP PTYHKTNKFT AAFQSIVDAY GIAEYKEVNP GLPTIVTFPF MFAIMFGDMG
     HGFILSLAAL FLVSHEKQFA RIKRDEIFDM AFTGRYILLL MGLFSIFTGF LYNDLFSKSM
     TIFNSGWKWP EHHEGETIFA EQTSVYPIGL DPAWHGTENA LLFTNSYKMK LSILMGFIHM
     TYSYFFSLVN HLHFKSVIDI IGNFIPGLLF MQSIFGYLSI CIVYKWSIDW ISLGKPAPGL
     LNMLISMFLS PGTVEEYLYP HQEKVQVFLL IIALICVPWL LLLKPLYFKY KIDQEHKYQE
     LNADPEAVQD LPRNPEELQA MEHDDDDEEG EEGHNFGDIM IHQVIHTIEF CLNSVSHTAS
     YLRLWALSLA HAQLSTVLWS MTIQNAFGAT GITGVIMTVF LFGMWFVLTV VILVIMEGTS
     AMLHSLRLHW VESMSKFFVG GGKIYTPFSF KSILAEQGDL E
//
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