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Database: UniProt
Entry: K0KDE5_SACES
LinkDB: K0KDE5_SACES
Original site: K0KDE5_SACES 
ID   K0KDE5_SACES            Unreviewed;       565 AA.
AC   K0KDE5;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   24-JAN-2024, entry version 49.
DE   RecName: Full=L-glutamate gamma-semialdehyde dehydrogenase {ECO:0000256|ARBA:ARBA00012884};
DE            EC=1.2.1.88 {ECO:0000256|ARBA:ARBA00012884};
DE   AltName: Full=L-glutamate gamma-semialdehyde dehydrogenase {ECO:0000256|ARBA:ARBA00032259};
GN   OrderedLocusNames=BN6_75890 {ECO:0000313|EMBL:CCH34814.1};
OS   Saccharothrix espanaensis (strain ATCC 51144 / DSM 44229 / JCM 9112 / NBRC
OS   15066 / NRRL 15764).
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Saccharothrix.
OX   NCBI_TaxID=1179773 {ECO:0000313|EMBL:CCH34814.1, ECO:0000313|Proteomes:UP000006281};
RN   [1] {ECO:0000313|EMBL:CCH34814.1, ECO:0000313|Proteomes:UP000006281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51144 / DSM 44229 / JCM 9112 / NBRC 15066 / NRRL 15764
RC   {ECO:0000313|Proteomes:UP000006281};
RX   PubMed=22958348; DOI=10.1186/1471-2164-13-465;
RA   Strobel T., Al-Dilaimi A., Blom J., Gessner A., Kalinowski J.,
RA   Luzhetska M., Puhler A., Szczepanowski R., Bechthold A., Ruckert C.;
RT   "Complete genome sequence of Saccharothrix espanaensis DSM 44229T and
RT   comparison to the other completely sequenced Pseudonocardiaceae.";
RL   BMC Genomics 13:465-465(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-
CC         glutamate + NADH; Xref=Rhea:RHEA:30235, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58066; EC=1.2.1.88;
CC         Evidence={ECO:0000256|ARBA:ARBA00001468};
CC   -!- PATHWAY: Amino-acid degradation; L-proline degradation into L-
CC       glutamate; L-glutamate from L-proline: step 2/2.
CC       {ECO:0000256|ARBA:ARBA00004786}.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986}.
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DR   EMBL; HE804045; CCH34814.1; -; Genomic_DNA.
DR   AlphaFoldDB; K0KDE5; -.
DR   STRING; 1179773.BN6_75890; -.
DR   KEGG; sesp:BN6_75890; -.
DR   PATRIC; fig|1179773.3.peg.7660; -.
DR   eggNOG; COG1012; Bacteria.
DR   HOGENOM; CLU_005391_4_1_11; -.
DR   OMA; KYRTYPR; -.
DR   UniPathway; UPA00261; UER00374.
DR   Proteomes; UP000006281; Chromosome.
DR   GO; GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0010133; P:proline catabolic process to glutamate; IEA:UniProtKB-UniPathway.
DR   CDD; cd07123; ALDH_F4-17_P5CDH; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR005931; P5CDH/ALDH4A1.
DR   NCBIfam; TIGR01236; D1pyr5carbox1; 1.
DR   PANTHER; PTHR42862; DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR42862:SF1; DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:CCH34814.1};
KW   Proline metabolism {ECO:0000256|ARBA:ARBA00023062};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006281}.
FT   DOMAIN          75..535
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   REGION          20..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   565 AA;  60824 MW;  7E62EB3D5324EDCC CRC64;
     MPVTFATAAH RTTACHDDHM DAVTSVPDPA NEPVRGYAPG SPERESLQRR VAELEGERHE
     LTQTIDGVRR MAGGDPVDVV QPHDHRHVLG VTGNATHEDV ADAVRAARRA APGWRELPFD
     ARAAILLKAA DLLAGPWRDT LNAATVLGQS KSAQQAEIDA ACELIDFLRF NVHFARRLLA
     EQPESSPGVW NRFDHRALDG FVVAITPFNF TAIAGNLPLA PALMGNTVVW KPSVTQQLAA
     HHTMLLLEEA GLPPGVINLV TGDGRAVSAV AMTDPHFAGL HFTGSTNTFK ALWRTMSDNL
     DTYRSYPRIV GETGGKDFVV AHPSADPAAL VTGLVRGAFE YQGQKCSAAS RAYVARSVWT
     GIRDELADVT NSLTYGDVRD FANFGGAVID ARAFAKHKAA LEAAHAESGI EVLAGGTCDD
     EVGYFVRPTV LVGTDPTNEV FTTEYFGPIL SVHVYEDDRF DDVLELVDQS SPYALTGAVF
     ATDRAAVERA GRALRFAAGN FYVNDKPTGA VVGQQPFGGA RASGTNDKAG SIFNLQRWIS
     PRSIKETFVP PTDHRYPHMG AATPE
//
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