ID K0KDE5_SACES Unreviewed; 565 AA.
AC K0KDE5;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=L-glutamate gamma-semialdehyde dehydrogenase {ECO:0000256|ARBA:ARBA00012884};
DE EC=1.2.1.88 {ECO:0000256|ARBA:ARBA00012884};
DE AltName: Full=L-glutamate gamma-semialdehyde dehydrogenase {ECO:0000256|ARBA:ARBA00032259};
GN OrderedLocusNames=BN6_75890 {ECO:0000313|EMBL:CCH34814.1};
OS Saccharothrix espanaensis (strain ATCC 51144 / DSM 44229 / JCM 9112 / NBRC
OS 15066 / NRRL 15764).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharothrix.
OX NCBI_TaxID=1179773 {ECO:0000313|EMBL:CCH34814.1, ECO:0000313|Proteomes:UP000006281};
RN [1] {ECO:0000313|EMBL:CCH34814.1, ECO:0000313|Proteomes:UP000006281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51144 / DSM 44229 / JCM 9112 / NBRC 15066 / NRRL 15764
RC {ECO:0000313|Proteomes:UP000006281};
RX PubMed=22958348; DOI=10.1186/1471-2164-13-465;
RA Strobel T., Al-Dilaimi A., Blom J., Gessner A., Kalinowski J.,
RA Luzhetska M., Puhler A., Szczepanowski R., Bechthold A., Ruckert C.;
RT "Complete genome sequence of Saccharothrix espanaensis DSM 44229T and
RT comparison to the other completely sequenced Pseudonocardiaceae.";
RL BMC Genomics 13:465-465(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-
CC glutamate + NADH; Xref=Rhea:RHEA:30235, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945, ChEBI:CHEBI:58066; EC=1.2.1.88;
CC Evidence={ECO:0000256|ARBA:ARBA00001468};
CC -!- PATHWAY: Amino-acid degradation; L-proline degradation into L-
CC glutamate; L-glutamate from L-proline: step 2/2.
CC {ECO:0000256|ARBA:ARBA00004786}.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986}.
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DR EMBL; HE804045; CCH34814.1; -; Genomic_DNA.
DR AlphaFoldDB; K0KDE5; -.
DR STRING; 1179773.BN6_75890; -.
DR KEGG; sesp:BN6_75890; -.
DR PATRIC; fig|1179773.3.peg.7660; -.
DR eggNOG; COG1012; Bacteria.
DR HOGENOM; CLU_005391_4_1_11; -.
DR OMA; KYRTYPR; -.
DR UniPathway; UPA00261; UER00374.
DR Proteomes; UP000006281; Chromosome.
DR GO; GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0010133; P:proline catabolic process to glutamate; IEA:UniProtKB-UniPathway.
DR CDD; cd07123; ALDH_F4-17_P5CDH; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR005931; P5CDH/ALDH4A1.
DR NCBIfam; TIGR01236; D1pyr5carbox1; 1.
DR PANTHER; PTHR42862; DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR42862:SF1; DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:CCH34814.1};
KW Proline metabolism {ECO:0000256|ARBA:ARBA00023062};
KW Reference proteome {ECO:0000313|Proteomes:UP000006281}.
FT DOMAIN 75..535
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT REGION 20..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 565 AA; 60824 MW; 7E62EB3D5324EDCC CRC64;
MPVTFATAAH RTTACHDDHM DAVTSVPDPA NEPVRGYAPG SPERESLQRR VAELEGERHE
LTQTIDGVRR MAGGDPVDVV QPHDHRHVLG VTGNATHEDV ADAVRAARRA APGWRELPFD
ARAAILLKAA DLLAGPWRDT LNAATVLGQS KSAQQAEIDA ACELIDFLRF NVHFARRLLA
EQPESSPGVW NRFDHRALDG FVVAITPFNF TAIAGNLPLA PALMGNTVVW KPSVTQQLAA
HHTMLLLEEA GLPPGVINLV TGDGRAVSAV AMTDPHFAGL HFTGSTNTFK ALWRTMSDNL
DTYRSYPRIV GETGGKDFVV AHPSADPAAL VTGLVRGAFE YQGQKCSAAS RAYVARSVWT
GIRDELADVT NSLTYGDVRD FANFGGAVID ARAFAKHKAA LEAAHAESGI EVLAGGTCDD
EVGYFVRPTV LVGTDPTNEV FTTEYFGPIL SVHVYEDDRF DDVLELVDQS SPYALTGAVF
ATDRAAVERA GRALRFAAGN FYVNDKPTGA VVGQQPFGGA RASGTNDKAG SIFNLQRWIS
PRSIKETFVP PTDHRYPHMG AATPE
//