ID   K0KDT0_SACES            Unreviewed;       681 AA.
AC   K0KDT0;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   RecName: Full=Peptidase C14 caspase domain-containing protein {ECO:0000259|Pfam:PF00656};
GN   OrderedLocusNames=BN6_77190 {ECO:0000313|EMBL:CCH34939.1};
OS   Saccharothrix espanaensis (strain ATCC 51144 / DSM 44229 / JCM 9112 / NBRC
OS   15066 / NRRL 15764).
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Saccharothrix.
OX   NCBI_TaxID=1179773 {ECO:0000313|EMBL:CCH34939.1, ECO:0000313|Proteomes:UP000006281};
RN   [1] {ECO:0000313|EMBL:CCH34939.1, ECO:0000313|Proteomes:UP000006281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51144 / DSM 44229 / JCM 9112 / NBRC 15066 / NRRL 15764
RC   {ECO:0000313|Proteomes:UP000006281};
RX   PubMed=22958348; DOI=10.1186/1471-2164-13-465;
RA   Strobel T., Al-Dilaimi A., Blom J., Gessner A., Kalinowski J.,
RA   Luzhetska M., Puhler A., Szczepanowski R., Bechthold A., Ruckert C.;
RT   "Complete genome sequence of Saccharothrix espanaensis DSM 44229T and
RT   comparison to the other completely sequenced Pseudonocardiaceae.";
RL   BMC Genomics 13:465-465(2012).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
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DR   EMBL; HE804045; CCH34939.1; -; Genomic_DNA.
DR   RefSeq; WP_015105048.1; NC_019673.1.
DR   AlphaFoldDB; K0KDT0; -.
DR   STRING; 1179773.BN6_77190; -.
DR   KEGG; sesp:BN6_77190; -.
DR   PATRIC; fig|1179773.3.peg.7795; -.
DR   eggNOG; COG2319; Bacteria.
DR   eggNOG; COG4249; Bacteria.
DR   HOGENOM; CLU_403795_0_0_11; -.
DR   OrthoDB; 491589at2; -.
DR   BioCyc; SESP1179773:BN6_RS42755-MONOMER; -.
DR   Proteomes; UP000006281; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1460; -; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR011600; Pept_C14_caspase.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR44129:SF1; PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB SUBUNIT BETA; 1.
DR   PANTHER; PTHR44129; WD REPEAT-CONTAINING PROTEIN POP1; 1.
DR   Pfam; PF00656; Peptidase_C14; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 3.
DR   SUPFAM; SSF52129; Caspase-like; 1.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006281};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   TRANSMEM        626..644
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        650..671
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          2..234
FT                   /note="Peptidase C14 caspase"
FT                   /evidence="ECO:0000259|Pfam:PF00656"
FT   REPEAT          573..597
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ   SEQUENCE   681 AA;  73555 MW;  880748303EAF71A9 CRC64;
     MRTALIVATD TYADPTFGAL RAPQHDAAEL DRVLADPAIG AFSTELLVNT PFQRIRERID
     EVFSRAGSDD LVLLYLSGHG VKDRTGKLHF AAGDTRRDLL PSTSVPAQFV REMIDHSPAR
     KVVVWLDCCY GGAFPSGMLP RAAGSVDVVE QLDEGRGCAV MTASTHIQYA YEPDGVVRGE
     TEPSVFTKAI IEGLRTGAAD ADGDGEITAQ ELYDFVYRWV RRESPDQTPT RSGTVSGDLR
     IAYAGTPLPA GLPDEVRYLL RSNDPTLRSA GVRILVERAA TDPIAEAALA VLTRNGSAEV
     AEAAQAPVVP APPIVRKAVP DEGLVLRHGA ALDGSATHVA FSPVDPVLAT SDAIWDTTTW
     QRKTSLPPGI KHLAFSADGR LLAVDRSGGI EILSTWDWEV LVRIHRPARA GRLAFGHDGR
     TLLWWRPGGQ VWTWTREDDQ WLMSVDLGPE DVRAVAVSSG KPLAVLLTDR HELRLWDLEH
     RTPVGEGRRV DSGVRDVALS PDGTLIATLS TRRPELRRAS DLQGVRAFDM TGHVLGSVGF
     SPSGRTLAIS GMTGVHLWDV ASGELRQVLP VGVKALAFSP DDRFAVGTSP DRRIRLWTTG
     PDLPDNLRVQ PPASTPEEQW RIDRRILLAL TLALVAGVAA AVLVRSVLVL SWWADGLTGL
     AVAGGVGRVF WPVKKRVPSG G
//