ID K0KJR6_WICCF Unreviewed; 829 AA.
AC K0KJR6;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Membrane protein {ECO:0000313|EMBL:CCH41338.1};
GN ORFNames=BN7_877 {ECO:0000313|EMBL:CCH41338.1};
OS Wickerhamomyces ciferrii (strain ATCC 14091 / BCRC 22168 / CBS 111 / JCM
OS 3599 / NBRC 0793 / NRRL Y-1031 F-60-10) (Yeast) (Pichia ciferrii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Wickerhamomyces.
OX NCBI_TaxID=1206466 {ECO:0000313|EMBL:CCH41338.1, ECO:0000313|Proteomes:UP000009328};
RN [1] {ECO:0000313|EMBL:CCH41338.1, ECO:0000313|Proteomes:UP000009328}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14091 / BCRC 22168 / CBS 111 / JCM 3599 / NBRC 0793 / NRRL
RC Y-1031 F-60-10 {ECO:0000313|Proteomes:UP000009328};
RX PubMed=23193139; DOI=10.1128/EC.00258-12;
RA Schneider J., Andrea H., Blom J., Jaenicke S., Ruckert C., Schorsch C.,
RA Szczepanowski R., Farwick M., Goesmann A., Puhler A., Schaffer S.,
RA Tauch A., Kohler T., Brinkrolf K.;
RT "Draft genome sequence of Wickerhamomyces ciferrii NRRL Y-1031 F-60-10.";
RL Eukaryot. Cell 11:1582-1583(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCH41338.1}.
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DR EMBL; CAIF01000017; CCH41338.1; -; Genomic_DNA.
DR AlphaFoldDB; K0KJR6; -.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_002458_0_2_1; -.
DR InParanoid; K0KJR6; -.
DR Proteomes; UP000009328; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF83; CALCIUM PERMEABLE STRESS-GATED CATION CHANNEL 1; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009328};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 20..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 461..487
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 508..532
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 601..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 627..643
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 664..684
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 690..710
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..176
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 228..402
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 416..683
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 741..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..760
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..780
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 829 AA; 95394 MW; FE68D490321CEA30 CRC64;
MSALPPDLDP TKQPQRVFKA QLIVCTTFGF LAFFTFCVLR YRWPHIYAVR VLRKKDIRNL
PKTLFGWCLA LYKITDEEVL EHGGLDAYVF LGFFRMAIKY FALCSLISFF IIGPIRYYYT
GHFDSDGISW DSVVSDTINM AFDDKHPLDP KQYKAAWVYT VFTYVFTWLA FYFLWQQTEK
VVKVRQKYLG QQNSVTDRTI LLEGLPTELN PNDYSSSTDL VSQDTQKFDE ESLKTYIEDL
GIGKVREIYI SYNWDNLREL FKKRKQILRN LEVSYAKYCP LKVEVYTYGN LEPSVSPVKN
LPHTEAQPLV EDRPRPQLRL GFAGIFGEKV DAIEYFSDQL VEIDKQIQFE REKNNFKQAR
SAFVTMDSVA SAQMAAQAVL DPHVHRLIAR LAPAPHDVCW DNISISKSTK FFKANLITII
IGISTVGLIF PVVSLSTLIN LKTIEKFWPA LGELISKSEL AILIIGLIPP YIYTLLNVTI
PYFYSFLSTQ QGYLSNGEVE LSTLSKNFFY IFFNLFLVFT LAGTASNVWA LLGDTTKIAF
ELANSLKTLS LFYVDLILLQ GLGLFPFKLL QIGDVGLEII SKLFYAKTAR DYRTLYYTPP
VFDFGIILPQ HILILIITMI YSVTSTKIVT AGLVYYVLGY YTYKYQLLYT MVHPQHSTGQ
AWPMIFRRIC LGLVLFQITM AGTLALEHAF LLSILIVPLI IMTLFVAYTF EKDYLPLSFF
IALKAIKKPN SQTIDEIHAT SSGWQQTNSS TPLLEAESQQ QKQTRLKKRR STIDETREET
QTYRCPYLTD PLDGPIIGFD GDYIQQIQYE PTSMHERVIR KYHSVSEWE
//
