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Database: UniProt
Entry: K0KRW8_WICCF
LinkDB: K0KRW8_WICCF
Original site: K0KRW8_WICCF 
ID   K0KRW8_WICCF            Unreviewed;       815 AA.
AC   K0KRW8;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   02-NOV-2016, entry version 19.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=VPH1B {ECO:0000313|EMBL:CCH44074.1};
GN   ORFNames=BN7_3633 {ECO:0000313|EMBL:CCH44074.1};
OS   Wickerhamomyces ciferrii (strain F-60-10 / ATCC 14091 / CBS 111 / JCM
OS   3599 / NBRC 0793 / NRRL Y-1031) (Yeast) (Pichia ciferrii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Phaffomycetaceae; Wickerhamomyces.
OX   NCBI_TaxID=1206466 {ECO:0000313|Proteomes:UP000009328};
RN   [1] {ECO:0000313|EMBL:CCH44074.1, ECO:0000313|Proteomes:UP000009328}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F-60-10 / ATCC 14091 / CBS 111 / JCM 3599 / NBRC 0793 / NRRL
RC   Y-1031 {ECO:0000313|Proteomes:UP000009328};
RX   PubMed=23193139; DOI=10.1128/EC.00258-12;
RA   Schneider J., Andrea H., Blom J., Jaenicke S., Rueckert C.,
RA   Schorsch C., Szczepanowski R., Farwick M., Goesmann A., Puehler A.,
RA   Schaffer S., Tauch A., Koehler T., Brinkrolf K.;
RT   "Draft genome sequence of Wickerhamomyces ciferrii NRRL Y-1031 F-60-
RT   10.";
RL   Eukaryot. Cell 11:1582-1583(2012).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CCH44074.1}.
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DR   EMBL; CAIF01000108; CCH44074.1; -; Genomic_DNA.
DR   EnsemblFungi; CCH44074; CCH44074; BN7_3633.
DR   InParanoid; K0KRW8; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000009328; Unassembled WGS sequence.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005770; C:late endosome; IEA:EnsemblFungi.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:EnsemblFungi.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:EnsemblFungi.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0007035; P:vacuolar acidification; IEA:EnsemblFungi.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009328};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Hydrolase {ECO:0000313|EMBL:CCH44074.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009328};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    400    424       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    445    462       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    522    542       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    554    575       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    615    634       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    715    738       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    750    770       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       80    114       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   815 AA;  92816 MW;  F3C2409ED730E785 CRC64;
     MSFIQLYIPT EVSRDVITTL GEIGNVQFND LNQNVSAFQR TFVQEIRKFD EVERQLRYLT
     SVIEKEHGLL IAHNPTLTIA QNSISSIENL ITDVANLENR VQQLDSSYEE LKHREHKLLE
     YRHVLNSSRT FFDNNIEGQA RISIDRVDDA PLLLEQESLE AGYQLSNLNE LALNYVVGSI
     PRSKVEILNK ILWRTLRGNL YFNHVELEEK ILDIRSGNEV EKDVFIVFTH GELLLQKVER
     IIDSLDGNVY DVSSDLDIHE QSIQQVNAQL TDVSHVLTNT HQTLHTELYV IADQLQIWQA
     IIRREKLVYV TLNKFKSANR GLISEGWVPS TEIDQVKNAL RDVEGAESAV LTIVHTNKTP
     PTYHRTNKFT QAFQSIVDAY GIASYQEVNP GLATIVTFPF MFAIMFGDLG HGFIVLLAAL
     TLVLNEKKLA LKKKDEIFDM AYNGRYIILL MGLFSIYTGL LYNDVFSKSM TLFRSGWKYP
     EDFKLHDTVE GTKTGVYPFG LDWAWHGAEN NLIFTNSYKM KLSILMGFIH MSYSFFFSLV
     NYRHRHSKVD IIGNFIPGLI FMQSIFGYLS LAIVYKWSRD WIKLEKPAPG LLNMLINMFL
     APGVIDAELY PGQSFVQVIL VLAAAVCVPW LLLYKPMTLR RQNNSAIEAG YHNLHDLSHN
     DTLADTEEHA GDDFLVEDFE EPEEFNFGDI MIHQVIHTIE FCLNCVSHTA SYLRLWALSL
     AHAQLSSVLW SMTIANAFSS EAPGSPSSVA KVVLLFGMWF VLTVCILVLM EGTSAMLHSL
     RLHWVEAMSK FFEGEGYAYE PFTLKDIGEE PATAT
//
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