GenomeNet

Database: UniProt
Entry: K0P6H4_9BACT
LinkDB: K0P6H4_9BACT
Original site: K0P6H4_9BACT 
ID   K0P6H4_9BACT            Unreviewed;       463 AA.
AC   K0P6H4;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   25-OCT-2017, entry version 39.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:CCM10438.1};
GN   ORFNames=CAHE_0661 {ECO:0000313|EMBL:CCM10438.1};
OS   Cardinium endosymbiont cEper1 of Encarsia pergandiella.
OC   Bacteria; Bacteroidetes; Cytophagia; Cytophagales; Amoebophilaceae;
OC   Candidatus Cardinium.
OX   NCBI_TaxID=1231626 {ECO:0000313|EMBL:CCM10438.1, ECO:0000313|Proteomes:UP000003996};
RN   [1] {ECO:0000313|EMBL:CCM10438.1, ECO:0000313|Proteomes:UP000003996}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CEper1 {ECO:0000313|EMBL:CCM10438.1};
RX   PubMed=23133394; DOI=10.1371/journal.pgen.1003012;
RA   Penz T., Schmitz-Esser S., Kelly S.E., Cass B.N., Muller A., Woyke T.,
RA   Malfatti S.A., Hunter M.S., Horn M.;
RT   "Comparative Genomics Suggests an Independent Origin of Cytoplasmic
RT   Incompatibility in Cardinium hertigii.";
RL   PLoS Genet. 8:e1003012-e1003012(2012).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; HE983995; CCM10438.1; -; Genomic_DNA.
DR   RefSeq; WP_014934805.1; NC_018605.1.
DR   EnsemblBacteria; CCM10438; CCM10438; CAHE_0661.
DR   KEGG; che:CAHE_0661; -.
DR   PATRIC; fig|1231626.3.peg.645; -.
DR   KO; K02313; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000003996; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000003996};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003996}.
FT   DOMAIN      156    286       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      368    437       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     164    171       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   463 AA;  52021 MW;  EB09FEC289AC729D CRC64;
     MHTDSKIIWD KCLLYIQGQI SAQTYKTWFS PIIAKDFKDG ILTIQVPSQF FYEWLEEHHL
     PLLKQAVRQE IGPHGKLAYA VVIDKGNKKQ KPLMVHLPTY PGPTPKGTIT KLPTISENEI
     FRLNPNYIFN NLIEGSCNQL AKSAAQAVAK QPGGTAFNPL TLYGGIGLGK THISQAIGNE
     VKTFFPDKKV AYVSSEKFTT QFIEALRNNH VQVFTGQYLT VDLLILDDIQ FLAGKEKTQE
     IFFHIFNHLH QLKKQIIITS DCAPRDLKGL QERLLSRFKW GLTADLQCPD FETRVAIIHS
     KMAADGITLS SDLIDYIAKH VDTNVRELEG VLISLIAHAS LTKRDINLAL AQQVLKDIVA
     QQPTAETTIE VIQEQVVAHY TISLDALKGK SRKKELVMAR QTAMHLIKKY TTHSLKTIGA
     YFGGRDHTTV IHAVEVIDDL LDKDPQYAQV YGSLENKIKA TLK
//
DBGET integrated database retrieval system