ID K0R248_THAOC Unreviewed; 1109 AA.
AC K0R248;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Guanylate cyclase domain-containing protein {ECO:0000259|PROSITE:PS50125};
GN ORFNames=THAOC_36251 {ECO:0000313|EMBL:EJK45144.1};
OS Thalassiosira oceanica (Marine diatom).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC Coscinodiscophyceae; Thalassiosirophycidae; Thalassiosirales;
OC Thalassiosiraceae; Thalassiosira.
OX NCBI_TaxID=159749 {ECO:0000313|EMBL:EJK45144.1, ECO:0000313|Proteomes:UP000266841};
RN [1] {ECO:0000313|EMBL:EJK45144.1, ECO:0000313|Proteomes:UP000266841}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1005 {ECO:0000313|EMBL:EJK45144.1,
RC ECO:0000313|Proteomes:UP000266841};
RX PubMed=22835381; DOI=10.1186/gb-2012-13-7-r66;
RA Lommer M., Specht M., Roy A.S., Kraemer L., Andreson R., Gutowska M.A.,
RA Wolf J., Bergner S.V., Schilhabel M.B., Klostermeier U.C., Beiko R.G.,
RA Rosenstiel P., Hippler M., Laroche J.;
RT "Genome and low-iron response of an oceanic diatom adapted to chronic iron
RT limitation.";
RL Genome Biol. 13:R66-R66(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJK45144.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGNL01048734; EJK45144.1; -; Genomic_DNA.
DR AlphaFoldDB; K0R248; -.
DR EnsemblProtists; EJK45144; EJK45144; THAOC_36251.
DR eggNOG; KOG0618; Eukaryota.
DR Proteomes; UP000266841; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 2.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR44103; PROPROTEIN CONVERTASE P; 1.
DR PANTHER; PTHR44103:SF1; PROPROTEIN CONVERTASE P; 1.
DR Pfam; PF13517; FG-GAP_3; 3.
DR Pfam; PF00211; Guanylate_cyc; 2.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 2.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000266841};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 606..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 653..786
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 788..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1038..1109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..844
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1052..1075
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1077..1091
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1092..1109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1109 AA; 118961 MW; 14D876067AB9CE3D CRC64;
MDAEAETLLF DDVDGSSAAG DASNEREAAD VGSLAEPIAP EGETGPARTP DTTSPLVLAQ
ADAEASLLTS AIRAVVTNQA MGARCAVAAD FDSDGRMDLV SASSNDNAVS WYKNLGNDST
SGRPTFSIKK PISWSSNGSR IVTVADIDQD GHIDVIGASY YDNSLRWFRN VPQIYNNEDD
PNDPKNGSVE GIKFEENLIS DAVNEGQGVT VADLDNDGDP DIITASSGDN TIAVFKNIDK
GTFCEIKEVV DSNAKGARTV VAADLNGDGL LDLASASKDD DTVAWYPNTM RNVVNHSTGA
THRVGGYFDP SVKNVISNGT ESTGAYSLVA ADVDLDGDQD LVVASNGNDH VSLWRNDGKG
NFEKTLIYDN ADFVLSVTAL DIDRDGDIDV ASASFYDGHI NWYENVDGQG YEWKNHTVYV
GIQGHYVSHG DMDGDGDEDL IAAMHAENTV SVYFAQTPCD DSAISGKISR PECCHEGSQW
DADTGRCLPC KVGFYGVGSG LAAECVACPT NACTVGDSEN SNSNLLPATC SGIAGCADPV
ESIAQCSCGV DQFRDNDYDV CALCPQGQIR PDLGISRPMN TLGNYSLWED MQGTCRIKPA
TVVSPLPLYI IIPVSVIVAL LIFVMIYVIY RMNQTIKYRT RDVNNAPTTG LVGLLFTDVE
GSTALWDEDK TTMSAALDIH HDVIRKVIDR YSAYEVKTIG DSFMIAVKCP DTGAEEGNKG
SCDKLLHLAN DIQQDLLHAE WPVELANMPT ACTEFTNVNR FEKNGDRVEP KLTFRGLRVR
IGVHVGVHSD RLSKTPSSAP SSASPGGDEL SASGNRRQPA SLRRSSLSSK SSQNSSTNDE
DVGDTLDSIS YLAGSDATGV KDTGGKHEVQ VKYDVITKGY DYYGPATNCA ARVESLAFGG
QTLMSEEVSS RLSDECKKEC LIQTVGGVTV KGVTDEVFLY SVMPRSLSGR SFRGVYRRRE
SDGGSILTDE DSIFRRGSHS VVSIDLSGQR KSPKDDAAMT SDVSSMTPVQ LMTAVLRLRN
KCRNLEYALE ETHYQQSKRS LAVGVPVDRG ESTNLTEGTT PENSGSDSTP PQDDIVKNIS
DLDDLSDRSA STPHRRGSAV SFANDLSVS
//
