ID K0UE69_MYCFO Unreviewed; 227 AA.
AC K0UE69;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase {ECO:0000313|EMBL:EJZ05542.1};
DE EC=2.1.1.14 {ECO:0000313|EMBL:EJZ05542.1};
DE Flags: Fragment;
GN ORFNames=MFORT_29569 {ECO:0000313|EMBL:EJZ05542.1};
OS Mycolicibacterium fortuitum subsp. fortuitum DSM 46621 = ATCC 6841 = JCM
OS 6387.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1214102 {ECO:0000313|EMBL:EJZ05542.1, ECO:0000313|Proteomes:UP000006043};
RN [1] {ECO:0000313|EMBL:EJZ05542.1, ECO:0000313|Proteomes:UP000006043}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM46621 {ECO:0000313|Proteomes:UP000006043};
RX PubMed=23105073; DOI=10.1128/JB.01461-12;
RA Ho Y.S., Adroub S.A., Aleisa F., Mahmood H., Othoum G., Rashid F.,
RA Zaher M., Ali S., Bitter W., Pain A., Abdallah A.M.;
RT "Complete Genome Sequence of Mycobacterium fortuitum subsp. fortuitum Type
RT Strain DSM46621.";
RL J. Bacteriol. 194:6337-6338(2012).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the vitamin-B12 independent methionine synthase
CC family. {ECO:0000256|ARBA:ARBA00009553}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJZ05542.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ALQB01000221; EJZ05542.1; -; Genomic_DNA.
DR AlphaFoldDB; K0UE69; -.
DR PATRIC; fig|1214102.3.peg.5783; -.
DR HOGENOM; CLU_040013_1_0_11; -.
DR Proteomes; UP000006043; Unassembled WGS sequence.
DR GO; GO:0003871; F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd03311; CIMS_C_terminal_like; 1.
DR Gene3D; 3.20.20.210; -; 1.
DR InterPro; IPR002629; Met_Synth_C/arc.
DR InterPro; IPR038071; UROD/MetE-like_sf.
DR PANTHER; PTHR30519; 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE; 1.
DR PANTHER; PTHR30519:SF0; 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE; 1.
DR Pfam; PF01717; Meth_synt_2; 1.
DR SUPFAM; SSF51726; UROD/MetE-like; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000313|EMBL:EJZ05542.1};
KW Transferase {ECO:0000313|EMBL:EJZ05542.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 2..222
FT /note="Cobalamin-independent methionine synthase MetE C-
FT terminal/archaeal"
FT /evidence="ECO:0000259|Pfam:PF01717"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EJZ05542.1"
SQ SEQUENCE 227 AA; 24501 MW; FF19A203AC00B431 CRC64;
ARPKPMTVEW ITYAQSLTDK PVKGMLTGPV TILAWSFVRD DQPLADTAAQ VALAIRDETV
DLQSAGIAII QVDEPALREL LPLRSKDKEA YLNWAVDAFR LSTSGVDDST QIHTHLCYSE
FGEVIGAIAD LDADVTSIEA ARSHMEVLGD LNAVGFSNSV GPGVYDIHSP RIPGVEEIAM
SLREALRAVP AERLWVNPDC GLKTRTTAEV TESLKHLVAA AAEVRGA
//
