ID K0UQ41_MYCFO Unreviewed; 423 AA.
AC K0UQ41;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=GTP cyclohydrolase II {ECO:0008006|Google:ProtNLM};
GN ORFNames=MFORT_23502 {ECO:0000313|EMBL:EJZ08921.1};
OS Mycolicibacterium fortuitum subsp. fortuitum DSM 46621 = ATCC 6841 = JCM
OS 6387.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1214102 {ECO:0000313|EMBL:EJZ08921.1, ECO:0000313|Proteomes:UP000006043};
RN [1] {ECO:0000313|EMBL:EJZ08921.1, ECO:0000313|Proteomes:UP000006043}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM46621 {ECO:0000313|Proteomes:UP000006043};
RX PubMed=23105073; DOI=10.1128/JB.01461-12;
RA Ho Y.S., Adroub S.A., Aleisa F., Mahmood H., Othoum G., Rashid F.,
RA Zaher M., Ali S., Bitter W., Pain A., Abdallah A.M.;
RT "Complete Genome Sequence of Mycobacterium fortuitum subsp. fortuitum Type
RT Strain DSM46621.";
RL J. Bacteriol. 194:6337-6338(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJZ08921.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ALQB01000123; EJZ08921.1; -; Genomic_DNA.
DR RefSeq; WP_003884823.1; NZ_JH814755.1.
DR AlphaFoldDB; K0UQ41; -.
DR PATRIC; fig|1214102.3.peg.4638; -.
DR HOGENOM; CLU_029639_0_0_11; -.
DR UniPathway; UPA00275; -.
DR Proteomes; UP000006043; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003935; F:GTP cyclohydrolase II activity; IEA:InterPro.
DR GO; GO:0009231; P:riboflavin biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00641; GTP_cyclohydro2; 1.
DR Gene3D; 3.40.50.10990; GTP cyclohydrolase II; 1.
DR InterPro; IPR022163; GTP_CH_N.
DR InterPro; IPR032677; GTP_cyclohydro_II.
DR InterPro; IPR000926; RibA.
DR InterPro; IPR036144; RibA-like_sf.
DR PANTHER; PTHR47259; -; 1.
DR PANTHER; PTHR47259:SF2; URACIL-REGULATED PROTEIN 1; 1.
DR Pfam; PF12471; GTP_CH_N; 1.
DR Pfam; PF00925; GTP_cyclohydro2; 1.
DR SUPFAM; SSF142695; RibA-like; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 17..203
FT /note="GTP cyclohydrolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12471"
FT DOMAIN 244..379
FT /note="GTP cyclohydrolase II"
FT /evidence="ECO:0000259|Pfam:PF00925"
SQ SEQUENCE 423 AA; 45003 MW; D3670F310E6ED77B CRC64;
MVADSGGASV EPAKARHIRL TSHSAVAGTP TIRWGAASAA ERGPVIGTTT TRAHRNVIGT
HSGSYSVYRA LAVAAGTLSP GHRADLTNTA PTDVIGPYAQ WSQPEAIVSL DPWGAMISEA
FTTELAAGYD IRPTIAVTKA HVLVPEITTA IAAGRLHPDG AVLLENGAAL VTKAAIEPVW
FLPGVAARFG CTETALRRVL FEETGGMYPE LVTRGDLEVF LPPIGGQTVY IFGAPRDLAD
PTVELTARVH DECNGSDVFG SDICTCRPYL THAIEECIAG AQRGGVGMVA YSRKEGRALG
EVTKFLVYNA RKRQDGGDTA DQYFARTECV AGVQDMRFQE LMPDVLHWLG IRKIHRLVSM
SNMKYDAITG SGIEVGQRVN IPDELIPDDA RVEIDAKMAA GYFTPGPVPG ADELKIAKGR
GLA
//
