ID   K0UTB3_MYCVA            Unreviewed;       718 AA.
AC   K0UTB3;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=THIF-type NAD/FAD binding fold domain-containing protein {ECO:0000259|Pfam:PF00899};
GN   ORFNames=MVAC_10927 {ECO:0000313|EMBL:EJZ09996.1};
OS   Mycolicibacterium vaccae ATCC 25954.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=1194972 {ECO:0000313|EMBL:EJZ09996.1, ECO:0000313|Proteomes:UP000006072};
RN   [1] {ECO:0000313|EMBL:EJZ09996.1, ECO:0000313|Proteomes:UP000006072}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25954 {ECO:0000313|EMBL:EJZ09996.1,
RC   ECO:0000313|Proteomes:UP000006072};
RX   PubMed=23105074; DOI=10.1128/JB.01462-12;
RA   Ho Y.S., Adroub S.A., Abadi M., Al Alwan B., Alkhateeb R., Gao G.,
RA   Ragab A., Ali S., van Soolingen D., Bitter W., Pain A., Abdallah A.M.;
RT   "Complete Genome Sequence of Mycobacterium vaccae Type Strain ATCC 25954.";
RL   J. Bacteriol. 194:6339-6340(2012).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJZ09996.1}.
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DR   EMBL; ALQA01000018; EJZ09996.1; -; Genomic_DNA.
DR   RefSeq; WP_003928834.1; NZ_JH814684.1.
DR   AlphaFoldDB; K0UTB3; -.
DR   PATRIC; fig|1194972.3.peg.2189; -.
DR   eggNOG; COG0476; Bacteria.
DR   HOGENOM; CLU_020676_0_0_11; -.
DR   Proteomes; UP000006072; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR   CDD; cd01483; E1_enzyme_family; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.40.109.10; NADH Oxidase; 1.
DR   InterPro; IPR000415; Nitroreductase-like.
DR   InterPro; IPR045886; ThiF/MoeB/HesA.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   PANTHER; PTHR43267; TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE; 1.
DR   PANTHER; PTHR43267:SF1; TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE; 1.
DR   Pfam; PF00899; ThiF; 1.
DR   SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
DR   SUPFAM; SSF55469; FMN-dependent nitroreductase-like; 1.
PE   4: Predicted;
FT   DOMAIN          95..293
FT                   /note="THIF-type NAD/FAD binding fold"
FT                   /evidence="ECO:0000259|Pfam:PF00899"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          345..368
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   718 AA;  76948 MW;  621DACCBF5C5AFA5 CRC64;
     MSFEHSRAHP DDAAGATVLD PADPTDRETL RSLREDPAIT FVDRSTEQAK TLAGLLPAPP
     PELTDEPRRW AYYPWRRTVV GVLGPRGYAR VRSDRNRNLI TAQEQEVLGA LRIGVVGLSV
     GHAVAHTLAM QGMCGEVRLA DFDELELSNL NRVPATVFDI GENKAHIAAR RIAEVDPYIT
     VRVVESGLTP DTITEFLDGL DIVVEECDSL DVKALVREAA RRRRQPVLMA TSDRGLIDVE
     RFDLEPDRPI FHGLLGDVDA AMLAGLDSRE KIPHVLRLVD GANLSARGAA SLVEVGQSLS
     TWPQLVGDVL VGAAAVAEAI RRIGLGEPLS SGRVRIDTAA ALDGLTDPLH LPSPPQEEPA
     PPGAEPDADV RDAVHAVALA ANHAPSGGNV QPWSIETARD AVTIRLDPQY QSTIDVGLRG
     SAVAVGAAAF NARVAAAAHQ RLGAVTFRED GPAPLTAVIE LTEGTDDALA ALYPALSARE
     TNRRHGTPSA LDATVMDALR TAAEREGSRL KLIADRDVLS GIAALLADTD RIRYLTPRLH
     TDMASELRWP GDDLPDFGID VRSLELGAAE LGTLDILRRP DVMALLNAWD AGAVLGADTR
     ARIAGCSALA LVMTDDPSLT GYARGGSASE AVWIAAQQHG LAVQPISPVF LYARHRDELD
     ELSPRFATEL GDLQSRFRHL TAEQPGEVTA LILRLTSAPP ASVRSRRRPV TFADAPVF
//