ID K0UWW4_MYCVA Unreviewed; 382 AA.
AC K0UWW4;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Rieske-type oxygenase {ECO:0000256|ARBA:ARBA00030944};
GN ORFNames=MVAC_04917 {ECO:0000313|EMBL:EJZ11622.1};
OS Mycolicibacterium vaccae ATCC 25954.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1194972 {ECO:0000313|EMBL:EJZ11622.1, ECO:0000313|Proteomes:UP000006072};
RN [1] {ECO:0000313|EMBL:EJZ11622.1, ECO:0000313|Proteomes:UP000006072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25954 {ECO:0000313|EMBL:EJZ11622.1,
RC ECO:0000313|Proteomes:UP000006072};
RX PubMed=23105074; DOI=10.1128/JB.01462-12;
RA Ho Y.S., Adroub S.A., Abadi M., Al Alwan B., Alkhateeb R., Gao G.,
RA Ragab A., Ali S., van Soolingen D., Bitter W., Pain A., Abdallah A.M.;
RT "Complete Genome Sequence of Mycobacterium vaccae Type Strain ATCC 25954.";
RL J. Bacteriol. 194:6339-6340(2012).
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Evidence={ECO:0000256|ARBA:ARBA00001962};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJZ11622.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ALQA01000007; EJZ11622.1; -; Genomic_DNA.
DR RefSeq; WP_003930524.1; NZ_JH814690.1.
DR AlphaFoldDB; K0UWW4; -.
DR PATRIC; fig|1194972.3.peg.995; -.
DR eggNOG; COG4638; Bacteria.
DR HOGENOM; CLU_037178_1_0_11; -.
DR Proteomes; UP000006072; Unassembled WGS sequence.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:InterPro.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProt.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:UniProt.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd03531; Rieske_RO_Alpha_KSH; 1.
DR Gene3D; 2.102.10.10; Rieske [2Fe-2S] iron-sulphur domain; 1.
DR InterPro; IPR045605; KshA-like_C.
DR InterPro; IPR017941; Rieske_2Fe-2S.
DR InterPro; IPR036922; Rieske_2Fe-2S_sf.
DR PANTHER; PTHR21266:SF61; 3-KETOSTEROID-9-ALPHA-MONOOXYGENASE, OXYGENASE COMPONENT; 1.
DR PANTHER; PTHR21266; IRON-SULFUR DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF19298; KshA_C; 1.
DR Pfam; PF00355; Rieske; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF50022; ISP domain; 1.
DR PROSITE; PS51296; RIESKE; 1.
PE 4: Predicted;
KW 2Fe-2S {ECO:0000256|ARBA:ARBA00022714};
KW Dioxygenase {ECO:0000313|EMBL:EJZ11622.1};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221}.
FT DOMAIN 26..128
FT /note="Rieske"
FT /evidence="ECO:0000259|PROSITE:PS51296"
SQ SEQUENCE 382 AA; 43253 MW; 6B5A368F77B4F5D6 CRC64;
MSDTGAVGAV RHIDTGRQMT RFARGWHCLG LAESFRDGQP HGVDAFGTLL VVFADSQGEL
RVLDGYCRHM GGNLAQGTVK GDEVACPFHD WRWGGDGKCK LVPYAKRTPR LARTRAWHTT
EVNGQLLVWH DPEGSTPSAE LTPPTIEGFD EGRWSPWQWN SILIDGAHCR EIVDNNVDMA
HFFYIHHAYP TYFKNVIEGH TASQFMESKP RPDVVADPDK LWEGTYLRSE ATYFGPAYMI
NWLHNDLAPG FTVEVALINC HYPVTHNSFT LQWGVAVREM PELPAAKAAG LAAALNRSFG
EGFLEDVEIW KNKSPIENPL LTEEDGPVYQ HRRWYHQFYV DAADVTADMT DRYEQEVDTT
HAYDLWQQEV EQNLAARRHA TP
//
