ID K0UZ54_MYCVA Unreviewed; 442 AA.
AC K0UZ54;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=TetR family transcriptional regulator {ECO:0000313|EMBL:EJZ07888.1};
GN ORFNames=MVAC_17063 {ECO:0000313|EMBL:EJZ07888.1};
OS Mycolicibacterium vaccae ATCC 25954.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1194972 {ECO:0000313|EMBL:EJZ07888.1, ECO:0000313|Proteomes:UP000006072};
RN [1] {ECO:0000313|EMBL:EJZ07888.1, ECO:0000313|Proteomes:UP000006072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25954 {ECO:0000313|EMBL:EJZ07888.1,
RC ECO:0000313|Proteomes:UP000006072};
RX PubMed=23105074; DOI=10.1128/JB.01462-12;
RA Ho Y.S., Adroub S.A., Abadi M., Al Alwan B., Alkhateeb R., Gao G.,
RA Ragab A., Ali S., van Soolingen D., Bitter W., Pain A., Abdallah A.M.;
RT "Complete Genome Sequence of Mycobacterium vaccae Type Strain ATCC 25954.";
RL J. Bacteriol. 194:6339-6340(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJZ07888.1}.
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DR EMBL; ALQA01000037; EJZ07888.1; -; Genomic_DNA.
DR RefSeq; WP_003928620.1; NZ_JH814684.1.
DR AlphaFoldDB; K0UZ54; -.
DR PATRIC; fig|1194972.3.peg.3405; -.
DR eggNOG; COG1309; Bacteria.
DR HOGENOM; CLU_646932_0_0_11; -.
DR Proteomes; UP000006072; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProt.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR PANTHER; PTHR30055; HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR; 1.
DR PANTHER; PTHR30055:SF226; HTH-TYPE TRANSCRIPTIONAL REPRESSOR RV1474C; 1.
DR Pfam; PF00440; TetR_N; 2.
DR PRINTS; PR00455; HTHTETR.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR PROSITE; PS50977; HTH_TETR_2; 2.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00335};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 35..94
FT /note="HTH tetR-type"
FT /evidence="ECO:0000259|PROSITE:PS50977"
FT DOMAIN 257..317
FT /note="HTH tetR-type"
FT /evidence="ECO:0000259|PROSITE:PS50977"
FT DNA_BIND 57..76
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
FT DNA_BIND 280..299
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 442 AA; 48063 MW; 031A2CACEA37815D CRC64;
MAGDATGQSP RRSRRAGGAK LTPVTAAADA PATDLTRRAE ILKTANTVIA ATGLRSSVQQ
IADAAGILAG SLYHHFESKE AILVELIRLY HADLDRIGDD ALRRLDGPDP GPVADQIIAL
GRAIAGCAVE HRAALQMSFY ESPSSDPELL ELTSRPPTKI QAAMLQALRA GRWSGDIRPD
VDLPTLADRL CQSMLHVGLD VIRHKARTDE LATLKCRIAL EGLASEAPAD ADLDRSDAFA
AAESVIRSWV DDEDQTDLKA AHLRAVARAE FGRRGYEMTT IRDIASAAGL GTGTVYRIIG
SKDELLMSIM LDFGRKVGGA WSEIVHTDST TLEKLDALSW LNINALDQFP DEFRIQLAWM
RQSPPDSTNP TWSFTTRIRQ MKALLSDGIR AGEIQVHSPT ADMLARCIIG EQWIPENILQ
EIGTRNALIL ARDTVLRGVA VR
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