ID K0V408_MYCFO Unreviewed; 1097 AA.
AC K0V408;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Transcriptional activator domain-containing protein {ECO:0000313|EMBL:EJZ14062.1};
GN ORFNames=MFORT_11646 {ECO:0000313|EMBL:EJZ14062.1};
OS Mycolicibacterium fortuitum subsp. fortuitum DSM 46621 = ATCC 6841 = JCM
OS 6387.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1214102 {ECO:0000313|EMBL:EJZ14062.1, ECO:0000313|Proteomes:UP000006043};
RN [1] {ECO:0000313|EMBL:EJZ14062.1, ECO:0000313|Proteomes:UP000006043}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM46621 {ECO:0000313|Proteomes:UP000006043};
RX PubMed=23105073; DOI=10.1128/JB.01461-12;
RA Ho Y.S., Adroub S.A., Aleisa F., Mahmood H., Othoum G., Rashid F.,
RA Zaher M., Ali S., Bitter W., Pain A., Abdallah A.M.;
RT "Complete Genome Sequence of Mycobacterium fortuitum subsp. fortuitum Type
RT Strain DSM46621.";
RL J. Bacteriol. 194:6337-6338(2012).
CC -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC {ECO:0000256|ARBA:ARBA00005820}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJZ14062.1}.
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DR EMBL; ALQB01000039; EJZ14062.1; -; Genomic_DNA.
DR AlphaFoldDB; K0V408; -.
DR PATRIC; fig|1214102.3.peg.2321; -.
DR HOGENOM; CLU_006850_5_0_11; -.
DR Proteomes; UP000006043; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15831; BTAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR005158; BTAD.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR PANTHER; PTHR16305:SF35; TRANSCRIPTIONAL ACTIVATOR DOMAIN; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF03704; BTAD; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM01043; BTAD; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU01091};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 1..93
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT DNA_BIND 1..93
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
SQ SEQUENCE 1097 AA; 117052 MW; F3A702CBCE05BBF5 CRC64;
MLGPVAAWVG DDPVDLGARL QRALLARLVA AHGHTVSVDR LIDDLWEGEP PPKALSALQV
YVSHLRRGLE PGRQRRAPAR ILVSAAPGYC LRLPVDAVDS WQFEAKVTAA YQESDPQQRV
CLLDEALAGW SGDPFAGAGD ALWAAPEIAR LTELRLAAVE AQAAAQVELG RYGTAVAALD
RHVGERPERE GAAAVLATAL YQSGRQSDAL EVLRRTRGHL VDELGLEPGR ALRDLERDIL
RQADHLEPSR PPQPVIPEVV APDRIQANAY GRAEELAEID AAASAVTTSG SAVLWIAGEA
GSGKTTLAGA ATARLRAAGW RTVLGRCPEV HGAPAGWAWT EVLRDLLESG GAQDDARQAL
APLLHDVAGA EAGTFWLGHA VADVLSEVAQ RQPLAVVLDD LHRTDGLTLE LLRLVADRIK
DLPVLVIGTY RPSEDRGELE VARAALTVHT AAHLILDGLD AAATAALAAD YGLTAASGEA
LRLLRERTGG NPLFVRELAR LMAAEGTDAV WASVPVGVRD VLRRRLARLP GPTVTALRQA
AVLGRDIDVD LLAELGRNDP DDLLDALEPA VLLGLLDEPE PGRLRFAHSL VRDTLYEDTS
KLRRSRLHGA ALELLRAPGR SVDAAALAHH AVASATAETA LSAAAFATAA AREADSVGAY
TEAARQWRAA VQMLELAASR RLRPGAESLD HEIDARCGLI SALAQSGDAV AARIELKAAL
QLLTGKSRQD LTVRVLTAWD TPLVWRDREY DESDAQMISL LRQVLAGGPT EVTAAERIRL
LKALYVELEG TDPDGALAAS TELLELARRA YAEDPGSSGR LLCTALNVRA YCALGPDLDA
ERDATAAELL RTAEATEQAD YQAVAHWMLS LAAGHRSDLA TAKRHVDIAV ARAGTGQLVH
LLGVLGLFRA RMYLLAARLE EAVGAYTDLA ARMVENGAAN GAKLAMVGRV TGEFCLGDLG
VLADELVYFY REVSVAALDA AVLALIARGR EAEARELWRD RQPIERAYFW LPFTVLRVNA
AVALGDVEEA EARAADLEPY SGRIAGLGVD GLMVGPVDEA LAAAADALGR PEQARAYREA
ASVLRERLAA EARRFID
//
