ID K0VNK5_MYCVA Unreviewed; 361 AA.
AC K0VNK5;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Pyruvate dehydrogenase {ECO:0000313|EMBL:EJZ12789.1};
GN ORFNames=MVAC_01865 {ECO:0000313|EMBL:EJZ12789.1};
OS Mycolicibacterium vaccae ATCC 25954.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1194972 {ECO:0000313|EMBL:EJZ12789.1, ECO:0000313|Proteomes:UP000006072};
RN [1] {ECO:0000313|EMBL:EJZ12789.1, ECO:0000313|Proteomes:UP000006072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25954 {ECO:0000313|EMBL:EJZ12789.1,
RC ECO:0000313|Proteomes:UP000006072};
RX PubMed=23105074; DOI=10.1128/JB.01462-12;
RA Ho Y.S., Adroub S.A., Abadi M., Al Alwan B., Alkhateeb R., Gao G.,
RA Ragab A., Ali S., van Soolingen D., Bitter W., Pain A., Abdallah A.M.;
RT "Complete Genome Sequence of Mycobacterium vaccae Type Strain ATCC 25954.";
RL J. Bacteriol. 194:6339-6340(2012).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJZ12789.1}.
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DR EMBL; ALQA01000002; EJZ12789.1; -; Genomic_DNA.
DR RefSeq; WP_003928326.1; NZ_JH814683.1.
DR AlphaFoldDB; K0VNK5; -.
DR PATRIC; fig|1194972.3.peg.382; -.
DR eggNOG; COG1071; Bacteria.
DR HOGENOM; CLU_029393_1_0_11; -.
DR Proteomes; UP000006072; Unassembled WGS sequence.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR017596; PdhA/BkdA.
DR InterPro; IPR029061; THDP-binding.
DR NCBIfam; TIGR03181; PDH_E1_alph_x; 1.
DR PANTHER; PTHR43380; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43380:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Pyruvate {ECO:0000313|EMBL:EJZ12789.1}.
FT DOMAIN 43..314
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 361 AA; 39976 MW; 2F128E199B371EB1 CRC64;
MAGRSALSEF GEPIQLVAPD GAPTPEARYR RDLPPETLAW LYECMVLTRE IDTEFVNLQR
QGELALFASC RGQEAAQVGA AACLRKTDWL FPQYRELGAF LLRAIAPAQL GALWRGRWHG
GLGFTDKCVA PVSIPIGTHG LHAVGAAMAA RQLGEDSVTV AFLGDGATSE GDAHEALNLA
AVFRAPCVFF VQNNQWAISV PVERQHAGPT LAHRAIGYGM PGVRVDGNDV LACYAVMEQA
AARAREGGGP TFIEAVTYRM GPHTTSDDPT RYRPAEDVER WRARDPITRY RTYLQRGEVW
TQRLEERIAH RAQRMRSELR DAVINEPDID IVEVFDTVYH DITPDLARQR DELLAELAKE
S
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