ID K0Z5U9_9STRE Unreviewed; 417 AA.
AC K0Z5U9;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG {ECO:0000256|ARBA:ARBA00020461};
DE AltName: Full=Glucose-inhibited division protein A {ECO:0000256|ARBA:ARBA00031800};
DE Flags: Fragment;
GN ORFNames=GMD4S_11917 {ECO:0000313|EMBL:EKA02555.1};
OS Streptococcus sp. GMD4S.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1169673 {ECO:0000313|EMBL:EKA02555.1, ECO:0000313|Proteomes:UP000004724};
RN [1] {ECO:0000313|EMBL:EKA02555.1, ECO:0000313|Proteomes:UP000004724}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GMD4S {ECO:0000313|EMBL:EKA02555.1,
RC ECO:0000313|Proteomes:UP000004724};
RX PubMed=23493677; DOI=10.1101/gr.142208.112;
RA Fitzsimons M.S., Novotny M., Lo C.C., Dichosa A.E., Yee-Greenbaum J.L.,
RA Snook J.P., Gu W., Chertkov O., Davenport K.W., McMurry K., Reitenga K.G.,
RA Daughton A.R., He J., Johnson S.L., Gleasner C.D., Wills P.L.,
RA Parson-Quintana B., Chain P.S., Detter J.C., Lasken R.S., Han C.S.;
RT "Nearly finished genomes produced using gel microdroplet culturing reveal
RT substantial intraspecies genomic diversity within the human microbiome.";
RL Genome Res. 23:878-888(2013).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKA02555.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJRE01000465; EKA02555.1; -; Genomic_DNA.
DR RefSeq; WP_000083719.1; NZ_AJRE01000465.1.
DR AlphaFoldDB; K0Z5U9; -.
DR Proteomes; UP000004724; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0047151; F:tRNA (uracil(54)-C5)-methyltransferase activity, 5,10-methylenetetrahydrofolate-dependent; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR HAMAP; MF_01037; TrmFO; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR002218; MnmG-rel.
DR InterPro; IPR020595; MnmG-rel_CS.
DR InterPro; IPR040131; MnmG_N.
DR InterPro; IPR004417; TrmFO.
DR NCBIfam; TIGR00137; gid_trmFO; 1.
DR PANTHER; PTHR11806; GLUCOSE INHIBITED DIVISION PROTEIN A; 1.
DR PANTHER; PTHR11806:SF2; METHYLENETETRAHYDROFOLATE--TRNA-(URACIL-5-)-METHYLTRANSFERASE TRMFO; 1.
DR Pfam; PF01134; GIDA; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS01281; GIDA_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EKA02555.1}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EKA02555.1};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 6..376
FT /note="MnmG N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01134"
FT NON_TER 417
FT /evidence="ECO:0000313|EMBL:EKA02555.1"
SQ SEQUENCE 417 AA; 45957 MW; 6EB124940FD1246C CRC64;
MSQSYINVIG AGLAGSEAAY QIAERGIPVK LYEMRGVKST PQHKTDNFAE LVCSNSLRGD
ALTNAVGLLK EEMRRLGSVI LESAEATRVP AGGALAVDRD GFSQMVTEKV ANHPLIEVVR
DEITELPTDV ITVVATGPLT SDTLAEKIHA LNDGDGFYFY DAAAPIIDVN TIDMSKVYLK
SRYDKGEAAY LNAPMTKQEF MDFHEALVNA EEAPLNSFEK EKYFEGCMPI EVMAKRGIKT
MLYGPMKPVG LEYPDDYTGP RDGEFKTPYA VVQLRQDNAA GSLYNIVGFQ THLKWGEQKR
VFQMIPGLEN AEFVRYGVMH RNSYMDSPNL LEQTYRSKKQ PNLFFAGQMT GVEGYVESAA
SGLVAGINAA RLFKGESEAI FPETTAIGSL AHYITHADSK HFQPMNVNFG IIKELEG
//
