ID   K0ZIA8_9ACTO            Unreviewed;       345 AA.
AC   K0ZIA8;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=CBS domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=HMPREF9240_00759 {ECO:0000313|EMBL:EJZ87410.1};
OS   Winkia neuii BV029A5.
OC   Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC   Winkia.
OX   NCBI_TaxID=888439 {ECO:0000313|EMBL:EJZ87410.1, ECO:0000313|Proteomes:UP000006075};
RN   [1] {ECO:0000313|EMBL:EJZ87410.1, ECO:0000313|Proteomes:UP000006075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BVS029A5 {ECO:0000313|EMBL:EJZ87410.1,
RC   ECO:0000313|Proteomes:UP000006075};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Saerens B., Vaneechoutte M.,
RA   Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA   Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA   Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA   Larimer J., McCowen C., Montmayeur A., Murphy C., Neiman D., Pearson M.,
RA   Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Actinomyces neuii subsp. anitratus BVS029A5.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJZ87410.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AGWP01000004; EJZ87410.1; -; Genomic_DNA.
DR   RefSeq; WP_004806074.1; NZ_JH815214.1.
DR   AlphaFoldDB; K0ZIA8; -.
DR   PATRIC; fig|888439.3.peg.764; -.
DR   eggNOG; COG1253; Bacteria.
DR   HOGENOM; CLU_015237_4_0_11; -.
DR   OrthoDB; 110231at2; -.
DR   Proteomes; UP000006075; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR002550; CNNM.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   PANTHER; PTHR43099:SF4; INTEGRAL MEMBRANE PROTEIN-RELATED; 1.
DR   PANTHER; PTHR43099; UPF0053 PROTEIN YRKA; 1.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF01595; CNNM; 1.
DR   SMART; SM00116; CBS; 2.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   PROSITE; PS51846; CNNM; 1.
PE   4: Predicted;
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000006075};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU01193};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW   ProRule:PRU01193}.
FT   TRANSMEM        6..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        56..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        98..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..202
FT                   /note="CNNM transmembrane"
FT                   /evidence="ECO:0000259|PROSITE:PS51846"
FT   DOMAIN          220..279
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   DOMAIN          285..341
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
SQ   SEQUENCE   345 AA;  37184 MW;  24D5F510474CCE29 CRC64;
     MGIGTGLIIA IALLAVNAFF VGAEFAVTSS RKSQIDPLVE EGRAGAKAAQ WALEHVSLML
     AVCQLGVTLA STALGAVAEP ALARAVRPLL LRFGLPAASS HLVAVIIALL VVLYLHVVVG
     EMIPKNLSVS APAKMVLVLA PPLVRLGRLV RPIVEGMDHF ANWFITKLGV EPKHEVAATF
     TAEEVATIVE LSEAEGKLTD DLGLLSGTLE FSEELVEAVM VGPEKLVTLP VQVTPAEFEK
     VVSQTGFSRF PLVDGTGEYV GYLHLKDVLQ ADSKEQRDKP VPSWWIRQLP KASPQDEVED
     ALRVMQMTGV HLAKVEREGS IVGVIFLEDI LEELVGEVRD VMQRQ
//