ID K0ZUQ1_9STRE Unreviewed; 1357 AA.
AC K0ZUQ1;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=Cell wall surface anchor family protein {ECO:0000313|EMBL:EKA10625.1};
GN ORFNames=GMD4S_06872 {ECO:0000313|EMBL:EKA10625.1};
OS Streptococcus sp. GMD4S.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1169673 {ECO:0000313|EMBL:EKA10625.1, ECO:0000313|Proteomes:UP000004724};
RN [1] {ECO:0000313|EMBL:EKA10625.1, ECO:0000313|Proteomes:UP000004724}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GMD4S {ECO:0000313|EMBL:EKA10625.1,
RC ECO:0000313|Proteomes:UP000004724};
RX PubMed=23493677; DOI=10.1101/gr.142208.112;
RA Fitzsimons M.S., Novotny M., Lo C.C., Dichosa A.E., Yee-Greenbaum J.L.,
RA Snook J.P., Gu W., Chertkov O., Davenport K.W., McMurry K., Reitenga K.G.,
RA Daughton A.R., He J., Johnson S.L., Gleasner C.D., Wills P.L.,
RA Parson-Quintana B., Chain P.S., Detter J.C., Lasken R.S., Han C.S.;
RT "Nearly finished genomes produced using gel microdroplet culturing reveal
RT substantial intraspecies genomic diversity within the human microbiome.";
RL Genome Res. 23:878-888(2013).
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC {ECO:0000256|ARBA:ARBA00004168}; Peptidoglycan-anchor
CC {ECO:0000256|ARBA:ARBA00004168}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKA10625.1}.
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DR EMBL; AJRE01000087; EKA10625.1; -; Genomic_DNA.
DR RefSeq; WP_000045544.1; NZ_AJRE01000087.1.
DR PATRIC; fig|1169673.3.peg.1312; -.
DR Proteomes; UP000004724; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR Gene3D; 2.60.40.1280; -; 1.
DR Gene3D; 2.60.40.3050; -; 7.
DR Gene3D; 2.60.40.740; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR008966; Adhesion_dom_sf.
DR InterPro; IPR011252; Fibrogen-bd_dom1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR019931; LPXTG_anchor.
DR InterPro; IPR041033; Prealbumin-like.
DR InterPro; IPR022464; Strep_pil_isopept_link.
DR InterPro; IPR038174; Strep_pil_link_sf.
DR NCBIfam; TIGR01167; LPXTG_anchor; 1.
DR NCBIfam; TIGR03786; strep_pil_rpt; 6.
DR Pfam; PF12892; FctA; 7.
DR Pfam; PF00746; Gram_pos_anchor; 1.
DR Pfam; PF17802; SpaA; 1.
DR SUPFAM; SSF49401; Bacterial adhesins; 1.
DR PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
PE 4: Predicted;
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Peptidoglycan-anchor {ECO:0000256|ARBA:ARBA00023088};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1335..1353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1326..1357
FT /note="Gram-positive cocci surface proteins LPxTG"
FT /evidence="ECO:0000259|PROSITE:PS50847"
FT REGION 1257..1328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1261..1299
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1357 AA; 145378 MW; 964BD97C0C7895EC CRC64;
MSKSKALNML SKFSALAFAI LGLASVLIGI VKADNPVSKE LTQVITGIDL LDASDTKQNV
SSEGDFSLRT NLAYKLRVTF DLKQYNEHLN NGDYFTFDIP APMAVYEGSQ DLIDPTTKVT
IGEAEVTSNG TDQGGKAKIT LKNLDKYLEK TGGDKVKDVS GNFSVTFRFL KDQNKTRINF
NSSSLKQEVT HIYSSKTIDG PKVGTENYAK IGGRAALENW NSPKLAEIGS VSKGDAWSTW
RVRVNTEKQD LGQNIVLHDT IPNDDTSYTP AQYIPETLKV YKANITVGTS AVPDDAVLLT
EGQDYTVSWN ENYTSFDIIF KDGTTSYIVS YNTTTPNDGS KVGNRVALSL ADGTKLAQNT
SRPGALDMTA EATSLISGTI VASTAYQIKI HKTDAFTLAP VSGAVYTVTA ADDASETTEV
TTNEKGVALT KTYDQKWEGK TFKIKEKTAP AGYKLDEKEY TVKLGAAGST IHLKDEPVPA
VFNVTAKKVV EGRTDKLPKA DEFTFNLFTA ENLKDPVATA KSKADGTITF ENLQVKGAGT
YHYIIKEDTS TAVAGVAFDT EAKEVTVAAT FQSGVLTATV TSAEPTFTNT YKATPAKETI
TAKKVLNGKD LEADKYEFEL KEGDKVVATA KNAADGTVTF KEIELETAGE YTYTITEKAG
SEKGVTYDTA KHEVKVKVTD NGQGQLVATV TGNNPTFTNT YKAAKTSATI TAKKVLEGKA
LEADKYEFEL KEGDKVVATA KNAADGTVTF KEIEYNEAGD HTYTISEKAG SEAGVTYDTA
THEVTVNVTD NGQGQLEAAV AGNNPTFTNT YKAAPAKIAI EAKKVLNGKE LEIDEFEFEL
KEGDKVVATA KNAAGGLIRF SEISYSKAGV YNYTITEKVG NKLGVTYDKT EHPATVEVKD
NGSGQLVATV TSETPVFVND YKAEPAQATI KAKKVLKGKA LEADAYTFEL KEGSDLVATA
KNTASGEVVF NVTFSAAGDY AYTITEKAGD DKTITYDQTA YEVFVTVADD GKGQLVATVE
DADTERVFTN IYTAPAPTAT SATLEFTKEL TGRTLVDGEF QFELYKDGQK IDTKTNQGGK
VTFNTINYDA EGVHTYTVKE VNAGATGITY DTEKTAKVTV TKDAATNALK AAVEYPAGNV
FKNSFKAPAV EATIEATKKL EGKELAADAY TFELKEKGAV VATAKNTAEG KVAFVRSFEE
AGTYTYTLVE KVGTEEGIEY DKTEHTVTVT VVADDQGLLT ARVSYADGKE VVFTNKYTVP
TPTPEPNPNP APNNPGTTPD PAPTPDPTPN NPGTNPTPGT EPTGPGQKED PKPAPPATET
KGKAELPNTG EATSILSALG FVVLALSGLV FFVKRKA
//
