ID   K1KGB4_9BURK            Unreviewed;       302 AA.
AC   K1KGB4;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   RecName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=HMPREF9465_01766 {ECO:0000313|EMBL:EKB30719.1};
OS   Sutterella wadsworthensis 2_1_59BFAA.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Sutterellaceae; Sutterella.
OX   NCBI_TaxID=742823 {ECO:0000313|EMBL:EKB30719.1, ECO:0000313|Proteomes:UP000005835};
RN   [1] {ECO:0000313|EMBL:EKB30719.1, ECO:0000313|Proteomes:UP000005835}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2_1_59BFAA {ECO:0000313|EMBL:EKB30719.1,
RC   ECO:0000313|Proteomes:UP000005835};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Strauss J.,
RA   Allen-Vercoe E., Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M.,
RA   Haas B., Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M.,
RA   Chapman S.B., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA   Imamovic A., Larimer J., McCowen C., Montmayeur A., Murphy C., Neiman D.,
RA   Pearson M., Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S.,
RA   Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Sutterella wadsworthensis 2_1_59BFAA.";
RL   Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the HIBADH-related family.
CC       {ECO:0000256|ARBA:ARBA00009080}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKB30719.1}.
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DR   EMBL; ADMG01000037; EKB30719.1; -; Genomic_DNA.
DR   AlphaFoldDB; K1KGB4; -.
DR   STRING; 742823.HMPREF9465_01766; -.
DR   PATRIC; fig|742823.3.peg.1763; -.
DR   eggNOG; COG2084; Bacteria.
DR   HOGENOM; CLU_035117_1_0_4; -.
DR   Proteomes; UP000005835; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR029154; HIBADH-like_NADP-bd.
DR   InterPro; IPR015815; HIBADH-related.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR   PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR   Pfam; PF14833; NAD_binding_11; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PIRSF; PIRSF000103; HIBADH; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005835}.
FT   DOMAIN          14..174
FT                   /note="6-phosphogluconate dehydrogenase NADP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF03446"
FT   DOMAIN          177..295
FT                   /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT                   /evidence="ECO:0000259|Pfam:PF14833"
FT   ACT_SITE        183
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ   SEQUENCE   302 AA;  31603 MW;  CC93453A37CE316C CRC64;
     MKMDKTYACV PSLKVAFVGL GVMGFPMAGH LKLAGHDVCV YNRTTAKAEK WVETFGGRMA
     ATPAEAVRGA GIVFACVGND DDLRSVVLGE TGAFAGMEPG TVFVDHTTAS AAVARELEAE
     GAKRGIAFID APVSGGQAGA ENGCLTVLCG GGEAAFRSVE PVLDAYAGAV TYFGPSGSGQ
     LAKMVNQICI AGCVQGLSEA IAFGMNAGLD MPKVIEALSS GAASSWQMVN RGRTMVKGEF
     DFGFAVDWMR KDLGIVKDEA ARNGSEIPVT RMVDSFYEEV QKAGGARWDT SSLITRLNRT
     MK
//