ID K1MER8_9LACO Unreviewed; 246 AA.
AC K1MER8;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Segregation and condensation protein A {ECO:0000256|HAMAP-Rule:MF_01805};
GN Name=scpA {ECO:0000256|HAMAP-Rule:MF_01805};
GN ORFNames=HMPREF9249_01450 {ECO:0000313|EMBL:EKB67685.1};
OS Lactobacillus crispatus FB077-07.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=883092 {ECO:0000313|EMBL:EKB67685.1, ECO:0000313|Proteomes:UP000004722};
RN [1] {ECO:0000313|EMBL:EKB67685.1, ECO:0000313|Proteomes:UP000004722}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FB077-07 {ECO:0000313|EMBL:EKB67685.1,
RC ECO:0000313|Proteomes:UP000004722};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Saerens B., Vaneechoutte M.,
RA Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Larimer J., McCowen C., Montmayeur A., Murphy C., Neiman D., Pearson M.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Lactobacillus crispatus FB077-07.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Participates in chromosomal partition during cell division.
CC May act via the formation of a condensin-like complex containing Smc
CC and ScpB that pull DNA away from mid-cell into both cell halves.
CC {ECO:0000256|HAMAP-Rule:MF_01805}.
CC -!- SUBUNIT: Component of a cohesin-like complex composed of ScpA, ScpB and
CC the Smc homodimer, in which ScpA and ScpB bind to the head domain of
CC Smc. The presence of the three proteins is required for the association
CC of the complex with DNA. {ECO:0000256|HAMAP-Rule:MF_01805}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01805}.
CC Note=Associated with two foci at the outer edges of the nucleoid region
CC in young cells, and at four foci within both cell halves in older
CC cells. {ECO:0000256|HAMAP-Rule:MF_01805}.
CC -!- SIMILARITY: Belongs to the ScpA family. {ECO:0000256|HAMAP-
CC Rule:MF_01805}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKB67685.1}.
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DR EMBL; AGZG01000077; EKB67685.1; -; Genomic_DNA.
DR RefSeq; WP_005720168.1; NZ_JH932273.1.
DR AlphaFoldDB; K1MER8; -.
DR GeneID; 69823414; -.
DR PATRIC; fig|883092.3.peg.1440; -.
DR HOGENOM; CLU_038686_3_1_9; -.
DR OrthoDB; 9811016at2; -.
DR Proteomes; UP000004722; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR Gene3D; 6.10.250.2410; -; 1.
DR HAMAP; MF_01805; ScpA; 1.
DR InterPro; IPR003768; ScpA.
DR PANTHER; PTHR33969; SEGREGATION AND CONDENSATION PROTEIN A; 1.
DR PANTHER; PTHR33969:SF2; SEGREGATION AND CONDENSATION PROTEIN A; 1.
DR Pfam; PF02616; SMC_ScpA; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|HAMAP-Rule:MF_01805};
KW Cell division {ECO:0000256|HAMAP-Rule:MF_01805};
KW Chromosome partition {ECO:0000256|HAMAP-Rule:MF_01805};
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01805}.
SQ SEQUENCE 246 AA; 28196 MW; 0A02D15E20B0E30E CRC64;
MDKSNLTLEL PNFEGPLDLL LHLIQSQKID IYDIPIAQIT SQYLEYLRQM QSLNLQIAGE
YFVMSSTLLR IKSQYLLPQN DFVDDIQPDE DPRDELVQQL VQYSVFKKIS AYFKERNEEV
PITVAKEASV STTAKVQPLP KGQITAQELA TTFTMVLHRL KLQQPDTASI RVAETPINEM
MDFLHGQLKR KRQVSFFACA DKMQNISDVI GLFLATLELC KKQLIQITQA REFGDLNLER
IDTNGK
//
