ID K1PTH4_CRAGI Unreviewed; 1098 AA.
AC K1PTH4;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=RING-type E3 ubiquitin transferase RAD18 {ECO:0000256|ARBA:ARBA00031783};
GN ORFNames=CGI_10020174 {ECO:0000313|EMBL:EKC27547.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC27547.1};
RN [1] {ECO:0000313|EMBL:EKC27547.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC27547.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- SIMILARITY: Belongs to the RAD18 family.
CC {ECO:0000256|ARBA:ARBA00009506}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC {ECO:0000256|ARBA:ARBA00010290}.
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DR EMBL; JH817192; EKC27547.1; -; Genomic_DNA.
DR AlphaFoldDB; K1PTH4; -.
DR HOGENOM; CLU_283602_0_0_1; -.
DR InParanoid; K1PTH4; -.
DR OMA; DMEMENS; -.
DR UniPathway; UPA00143; -.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR CDD; cd04150; Arf1_5_like; 1.
DR CDD; cd16529; RING-HC_RAD18; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR045872; Arf1-5-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006642; Rad18_UBZ4.
DR InterPro; IPR003034; SAP_dom.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR11711; ADP RIBOSYLATION FACTOR-RELATED; 1.
DR PANTHER; PTHR11711:SF110; ADP-RIBOSYLATION FACTOR 4; 1.
DR Pfam; PF00025; Arf; 1.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR PRINTS; PR00328; SAR1GTPBP.
DR SMART; SM00177; ARF; 1.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00513; SAP; 1.
DR SMART; SM00178; SAR; 1.
DR SMART; SM00734; ZnF_Rad18; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51417; ARF; 1.
DR PROSITE; PS50800; SAP; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00022707};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Myristate {ECO:0000256|ARBA:ARBA00022707};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
SQ SEQUENCE 1098 AA; 124233 MW; 58F36512BA630F0A CRC64;
MGLTISSLFN RLFGKRAMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN
ISFTVWDVGG QDKIRPLWRH YFQNTHGLIF VVDSNDRERV EEARAELKKM LEEDELRDAI
LLVFANKQDL PNAMSASEIT EKLGLSALRG RKMLSPKTLK KLPKTVHSPK DWSYLEMKEI
DSLLRCPICY DFMHTAMILP ECSHTFCSFC IRQHLSHTNQ CPACNHGACE NNLRNNRLVD
DLIVQFKAIR SLLLEITQKH SNEKDSDLNQ SNETVLQESK TQKKLPNSKT ITSIPTTVKD
DVIDLISEDG EGKEEDESED WKLRENKENQ GISTPGKSLP DRDGGGELST PRNQRSSLQS
MFSPSPKQMV SCPVCGLSLR EGAMNDHLDL CLGGEEKKSA LRKPTPKRKP MAKLVYNLMS
ERDIKKKLKE VGLSTAGDKK TLVRRHHDFV MLYNSECDAL KPKSVQEIVK EVEKTENIRN
RSRTDHSRLL IEKNSSPATI EKAQKIYMKK HKSHFSDLIA ETKKRMREQR MKQKKSSDGK
DLGPESEAET SVTEASDTGT VGTQSESEGK GRRMSSRNRK RAGMGQCDEE EVLSGKQDII
EMSSQSETEG GTRRKSSRMK VKVIREEDME MENSDGDGSE LEVVSVQNET ECERRMSVRH
QGKNMSDQGK TGGSCVEYES ERKMKKSRNS KGVKKEVAEI DEDSDPVSQI ETDGKSRRRS
VRNKSKIESS KATENESTED TEQNNQRRTR NRNTSLSAMT KTTNEAKRQS GQERKQDRNM
GNEPKENRHQ NHTPKRSTQN KKSDPNSSRA KKAYTEIDTG DSSEEKVTEM EVESDFQEQD
EGSAGKNEPD LLDMVDKADI LSTLPGKNGH SKSKSNNNEG TFKRKKNLKR SQNIDIEEEM
LDKQCGIYEE DKEVELEPST RLKDGEVEMM KHECLMESLN GEKHISIKDQ SDKSVGIVAD
GSGHASLQTT PKLKSKTCDE KNEAGKSENL EKDDSLHIDE TPVKEYDVDI STLWPALSGA
VVVSTSRTRH LSSISTKSDK SNCSDLSAVF SPIKDLKNME GEDEKNKRLP VKREISGDFE
NRKRKRLSEP ASRKRRRR
//
