ID   K1Q1V8_CRAGI            Unreviewed;      1004 AA.
AC   K1Q1V8;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   SubName: Full=Caspase {ECO:0000313|EMBL:EKC25344.1};
GN   ORFNames=CGI_10022344 {ECO:0000313|EMBL:EKC25344.1};
OS   Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX   NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC25344.1};
RN   [1] {ECO:0000313|EMBL:EKC25344.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC25344.1};
RX   PubMed=22992520; DOI=10.1038/nature11413;
RA   Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA   Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA   Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA   Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA   Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA   Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA   Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA   Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA   Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA   Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA   Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT   "The oyster genome reveals stress adaptation and complexity of shell
RT   formation.";
RL   Nature 490:49-54(2012).
CC   -!- SIMILARITY: Belongs to the peptidase C14A family.
CC       {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR   EMBL; JH815992; EKC25344.1; -; Genomic_DNA.
DR   AlphaFoldDB; K1Q1V8; -.
DR   HOGENOM; CLU_299028_0_0_1; -.
DR   InParanoid; K1Q1V8; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1460; -; 1.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   InterPro; IPR011600; Pept_C14_caspase.
DR   InterPro; IPR002138; Pept_C14_p10.
DR   InterPro; IPR001309; Pept_C14_p20.
DR   InterPro; IPR015917; Pept_C14A.
DR   PANTHER; PTHR47901; CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18; 1.
DR   PANTHER; PTHR47901:SF8; CASPASE-3; 1.
DR   Pfam; PF00656; Peptidase_C14; 1.
DR   PRINTS; PR00376; IL1BCENZYME.
DR   SMART; SM00115; CASc; 1.
DR   SUPFAM; SSF52129; Caspase-like; 1.
DR   PROSITE; PS50207; CASPASE_P10; 1.
DR   PROSITE; PS50208; CASPASE_P20; 1.
PE   3: Inferred from homology;
FT   DOMAIN          747..871
FT                   /note="Caspase family p20"
FT                   /evidence="ECO:0000259|PROSITE:PS50208"
FT   DOMAIN          900..994
FT                   /note="Caspase family p10"
FT                   /evidence="ECO:0000259|PROSITE:PS50207"
SQ   SEQUENCE   1004 AA;  113439 MW;  890D24C1F99B4871 CRC64;
     MEIFKLAQSY KIDWGLVLDG KVYEVLSAHA QSLGCELDLF MLPLFVSAAN FMGPKTKIQI
     TQSWIERPSL MGIVAARRGE RKTTVLNFIK GCSRRVQTET RVTKEEETRS TETGLKDAMN
     VDGVTETCNV NGSRLFVIDD LDEVMKQVTK APDFWNSYTL QKSVLLPYSD ASYSENINVA
     ATVQGAQITE IINWPDPGRL LDRVLVLCAR DSEEMTFSLK QCTSLHIIFQ RVHELYNNND
     ITYTFSDDAL QELERMAGVV NSIKKECHND ELKRGCANHV MSQTARLSAV SHALTHAVSD
     SRSDYVISKT TVQGMFVICL YMLRQKCLLL HGSDSAGYSQ LFHSILSSEV ELLKPTEVRN
     AFNSQENGDD VIEITLDGNN EPVARIIPKR EDKEENPSME ASSSSDVTIW QMETRDRDEN
     QMERSLSSMY YPGVQTSQQQ IIEYQKQHGM MTTSPSRETV NLQHYEPDQL CVSKNESPKQ
     DNMTSVLRPR GKFRPPPPPL KPRPHQLHMN RRFIPAPKRL NDRTQHKTCV FTCSDNIFVQ
     ICFAKIRKCL LTKGLFITSS YACQYRLFPP VPLVQRTSSP RTTHPSWAAV KFFERLETLG
     FGEVTVFRSQ SVKFKKKPLE EMSERARNIL KQVGIAEDEY ISALTTDDDV SLTSLPEYNY
     LFTVNQNGNM ETEDAEEQVQ GIPHSDDRML CSQPGDNDVG SVEPRVENTA QSRQQSSTGA
     PPISPQTSNE PTVGRDTDSS YSFTHSKRGY AVLIMNHEFA NEDENLPGVK HDIDSMSRLF
     TSMDFEVRQL INLTGDQLVS DLRGDTHGGE DPGFYANSPQ EPGYTKTEHY VLNNEGALWT
     RHIMDMFNDQ HCKALRGKPR LFFVQACRGN DVDKGVYLNE NTENFESNKD QSEDISLNQD
     VFQIPCYNDF LVMFSSTSGK YAWSEDLEGG WLLSAIDQVF SSGSAGDDLL SLLTQVCGEV
     ASREAFIPNN ERAHCSKSTA CVYHKLSKDI YFPSSKTKYS DVDC
//