ID   K1QCR8_CRAGI            Unreviewed;      1543 AA.
AC   K1QCR8;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=Hemicentin-1 {ECO:0000313|EMBL:EKC19316.1};
GN   ORFNames=CGI_10008940 {ECO:0000313|EMBL:EKC19316.1};
OS   Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX   NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC19316.1};
RN   [1] {ECO:0000313|EMBL:EKC19316.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC19316.1};
RX   PubMed=22992520; DOI=10.1038/nature11413;
RA   Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA   Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA   Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA   Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA   Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA   Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA   Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA   Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA   Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA   Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA   Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT   "The oyster genome reveals stress adaptation and complexity of shell
RT   formation.";
RL   Nature 490:49-54(2012).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JH823253; EKC19316.1; -; Genomic_DNA.
DR   HOGENOM; CLU_246735_0_0_1; -.
DR   InParanoid; K1QCR8; -.
DR   CDD; cd00037; CLECT; 1.
DR   CDD; cd00112; LDLa; 1.
DR   Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR   Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   PANTHER; PTHR14905:SF7; HET-C DOMAIN PROTEIN HETC (AFU_ORTHOLOGUE AFUA_2G15840); 1.
DR   PANTHER; PTHR14905; NG37; 1.
DR   Pfam; PF00057; Ldl_recept_a; 1.
DR   Pfam; PF00059; Lectin_C; 1.
DR   SMART; SM00034; CLECT; 1.
DR   SMART; SM00192; LDLa; 1.
DR   SUPFAM; SSF56436; C-type lectin-like; 1.
DR   SUPFAM; SSF57424; LDL receptor-like module; 1.
DR   SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR   PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR   PROSITE; PS50068; LDLRA_2; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID        184..202
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        196..211
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ   SEQUENCE   1543 AA;  168406 MW;  466BAB0B2FDFB22E CRC64;
     MVKQYMQNQS GQKQHTIGFR WCLGHNDGKM GDIDFKCPSG SKFYQGYCFR KETVPMTWKH
     AKTACLRSGM YLAWIEDGIE NEYVATHVMF DVNQYWIGLS NTSSTAGQNE VSWSQYRMSE
     DKTIPVYKGL WKNLQPADFI EENKCVSTRK DKYDNHWTVT NCRKKLPFVC KLMGAPKPHD
     IIFCGNGGYI HKNWKCDGQN DCGDMSDEID CSSSCSELRM LEKGKTGTIT ITSVDNNAFC
     TWTIQAPVGA RIKITIKDTS IYNTTDGKEM KKWLHNMTAH GGGDCPEMAL TGIVNALKIA
     NPGSCVFFFT DADAKDPEKQ NEVINLINAK HFKLVYFLRG DCGGGSRRRR SEFTVQNPTC
     ILNDNSRRAG RARRSSAGFD LFSKIASATG GQIVHTSSSS LGGLLGSFVK NNMGASKLGV
     TSFEMSTPTH SISVDSDLSI LTVTIEGLSS AIYVSLDRPD GSTQMFSGTA SIDEIGSTTV
     ISVQNPPAGV WNLQKSQTGT WRVKVGGSGN IDFTYKFMED VHGIKYPITG TSPITGSKLL
     ISISVTGLSP SARVTNIILK KPNGVILTKL PVSDTSSGSN RVLYAYFDVT PEEFFVSING
     SIGTNIFTRE KSDIIRPVTG EITFTSKPEN LVLGENSVID VAVKNTGSTS QTYQLTATSV
     PSGFPTQRSY SVTVGPRSNK EISLTLTPTN ISVATLSVKL TLGGQTLQTI SRTLMVVDVP
     PPKFNEVNRT SSCRQEMLNY YNCKKQNWTL VLDVAFRASL SQLYVTPTTV QLKYARNSPS
     VYVATLSGTC CTYKSQLTAI DARGNMKTKT IDFLGGNVFN TTVENFDILT KPIPVKTDKK
     HESLVHYIKV LTLAGAGTMV LALVVAIMLL FWLDGDCRMV HFLQTIEDII NKVAQTQRYH
     HGDSARTMSC NQIEAGHLLL QSLRDEIINQ SQAANPNWDA VRDLTGQYLF TLQEFYSNTN
     WVEIFGNQIC QDLDECYLDP RKKQGVNKET SRPENTLDHL QQQAMEAATR ASVEFLIGEG
     TGLLHIIGID KFKELLGMTH KKLCYNCLAQ GLSVILIMDG AGSVSRETRA TTRSNIDANQ
     RESSERMRRG SGGLDFFDKI ASATGGLIVH TTSTSLGTIL GSFVANNMGV AGLEVDSFTM
     SSGTEHTWSV DEDLSLLTVR IEGVSSTSML TLDRPDGSTQ AFSGSASVDV IGSTTVLSIQ
     KPPAGKWTLH KMESGTWKVK VGGSGNIDFT YKFMEDVHGI KYPITGTSPI TGTTVLLSVT
     VTGLPVAARV LHIILKTLDG AILKVLPVKD NYSDASRVLY AEYNVTSEEF LVSINGILHS
     QTFTREKSEA VTPVTGSVEF SSKPEKLVLG KTSVIEVNVT NTGSARRVFQ VTKTSTPAGF
     VTGSSLPVSV AAHAFKIVNI PVTAKSLTLA GTCCVYRSTV TAIDIRGNMK TWPVDFSGGQ
     TFNTTVENFD RLVKSEKISS VSNKSFLYGV IGGGIGGLVV VAAIVAVLVY FNRARGKAPE
     DDGVDSLSAS CFEASFKHVH ETFLRYGLSV FLRYDLGKKL GTS
//